Colin J. Henderson - Publications, H-index & Citations

Colin J. Henderson

University of Dundee

51H指数

307论文数

1.1W被引数

收录论文 92

发表时间

Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals

Archives of Toxicology

IF6.9

2026-06-27

OAAI

C. J. Henderson; A. W. McLaren; A. K. MacLeod; D. Lin; A. R. Cameron; L. R. Chatham; J. Moggs; F. Inesta‑Vaquera; John P. Thomson; Richard R. Meehan; P. Chakravarty; M. Schwarz; C. Roland Wolf

Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332 致编辑函：关于综述文章的评论——山田T、科恩SM、莱克BG. 激活性常驻雄烷受体（CAR）和过氧化物增殖激活受体α（PPARα）诱导啮齿动物肝脏肿瘤形成的机制与人类癌症风险无关：一项更新的批判性评估. 批评性毒理学评论. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332

Critical Reviews in Toxicology

IF4.1

2026-01-01

PREAI

Wolf, C. Roland; Henderson, Colin J.; Schwarz, Michael; Inesta-Vaquera, Francesco; Meehan, Richard R.

APPLICATION OF A MOUSE MODEL HUMANIZED FOR CYTOCHROME P450-MEDIATED DRUG METABOLISM TO PREDICT DRUG-DRUG INTERACTIONS BETWEEN PEPTIDE AND SMALL MOLECULE DRUGS 构建用于细胞色素P450介导的药物代谢的人源化小鼠模型，以预测肽类药物与小分子药物之间的药物相互作用

Drug Metabolism and Disposition

IF4

2025-08-26

PREAI

Yury Kapelyukh; Charlotte Gabel-Jensen; Alastaire Kenneth MacLeod; Kevin-Sebastien Daniel Coquelin; Laste Stojanovski; Laura Frame; Amy Tavendale; Colin J. Henderson; Kevin D. Read; Charles Roland Wolf; Carolina Säll

The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals 强效的人类CAR激动剂CITCO是人体化组成型雄烷受体小鼠中的非遗传毒性肝肿瘤促进剂，但不是野生型动物中的。

ARCHIVES OF TOXICOLOGY

IF6.9

2025-03-05

OAAI

Henderson, C. J.; Mclaren, A. W.; Macleod, A. K.; Lin, D.; Cameron, A. R.; Chatham, L. R.; Moggs, J.; Inesta-Vaquera, F.; Thomson, John P.; Meehan, Richard R.; Chakravarty, P.; Schwarz, M.; Wolf, C. Roland

Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone 使用广泛的人源化小鼠模型预测接受地塞米松的患者的药物-药物相互作用的风险

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-02-01

PREAI

George, Jacob; Chalmers, James D.; Coquelin, Kevin-Sebastien; Frame, Laura; Henderson, Colin J.; Kapelyukh, Yury; Lang, Chim C.; Read, Kevin D.; Stanley, Lesley A.; Wolf, C. Roland

Cysteine post-translational modifications regulate protein interactions of caveolin-3

FASEB JOURNAL

IF4.2

2024-03-11

OAAI

Ashford, Fiona; Kuo, Chien-Wen; Dunning, Emma; Brown, Elaine; Calagan, Sarah; Jayasinghe, Izzy; Henderson, Colin; Fuller, William; Wypijewski, Krzysztof

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism 使用人性化的药物代谢模型加速传染病药物的发现和开发

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-02-05

OAAI

Macleod, Kenneth; Coquelin, Kevin-Sebastien; Huertas, Leticia; Simeons, Frederick R. C.; Riley, Jennifer; Casado, Patricia; Guijarro, Laura; Casanueva, Ruth; Frame, Laura; Pinto, Erika G.; Ferguson, Liam; Duncan, Christina; Mutter, Nicole; Shishikura, Yoko; Henderson, Colin J.; Cebrian, David; Wolf, C. Roland; Read, Kevin D.

Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers

SCIENCE OF THE TOTAL ENVIRONMENT

IF8

2023-08-01

OAAI

Inesta-Vaquera, Francisco; Miyashita, Lisa; Grigg, Jonathan; Henderson, Colin J.; Wolf, C. Roland

Identification of novel roles of the cytochrome P450 system in early embryogenesis: Effects on vasculogenesis and retinoic acid homeostasis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

160

OAAI

Otto, DME; Henderson, CJ; Carrie, D; Davey, M; Gundersen, TE; Blomhoff, R; Adams, RH; Tickle, C; Wolf, CR

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Schmidt, Katy; Hughes, Catherine; Chudek, J. A.; Goodyear, Simon R.; Aspden, Richard M.; Talbot, Richard; Gundersen, Thomas E.; Blomhoff, Rune; Henderson, Colin; Wolf, C. Roland; Tickle, Cheryll

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

BRITISH JOURNAL OF CANCER

IF6.8

2021-10-07

OAAI

Hamis, Sara J.; Kapelyukh, Yury; McLaren, Aileen; Henderson, Colin J.; Wolf, C. Roland; Chaplain, Mark A. J.

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer Nrf2激活不影响结肠直肠癌小鼠模型的腺瘤发展

COMMUNICATIONS BIOLOGY

IF5.1

2021-09-15

OAAI

Knatko, Elena, V; Castro, Cecilia; Higgins, Maureen; Zhang, Ying; Honda, Tadashi; Henderson, Colin J.; Wolf, C. Roland; Griffin, Julian L.; Dinkova-Kostova, Albena T.

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity 体内氧化应激报告基因Hmox1作为砷毒性机制生物标志物的应用

ENVIRONMENTAL POLLUTION

IF7.3

2021-02-01

OAAI

Inesta-Vaquera, Francisco; Navasumrit, Panida; Henderson, Colin J.; Frangova, Tanya G.; Honda, Tadashi; Dinkova-Kostova, Albena T.; Ruchirawat, Mathuros; Wolf, C. Roland

Effects of 2-MCPD on oxidative stress in different organs of male mice

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2020-08-01

OAAI

Schultrich, Katharina; Henderson, Colin J.; Buhrke, Thorsten; Braeuning, Albert

Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2020-02-01

OAAI

Schultrich, Katharina; Henderson, Colin J.; Braeuning, Albert; Buhrke, Thorsten

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

LIFE SCIENCE ALLIANCE

IF2.9

2019-10-15

OAAI

Vitobello, Antonio; Perner, Juliane; Beil, Johanna; Zhu, Jiang; Del Rio-Espinola, Alberto; Morawiec, Laurent; Westphal, Magdalena; Dubost, Valerie; Altorfer, Marc; Naumann, Ulrike; Mueller, Arne; Kapur, Karen; Borowsky, Mark; Henderson, Colin; Wolf, C. Roland; Schwarz, Michael; Moggs, Jonathan; Terranova, Remi

The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice

ARCHIVES OF TOXICOLOGY

IF6.9

2019-10-12

OAAI

Hessel-Pras, Stefanie; Braeuning, Albert; Guenther, Georgia; Adawy, Alshaimaa; Enge, Anne-Margarethe; Ebmeyer, Johanna; Henderson, Colin J.; Hengstler, Jan G.; Lampen, Alfonso; Reif, Raymond

Application of a mouse model humanized for the major pathways of drug disposition in anticancer drug development and use

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Henderson, Colin J.; Scheer, Nico; Kapelyukh, Yury; McLaren, Aileen; MacLeod, Kenneth; Rode, Anja; Lin, De; Wolf, C. Roland

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo

ARCHIVES OF TOXICOLOGY

IF6.9

2019-05-28

365

PREAI

Stock, Valerie; Boehmert, Linda; Lisicki, Elisa; Block, Rafael; Cara-Carmona, Julia; Pack, Laura Kim; Selb, Regina; Lichtenstein, Dajana; Voss, Linn; Henderson, Colin J.; Zabinsky, Elke; Sieg, Holger; Braeuning, Albert; Lampen, Alfonso

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2019-03-01

OAAI

Reed, Lindsay; Indra, Radek; Mrizova, Iveta; Moserova, Michaela; Schmeiser, Heinz H.; Wolf, C. Roland; Henderson, Colin J.; Stiborova, Marie; Phillips, David H.; Arlt, Volker M.

研究方向