Jay P. McLaughlin - Publications, H-index & Citations

Jay P. McLaughlin

State University System of Florida

43H指数

167论文数

6.0K被引数

收录论文 78

发表时间

Human α1-Antitrypsin Inhibits Nociceptor Excitability and Relieves Inflammatory and Neuropathic Pain 人α1-抗胰蛋白酶抑制伤害性感受器兴奋性并缓解炎症性和神经病理性疼痛

Biomolecules

IF4.8

2026-08-14

OAAI

Alaina L. Waters; Santiago Loya-López; Erick J. Rodriguez-Palma; Shainnel O. Eans; Ryosuke Shinouchi; Jordan Stokes; Jay P. McLaughlin; Sihong Song; Rajesh Khanna

Epigenetic LOCK chromatin links H3K9 modifications to ATM–γH2AX signaling in HIV-Tat and opioid neuroinflammation 表观遗传锁定染色质将H3K9修饰与ATM–γH2AX信号通路在HIV-Tat和阿片类药物神经炎症中联系起来

Cell Death & Disease

IF9.6

2026-08-05

OAAI

Karthick Chennakesavan; Malar Samikkannu; Haylee R. Hammond; Shainnel O. Eans; Marc J. Kaufman; Jay P. McLaughlin; Thangavel Samikkannu

Efficacy Modulation and Structural Insights of Mu Opioid-Sparing Agents μ阿片受体激动剂替代药物的功效调节与结构解析

Journal of Pharmacology and Experimental Therapeutics

IF3.8

2026-05-01

PREAI

Paul, Barnali; Huang, Peng; Ramos-gonzalez, Nokomis; Wang, Junzheng; Wells, Emily; Hammond, Haylee r.; Sortman, Bo w; Tanguturi, Parthasaradhireddy; Polley, Arghya; Appourchaux, Kevin; Seekins, Caleb a; Warren, Brandon l; Streicher, John m; Kobilka, Brian k; Chen, Chunlai; Mclaughlin, Jay p.; O'brien, Evan; Majumdar, Susruta

Optimization of the Macrocyclic Tetrapeptide [D-Trp]CJ-15,208 to Prevent Stress-Induced Relapse of Cocaine-Seeking Behavior [优化大环四肽[D-Trp]CJ-15,208以预防压力诱导的可卡因寻求行为的复发]

Molecules 2025, Vol. 30, Page 3993

IF4.6

2025-10-05

OAAI

Jane V. Aldrich; Dmitry Y. Yakovlev; Jeremy S. Coleman; Sanjeewa N. Senadheera; Heather M. Stacy; Shainnel O. Eans; Brian I. Knapp; Jean M. Bidlack; Jay P. McLaughlin

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic 吗啡烷衍生物双效μ-κ阿片受体激动剂镇痛药的合成与药理学

ACS Chemical Neuroscience

IF3.9

2025-06-26

PREAI

Balazs R. Varga; Rajendra Uprety; Barnali Paul; Alexis Knoll; Nokomis Ramos-Gonzalez; Kevin Appourchaux; Tori Taylor; Bengisu Turgutalp; Ryosuke Shinouchi; Shainnel O. Eans; Ashai K. Williams; Steven G. Vasquez-Grinnell; Saheem Zaidi; Antonina L. Nazarova; Andras Varadi; Valerie Le Rouzic; Taylor G. Brown; Shani Martinez; Michael Ansonoff; Rebecca Notis Dardashti; Amanda Hunkele; Joan Subrath; Matthew Welch; Jin Xu; Grace C. Rossi; John Pintar; Gavril W. Pasternak; Vsevolod Katritch; Jay P. McLaughlin; Ying Xian Pan; Susruta Majumdar

Structure-guided design of partial agonists at an opioid receptor 阿片受体部分激动剂的构效关系设计

NATURE COMMUNICATIONS

IF15.7

2025-03-13

OAAI

Varga, Balazs R.; Bernhard, Sarah M.; El Daibani, Amal; Zaidi, Saheem A.; Lam, Jordy H.; Aguilar, Jhoan; Appourchaux, Kevin; Nazarova, Antonina L.; Kouvelis, Alexa; Shinouchi, Ryosuke; Hammond, Haylee R.; Eans, Shainnel O.; Weinreb, Violetta; Margolis, Elyssa B.; Fay, Jonathan F.; Huang, Xi-Ping; Pradhan, Amynah; Katritch, Vsevolod; Mclaughlin, Jay P.; Majumdar, Susruta; Che, Tao

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2025-02-06

PREAI

Hammond, Haylee R.; Chaudhari, Prakash; Bunnell, Ashley; Nefzi, Khadija; Chen, Chongguang; Zhao, Pingwei; Eans, Shainnel O.; Masood, Sabrina R.; Dooley, Colette T.; Liu-Chen, Lee-Yuan; Mclaughlin, Jay P.; Nefzi, Adel

Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2024-12-01

PREAI

Zhu, Jun; Cirincione, Abagail B.; Strauss, Matthew J.; Davis, Sarah E.; Eans, Shainnel O.; Tribbitt, Danielle K.; Alshakhshir, Nadine; McLaughlin, Jay P.

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

ACS CENTRAL SCIENCE

IF10.4

2024-07-17

OAAI

Ople, Rohini S.; Ramos-Gonzalez, Nokomis; Li, Qiongyu; Sobecks, Briana L.; Aydin, Deniz; Powers, Alexander S.; Faouzi, Abdelfattah; Polacco, Benjamin J.; Bernhard, Sarah M.; Appourchaux, Kevin; Sribhashyam, Sashrik; Eans, Shainnel O.; Tsai, Bowen A.; Dror, Ron O.; Varga, Balazs R.; Wang, Haoqing; Huttenhain, Ruth; McLaughlin, Jay P.; Majumdar, Susruta

Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide

MOLECULES

IF4.6

2023-11-11

OAAI

Li, Yangmei; Eans, Shainnel O.; Ganno-Sherwood, Michelle; Eliasof, Abbe; Houghten, Richard A.; McLaughlin, Jay P.

Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference

PHARMACEUTICALS

IF4.8

2023-08-29

OAAI

Scherrer, Kristen H.; Eans, Shainnel O.; Medina, Jessica M.; Senadheera, Sanjeewa N.; Khaliq, Tanvir; Murray, Thomas F.; Mclaughlin, Jay P.; Aldrich, Jane V.

Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA

brain behavior and immunity

IF0

2023-08-01

OAAI

Ramasamy, Tamizhselvi; Doke, Mayur; McLaughlin, Jay P.; Samikkannu, Thangavel

Structure based approaches on fentanyl template to design novel mu opioid modulators 基于结构的芬太尼模板设计新型 μ 阿片调节剂

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-06-01

OAAI

Ople, Rohini; Wang, Haoqing; Li, Qiongyu; Polacco, Ben; Bernhard, Sarah; Appourchaux, Kevin; Sribhashyam, Sashrik; Eans, Shainnel; Huttenhain, Ruth; McLaughlin, Jay; Kobilka, Brian; Majumdar, Susruta

Structure, Function, and Pharmacology of Delta Opioid Receptor Bitopics

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-06-01

OAAI

Bernhard, Sarah; Varga, Balazs R.; El Daibani, Amal; Lam, Jordy H.; Zaidi, Saheem; Appourchaux, Kevin; Eans, Shainnel; Katritch, Vsevolod; McLaughlin, Jay; Majumdar, Susruta; Che, Tao

Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration

MOLECULES

IF4.6

2023-02-15

OAAI

Rayala, Ramanjaneyulu; Tiller, Annika; Majumder, Shahayra A. A.; Stacy, Heather M. M.; Eans, Shainnel O. O.; Nedovic, Aleksandra; McLaughlin, Jay P. P.; Cudic, Predrag

Sleep Disorder and Cocaine Abuse Impact Purine and Pyrimidine Nucleotide Metabolic Signatures

METABOLITES

IF3.7

2022-09-15

OAAI

Doke, Mayur; McLaughlin, Jay P.; Baniasadi, Hamid; Samikkannu, Thangavel

HIV-1 Tat and cocaine impact astrocytic energy reservoirs and epigenetic regulation by influencing the LINC01133-hsa-miR-4726-5p-NDUFA9 axis

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2022-09-01

OAAI

Doke, Mayur; McLaughlin, Jay P.; Cai, James J.; Pendyala, Gurudutt; Kashanchi, Fatah; Khan, Mansoor A.; Samikkannu, Thangavel

Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection

MOLECULAR BRAIN

IF2.9

2022-08-08

OAAI

Sundar, Vaishnavi; McLaughlin, Jay P.; Samikkannu, Thangavel

Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain

MOLECULES

IF4.6

2022-06-04

OAAI

Wilson, Lisa L.; Alleyne, Amy R.; Eans, Shainnel O.; Cirino, Thomas J.; Stacy, Heather M.; Mottinelli, Marco; Intagliata, Sebastiano; McCurdy, Christopher R.; McLaughlin, Jay P.

An analog of [D-Trp]CJ-15,208 exhibits kappa opioid receptor antagonism following oral administration and prevents stress-induced reinstatement of extinguished morphine conditioned place preference [D-trp] CJ-15的类似物，208在口服给药后表现出 κ 阿片受体拮抗作用，并防止压力诱导的消失的吗啡条件性位置偏爱的恢复

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2022-06-01

OAAI

Brice-Tutt, Ariana C.; Eans, Shainnel O.; Yakovlev, Dmitry; V. Aldrich, Jane; McLaughlin, Jay P.

研究方向