Chen‐Yong Lin - Publications, H-index & Citations

Chen‐Yong Lin

department of oncology

42H指数

126论文数

6.2K被引数

收录论文 64

发表时间

Matriptase proteolysis selectively drives disassembly and internalization of the claudin-7 complex while preserving E-cadherin 基质溶酶蛋白水解选择性驱动紧密连接蛋白7复合物的解聚和内化，同时保留E-钙黏蛋白

Human Cell

IF3.1

2026-07-13

PREAI

Yu-Ling A. Kao; He-Yu Huang; Yin S. Yu; Nanxi Huang; Ya-Chin Chan; Chen-Ray Lee; Michael D. Johnson; Chen-Yong Lin

Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migration 基质溶酶-EPCAM/Trop-2轴动态调控的细胞间粘附对细胞外排、分裂和集体迁移至关重要

Cell Adhesion & Migration

IF3.5

2026-05-05

OAAI

Yu-Ling A. Kao; Qiaochu Wang; Dajun D. Lu; Shigeki Umemura; Vivien Lee; Ying Hsuan Tsai; Robert B. Barndt; Jehng‑Kang Wang; Michael D. Johnson; Chen-Yong Lin

Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase 辅酶A通过线粒体硫氧还蛋白还原酶的CoAlation作用来抵抗铁死亡。

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-10-01

OAAI

Lin, Chao-Chieh; Lin, Yi-Tzu; Chen, Ssu-Yu; Setayeshpour, Yasaman; Chen, Yubin; Dunn, Denise E.; Nguyen, Taylor; Mestre, Alexander A.; Banerjee, Adrija; Guruprasad, Lalitha; Soderblom, Erik J.; Zhang, Guo-Fang; Lin, Chen-Yong; Filonenko, Valeriy; Jeong, Suh young; Floyd, Scott R.; Hayflick, Susan J.; Gout, Ivan; Chi, Jen-Tsan

SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation

HUMAN MOLECULAR GENETICS

IF3.2

2024-01-25

PREAI

Huang, Nanxi; Wang, Qiaochu; Bernard, Robert B.; Chen, Chao-Yang; Hu, Je-Ming; Wang, Jehng-Kang; Chan, Khee-Siang; Johnson, Michael D.; Lin, Chen-Yong

HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes

HUMAN CELL

IF3.1

2023-04-19

PREAI

Lu, Dajun D.; Huang, Nanxi; Li, Sheng-Wen A.; Fang, Jessica R.; Lai, Chih-Hsin; Wang, Jehng-Kang; Chan, Khee-Siang; Johnson, Michael D.; Lin, Chen-Yong

N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity

GLYCOBIOLOGY

IF3.3

2023-01-13

OAAI

Huang, Nanxi; Wang, Qiaochu; Chen, Chao-Yang; Hu, Je-Ming; Wang, Jehng-Kang; Chang, Ping-Ying; Johnson, Michael D.; Lin, Chen-Yong

Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity

GENES & DISEASES

IF9.4

2022-07-01

OAAI

Chiu, Yi-Lin; Wu, Yi-Ying; Barndt, Robert B.; Lin, Yu-Wen; Sytwo, Hou-Ping; Cheng, Amy; Yang, Kacy; Chan, Khee-Siang; Wang, Jehng-Kang; Johnson, Michael D.; Lin, Chen-Yong

The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2

HUMAN CELL

IF3.1

2021-10-13

PREAI

Huang, Nanxi; Barndt, Robert B.; Lu, Dajun D.; Wang, Qiaochu; Huang, Shih-Ming; Wang, Jehng-Kang; Chang, Ping-Ying; Chen, Chao-Yang; Hu, Je-Ming; Su, Hui-Chen; Johnson, Michael D.; Lin, Chen-Yong

Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells

HUMAN MOLECULAR GENETICS

IF3.2

2021-06-04

OAAI

Barndt, Robert B.; Lee, Mon-Juan; Huang, Nanxi; Lu, Dajun D.; Lee, See-Chi; Du, Po-Wen; Chang, Chun-Chia; Tsai, Ping-Feng B.; Huang, Yu-Siou K.; Chang, Hao-Ming; Wang, Jehng-Kang; Lai, Chih-Hsin; Johnson, Michael D.; Lin, Chen-Yong

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes

HUMAN CELL

IF3.1

2021-01-24

PREAI

Lu, Dajun D.; Gu, Yayun; Li, Sheng-Wen A.; Barndt, Robert J.; Huang, Shih-Ming; Wang, Jehng-Kang; Su, Hui Chen; Johnson, Michael D.; Lin, Chen-Yong

Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation

HUMAN CELL

IF3.1

2020-08-10

PREAI

Jia, Bailing; Thompson, Hamishi A.; Barndt, Robert B.; Chiu, Yi-Lin; Lee, Mon-Juan; Lee, See-Chi; Wang, Jehng-Kang; Tang, Hung-Jen; Lin, Chen-Yong; Johnson, Michael D.

Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin

HUMAN CELL

IF3.1

2020-07-02

PREAI

Chang, Shun-Cheng; Chiang, Chien-Ping; Lai, Chih-Hsin; Du, Po-Wen A.; Hung, Yu-Sin; Chen, Yu-Hsuan; Yang, Hui-Yu; Fang, Hao-Yu; Lee, Shiao-Pieng; Tang, Hung-Jen; Wang, Jehng-Kang; Johnson, Michael D.; Lin, Chen-Yong

The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation

HUMAN CELL

IF3.1

2020-04-18

PREAI

Lin, Chen-Yong; Wang, Jehng-Kang; Johnson, Michael D.

Rapid Assessment of Surface Markers on Cancer Cells Using Immuno-Magnetic Separation and Multi-frequency Impedance Cytometry for Targeted Therapy

SCIENTIFIC REPORTS

IF3.9

2020-02-20

OAAI

Lin, Zhongtian; Lin, Siang-Yo; Xie, Pengfei; Lin, Chen-Yong; Rather, Gulam M.; Bertino, Joseph R.; Javanmard, Mehdi

Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2019-02-19

OAAI

Chiu, Yi-Lin; Wu, Yi-Ying; Barndt, Robert B.; Yeo, Yee Hui; Lin, Yu-Wen; Sytwo, Hou-Ping; Liu, Huan-Cheng; Xu, Yuan; Jia, Bailing; Wang, Jehng-Kang; Johnson, Michael D.; Lin, Chen-Yong

SELECTIVE INHIBITION OF PROSTASIN IN HUMAN ENTEROCYTES BY THE INTEGRAL MEMBRANE KUNITZ-TYPE SERINE PROTEASE INHIBITOR HAI-2

GASTROENTEROLOGY

IF25.1

2017-04-01

PREAI

Yeo, Yee Hui; Shiao, Frank; Liu, Li-Ching O.; Huang, Nanxi; Lai, Ying-Jung J.; Barndt, Robert J.; Tseng, Chun-Che; Wang, Jehng-Kang; Jia, Bailing; Johnson, Michael D.; Lin, Chen-Yong

Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2016-09-23

PREAI

Kanemaru, Ai; Yamamoto, Koji; Kawaguchi, Makiko; Fukushima, Tsuyoshi; Lin, Chen-Yong; Johnson, Michael D.; Camerer, Eric; Kataoka, Hiroaki

Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death

JOURNAL OF DERMATOLOGICAL SCIENCE

IF4

2016-07-01

PREAI

Chen, Chi-Yung; Chen, Cheng-Jueng; Lai, Chih-Hsin; Wu, Bai-Yao; Lee, Shiao-Pieng; Johnson, Michael D.; Ling, Chen-Yong; Wang, Jehng-Kang