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C

Cyndi Qixin He

merck & co., inc.

H指数:17

被引数:648

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A unified platform for nucleoside analog synthesis

核苷类似物合成的一体化平台

IF45.8

2026-03-050

PRE

Asymmetric Synthesis of KRAS G12C Inhibitor MK-1084 via a Crystallization-Induced Diastereomer Transformation (CIDT)

通过结晶诱导的非对映体转化 (CIDT) 不对称合成KRAS G12C抑制剂MK-1084

ORGANIC LETTERS

IF5

2026-01-010

PRE

C-H Aminoalkylation of 5-Membered Heterocycles: Influence of Descriptors, Data Set Size, and Data Quality on the Predictiveness of Machine Learning Models and Expansion of the Substrate Space Beyond 1,3-Azoles

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2025-02-110

PRE

Impurity Control Strategy of TMS-Triol in the Manufacture Development of Islatravir

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-12-230

PRE

Persistent organonickel complexes as general platforms for Csp2-Csp3 coupling reactions

NATURE CHEMISTRY

IF20.2

2024-04-292

PRE

Broad Survey of Selectivity in the Heterogeneous Hydrogenation of Heterocycles

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-01-198

PRE

Accessing three-dimensional molecular diversity through benzylic C-H cross-coupling

NATURE SYNTHESIS

IF20

2023-06-0112

OA

Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

GREEN CHEMISTRY

IF9.2

2023-01-0114

PRE

Accessing Diverse Azole Carboxylic Acid Building Blocks via Mild C-H Carboxylation: Parallel, One-Pot Amide Couplings and Machine-Learning-Guided Substrate Scope Design

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-12-0912

PRE

Analysis of laboratory-evolved flavin-dependent halogenases affords a computational model for predicting halogenase site selectivity

IF11.6

2022-10-0110

OAAI

Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-08-162

PRE

Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2022-02-145

PRE

Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-07-286

PREAI

Lewis acid mediated, mild C-H aminoalkylation of azoles via three component coupling

CHEMICAL SCIENCE

IF7.4

2021-01-012

OAAI

Development of a Commercial Manufacturing Route to 2-Fluoroadenine, The Key Unnatural Nucleobase of Islatravir

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-07-3117

PREAI

Development of a Zinc-Mediated Approach to a 2,3-cis-Pyrrolidine Arginase Inhibitor

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-06-096

PREAI

Thermodynamic consequences of Tyr to Trp mutations in the cation-π-mediated binding of trimethyllysine by the HP1 chromodomain

CHEMICAL SCIENCE

IF7.4

2020-01-0115

OAAI

Catalytic Effects of Ammonium and Sulfonium Salts and External Electric Fields on Aza-Diels-Alder Reactions

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2019-12-3123

PREAI

Mechanism and Regioselectivity of an Unsymmetrical Hexadehydro-Diels-Alder (HDDA) Reaction

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2019-01-2317

PREAI

Organocatalytic [6+4] Cycloadditions via Zwitterionic Intermediates: Chemo-, Regio-, and Stereoselectivities

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2018-09-2539

PREAI