Christina L. L. Chai

National University of Singapore

H指数:45

被引数:6,868

个人简介

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Evaluating Molecular Docking Programs for RNA-Targeted Ligand Screening: Influence of Binding Modes and Ligand Types

评估RNA靶向配体筛选的分子对接程序：结合模式和配体类型的影响

Journal of Chemical Information and Modeling

IF5.3

2026-05-120

PRE

Letting Go of Pains and Other Dogmas

放下痛苦与其他教条

CHEMMEDCHEM

IF3.4

2025-09-110

OAAI

Calcaratarin D, a labdane diterpenoid, attenuates bleomycin-induced pulmonary fibrosis by blocking Wnt/(3-catenin signaling pathway

Calcaratarin D，一种labdane型二萜类化合物，通过阻断Wnt/(3-catenin信号通路来减轻博来霉素诱导的肺纤维化。

PHARMACOLOGICAL RESEARCH

IF10.5

2025-06-010

OAAI

Mutagenesis-Guided Target Identification Reveals the Protein-Binding Domain of Nsp14 in Coronaviruses as the Target of a Labdane-Oxindole Compound

基于诱变指导的靶点鉴定揭示了一种类二萜-恶唑烷二酮化合物在冠状病毒中Nsp14的蛋白质结合结构域为其作用靶点

ACS INFECTIOUS DISEASES

IF3.8

2025-04-100

PRE

Identification of Small-Molecule Inhibitors for Enterovirus A71 IRES by Structure-Based Virtual Screening

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2025-03-010

PRE

Syntheses of Minutuminolate and Related Coumarin Natural Products and Evaluation of Their TNF-α Inhibitory Activities

ACS OMEGA

IF4.3

2023-10-231

OAAI

Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy

PHARMACOLOGICAL RESEARCH

IF10.5

2023-08-014

OAAI

Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2022-12-202

PRE

Small-molecule enhancers of CRISPR-induced homology-directed repair in gene therapy: A medicinal chemist's perspective

DRUG DISCOVERY TODAY

IF7.5

2022-09-018

PRE

COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?

新型冠状病毒肺炎和小分子疗法的前景: 有教训吗？

PHARMACOLOGICAL RESEARCH

IF10.5

2022-05-0125

OAAI

Promoting GAINs (Give Attention to Limitations in Assays) over PAINs Alerts: no PAINS, more GAINs

CHEMMEDCHEM

IF3.4

2022-02-117

PRE

Discovery and development of labdane-oxindole hybrids as small-molecule inhibitors against chikungunya virus infection

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-02-015

PRE

Evaluation of 2-Bromoisobutyryl Catechol Derivatives for Atom Transfer Radical Polymerization-Functionalized Polydopamine Coatings

LANGMUIR

IF3.9

2021-07-168

PRE

From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action (vol 204, 112481, 2020)

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-01-010

PREAI

Polypharmacology of andrographolide: beyond one molecule one target

NATURAL PRODUCT REPORTS

IF10.6

2021-01-0124

PREAI

Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2H-Chromenes

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2020-11-3027

PREAI

From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-10-0124

PREAI

Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2020-09-0119

OAAI

A fluorescence-displacement assay using molecularly imprinted polymers for the visual, rapid, and sensitive detection of the algal metabolites, geosmin and 2-methylisoborneol

ANALYTICA CHIMICA ACTA

IF6

2019-08-0119

PREAI

The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2019-07-0121

PREAI

Christina L. L. Chai

个人简介

教育背景

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