Isabel Lastres‐Becker - Publications, H-index & Citations

Isabel Lastres‐Becker

CSIC

38H指数

74论文数

5.4K被引数

收录论文 29

发表时间

GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model GASDERMIN D介导的焦亡作为TAU依赖性额颞叶痴呆小鼠模型的 therapeutic target

Journal of Biomedical Science

IF12.1

2026-01-05

OAAI

Ignacio Silva-Llanes; Lilia A. Smith; Aaron Abdelkader-Guillén; José Jiménez-Villegas; David Sarrió; Gema Moreno-Bueno; Isabel Lastres-Becker

Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model 靶向CB2受体的一种新型拮抗剂可逆转TAU依赖性额颞叶痴呆小鼠模型的认知衰退、神经退行性变和焦亡。

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2025-07-01

PREAI

Silva-Llanes, Ignacio; Rodriguez-Lopez, Silvia; Gonzalez-Naranjo, Pedro; del Sastre, Eric; Lopez, Manuela G.; Paez, Juan Antonio; Campillo, Nuria; Lastres-Becker, Isabel

RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection RIPK1在tau病变中的表达和抑制: 对神经炎症和神经保护的影响

FRONTIERS IN NEUROSCIENCE

IF3.2

2025-01-27

OAAI

Silva-Llanes, Ignacio; Madruga, Enrique; Martinez, Ana; Lastres-Becker, Isabel

The Transcription Factor NRF2 Has Epigenetic Regulatory Functions Modulating HDACs, DNMTs, and miRNA Biogenesis

ANTIOXIDANTS

IF6.6

2023-03-04

OAAI

Silva-Llanes, Ignacio; Shin, Chang Hoon; Jimenez-Villegas, Jose; Gorospe, Myriam; Lastres-Becker, Isabel

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-01-05

OAAI

Martin-Camara, Olmo; Arribas, Marina; Wells, Geoffrey; Morales-Tenorio, Marcos; Martin-Requero, Angeles; Porras, Gracia; Martinez, Ana; Giorgi, Giorgio; Lopez-Alvarado, Pilar; Lastres-Becker, Isabel; Carlos Menendez, J.

Editorial: Tau Protein: Mechanisms From Health to Degeneration

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2021-11-01

OAAI

Lastres-Becker, Isabel

Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2021-05-17

OAAI

Galan-Ganga, M.; Rodriguez-Cueto, C.; Merchan-Rubira, J.; Hernandez, F.; avila, J.; Posada-Ayala, M.; Lanciego, J. L.; Luengo, E.; Lopez, M. G.; Rabano, A.; Fernandez-Ruiz, J.; Lastres-Becker, I.

Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model 在TAU病小鼠模型中通过LRRK2抑制剂的治疗来增强认知，减少TAU磷酸化和神经元保护

NEUROBIOLOGY OF AGING

IF3.5

2020-12-01

OAAI

Castro-Sanchez, Sara; Zaldivar-Diez, Josefa; Luengo, Enrique; Lopez, Manuela G.; Gil, Carmen; Martinez, Ana; Lastres-Becker, Isabel

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling

SCIENTIFIC REPORTS

IF3.9

2019-09-25

OAAI

Martin-Hurtado, Ana; Martin-Morales, Raquel; Robledinos-Anton, Natalia; Blanco, Ruth; Palacios-Blanco, Ines; Lastres-Becker, Isabel; Cuadrado, Antonio; Garcia-Gonzalo, Francesc R.

Cannabinoid CB2 Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells

CELLULAR AND MOLECULAR NEUROBIOLOGY

IF4.8

2019-08-05

OAAI

Galan-Ganga, M.; Del Rio, R.; Jimenez-Moreno, N.; Diaz-Guerra, M.; Lastres-Becker, I.

Role of MSK1 in the Induction of NF-B by the Chemokine CX3CL1 in Microglial Cells

CELLULAR AND MOLECULAR NEUROBIOLOGY

IF4.8

2019-03-04

PREAI

Galan-Ganga, Marcos; Garcia-Yague, Angel J.; Lastres-Becker, Isabel

Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

GLIA

IF5.1

2018-04-06

PREAI

Castro-Sanchez, Sara; Garcia-Yaguee, Angel J.; Lopez-Royo, Tresa; Casarejos, Maria; Luis Lanciego, Jose; Lastres-Becker, Isabel

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

ANTIOXIDANTS & REDOX SIGNALING

IF6.1

2016-07-10

224

OAAI

Lastres-Becker, Isabel; Garcia-Yague, Angel J.; Scannevin, Robert H.; Casarejos, Maria J.; Kuegler, Sebastian; Rabano, Alberto; Cuadrado, Antonio

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-05-01

283

OAAI

Cuadrado, Antonio; Martin-Moldes, Zaira; Ye, Jianping; Lastres-Becker, Isabel

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis

BRAIN

IF11.7

2013-11-23

131

OAAI

Lastres-Becker, Isabel; Innamorato, Nadia G.; Jaworski, Tomasz; Rabano, Alberto; Kuegler, Sebastian; Van Leuven, Fred; Cuadrado, Antonio

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

PSYCHONEUROENDOCRINOLOGY

IF3.6

2013-10-01

112

PREAI

Dolores Martin-de-Saavedra, Maria; Budni, Josiane; Cunha, Mauricio P.; Gomez-Rangel, Vanessa; Lorrio, Silvia; del Barrio, Laura; Lastres-Becker, Isabel; Parada, Esther; Maria Tordera, Rosa; Rodrigues, Ana Lucia S.; Cuadrado, Antonio; Lopez, Manuela G.

Nuclear Import and Export Signals Control the Subcellular Localization of Nurr1 Protein in Response to Oxidative Stress

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-02-01

OAAI

Juan Garcia-Yaguee, Angel; Rada, Patricia; Rojo, Ana I.; Lastres-Becker, Isabel; Cuadrado, Antonio

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

HUMAN MOLECULAR GENETICS

IF3.2

2012-04-18

225

PREAI

Lastres-Becker, Isabel; Ulusoy, Ayse; Innamorato, Nadia G.; Sahin, Gurdal; Rabano, Alberto; Kirik, Deniz; Cuadrado, Antonio

Nrf2 Deficiency Potentiates Methamphetamine-Induced Dopaminergic Axonal Damage and Gliosis in the Striatum

GLIA

IF5.1

2011-08-31

PREAI

Granado, Noelia; Lastres-Becker, Isabel; Ares-Santos, Sara; Oliva, Idaira; Martin, Eduardo; Cuadrado, Antonio; Moratalla, Rosario

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis 细胞凋亡信号调节激酶1的激活是百草枯诱导的细胞死亡的关键因素: Nrf2/Trx轴的调节

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2010-05-15

118

PREAI

Niso-Santano, Mireia; Gonzalez-Polo, Rosa A.; Bravo-San Pedro, Jose M.; Gomez-Sanchez, Ruben; Lastres-Becker, Isabel; Ortiz-Ortiz, Miguel A.; Soler, German; Moran, Jose M.; Cuadrado, Antonio; Fuentes, Jose M.

研究方向