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D

David A. Knowles

New York Genome Center

40H指数
187论文数
1.3W被引数
收录论文 38
发表时间
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Perplexity as a metric for isoform diversity in the human transcriptome困惑度作为衡量人类转录组异构体多样性的指标
errGenome Biology
IF9.4
err2026-09-02
err0
errOAAI
errMegan D. Schertzer; Stella H. Park; Jiayu Su; Fairlie Reese; Gloria M. Sheynkman; David A. Knowles
err分享
err收藏
Publisher Correction: A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders出版商更正：单核表达数量性状位点的荟萃分析，将遗传风险与脑部疾病联系起来
errNature Genetics
IF29
err2026-04-07
err0
PREAI
errBeomjin Jang; Kailash BP; Alex Tokolyi; Winston H. Dredge; Ashvin Ravi; Sang-Hyuk Jung; Tatsuhiko Naito; Beomsu Kim; Min Seo Kim; Minyoung Cho; Mi-So Park; Mikaela Rosen; Joel Blanchard; Jack Humphrey; David A. Knowles; Hong-Hee Won; Towfique Raj
err分享
err收藏
A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders将遗传风险与脑部疾病联系起来的单核表达数量性状基因座的荟萃分析
errNature Genetics
IF29
err2026-03-19
err0
PREAI
errBeomjin Jang; Kailash BP; Alex Tokolyi; Winston H. Dredge; Ashvin Ravi; Sang-Hyuk Jung; Tatsuhiko Naito; Beomsu Kim; Min Seo Kim; Minyoung Cho; Mi-So Park; Mikaela Rosen; Joel Blanchard; Jack Humphrey; David A. Knowles; Hong-Hee Won; Towfique Raj
err分享
err收藏
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM使用SPLISOSM从空间转录组学数据中映射同工型和调控机制
errNature Biotechnology
IF41.7
err2026-01-05
err0
errOAAI
errJiayu Su; Yiming Qu; Megan Schertzer; Haochen Yang; Jiahao Jiang; Tenzin Lhakhang; Theodore M. Nelson; Stella Park; Qiliang Lai; Xi Fu; Seung-won Choi; David A. Knowles; Raul Rabadan
err分享
err收藏
Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells利用干预数据进行大规模因果发现，为K562细胞中的基因网络结构提供了见解。
errNature Communications
IF15.7
err2025-10-31
err0
errOAAI
errBrielin C. Brown; Alex Tokolyi; John A. Morris; Tuuli Lappalainen; David A. Knowles
err分享
err收藏
Inferring fungal cis-regulatory networks from genome sequences via unsupervised and interpretable representation learning通过无监督且可解释的表示学习，从基因组序列推断真菌顺式调控网络
errGENETICS
IF5.1
err2025-10-01
err0
errOAAI
errMoses, Alan M.; Stajich, Jason E.; Gasch, Audrey P.; Knowles, David A.
err分享
err收藏
Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyere利用功能注释，使用Gruyere将阿尔茨海默病相关的稀有变异进行映射。
erramerican journal of human genetics
IF0
err2025-08-20
err0
PREAI
errAnjali Das; Chirag Lakhani; Chloé Terwagne; Jui-Shan T. Lin; Tatsuhiko Naito; Towfique Raj; David A. Knowles
err分享
err收藏
Deriving Mendelian Randomization-based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder基于孟德尔随机化的脑成像表型与双相障碍因果网络的推导
errbiological psychiatry cognitive neuroscience and neuroimaging
IF0
err2025-08-05
err0
errOAAI
errShane O'Connell; Brielin C. Brown; Dara M. Cannon; Pilib Ó. Broin; Nadine Parker; Dag Alnæs; Lars T. Westlye; Saikat Banerjee; Leila Nabulsi; Emma Corley; Ole A. Andreassen; David A. Knowles; Niamh Mullins
err分享
err收藏
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox使用统一的计算和实验工具箱进行Cas13d-mediated亚型特异性RNA敲低
errNature Communications
IF15.7
err2025-07-29
err0
errOAAI
errMegan D. Schertzer; Andrew Stirn; Keren Isaev; Laura Pereira; Stella H. Park; Anjali Das; Aline Réal; Erin D. Jeffery; Claire Harbison; Hans-Hermann Wessels; Gloria M. Sheynkman; Neville E. Sanjana; David A. Knowles
err分享
err收藏
Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice儿童交替性偏瘫相关Atp1a3基因突变揭示小鼠中多样的神经学改变
errNeurobiology of Disease
IF5.6
err2025-05-15
err0
errOAAI
errMarkus Terrey; Georgii Krivoshein; Scott I. Adamson; Elena Arystarkhova; Laura Anderson; John Szwec; Shelby McKee; Holly Jones; Sara Perkins; Vijay Selvam; Pierre-Alexandre Piec; Dweet Chhaya; Ari Dehn; Aamir Zuberi; Stephen A. Murray; Natalia S. Morsci; Kathleen J. Sweadner; David A. Knowles; Else A. Tolner; Arn M.J.M. van den Maagdenberg; Cathleen M. Lutz
err分享
err收藏
Vector embeddings by sequence similarity and context for improved compression, similarity search, clustering, organization, and manipulation of cDNA libraries基于序列相似性和上下文的向量嵌入，用于改进cDNA文库的压缩、相似性搜索、聚类、组织和管理。
errcomputational chemistry
IF3.1
err2025-02-01
err0
errOAAI
errUm, Daniel H.; Knowles, David A.; Kaiser, Gail E.
err分享
err收藏
DERIVING CAUSAL NETWORKS OF BRAIN IMAG-ING PHENOTYPES AND BIPOLAR DISORDER USING MENDELIAN RANDOMIZATION
errEUROPEAN NEUROPSYCHOPHARMACOLOGY
IF6.7
err2024-10-01
err0
PREAI
errO'Connell, Shane; Mullins, Niamh; Brown, Brielin; Knowles, David
err分享
err收藏
A Bayesian framework for inferring dynamic intercellular interactions from time-series single-cell data
errGENOME RESEARCH
IF5.5
err2024-09-05
err1
errOAAI
errPark, Cameron; Mani, Shouvik; Beltran-Velez, Nicolas; Maurer, Katie; Huang, Teddy; Li, Shuqiang; Gohil, Satyen; Livak, Kenneth J.; Knowles, David A.; Wu, Catherine J.; Azizi, Elham
err分享
err收藏
Smoother: a unified and modular framework for incorporating structural dependency in spatial omics data平滑: 一个统一的模块化框架，用于在空间组学数据中纳入结构依赖性
errGENOME BIOLOGY
IF9.4
err2023-12-18
err2
errOAAI
errSu, Jiayu; Reynier, Jean-Baptiste; Fu, Xi; Zhong, Guojie; Jiang, Jiahao; Escalante, Rydberg Supo; Wang, Yiping; Aparicio, Luis; Izar, Benjamin; Knowles, David A.; Rabadan, Raul
err分享
err收藏
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
errCELL STEM CELL
IF20.4
err2023-09-01
err18
errOAAI
errCortes-Lopez, Mariela; Chamely, Paulina; Hawkins, Allegra G.; Stanley, Robert F.; Swett, Ariel D.; Ganesan, Saravanan; Mouhieddine, Tarek H.; Dai, Xiaoguang; Kluegel, Lloyd; Chen, Celine; Batta, Kiran; Furer, Nili; Vedula, Rahul S.; Beaulaurier, John; Drong, Alexander W.; Hickey, Scott; Dusaj, Neville; Mullokandov, Gavriel; Stasiw, Adam M.; Su, Jiayu; Chaligne, Ronan; Juul, Sissel; Harrington, Eoghan; Knowles, David A.; Potenski, Catherine J.; Wiseman, Daniel H.; Tanay, Amos; Shlush, Liran; Lindsley, Robert C.; Ghobrial, Irene M.; Taylor, Justin; Abdel-Wahab, Omar; Gaiti, Federico; Landau, Dan A.
err分享
err收藏
Multiset correlation and factor analysis enables exploration of multi-omics data
errCELL GENOMICS
IF9
err2023-08-01
err2
errOAAI
errBrown, Brielin C.; Wang, Collin; Kasela, Silva; Aguet, Francois; Nachun, Daniel C.; Taylor, Kent D.; Tracy, Russell P.; Durda, Peter; Liu, Yongmei; Johnson, W. Craig; Van Den Berg, David; Gupta, Namrata; Gabriel, Stacy; Smith, Joshua D.; Gerzsten, Robert; Clish, Clary; Wong, Quenna; Papanicolau, George; Blackwell, Thomas W.; Rotter, Jerome I.; Rich, Stephen S.; Barr, R. Graham; Ardlie, Kristin G.; Knowles, David A.; Lappalainen, Tuuli
err分享
err收藏
Prediction of on-target and off-target activity of CRISPR-Cas13d guide RNAs using deep learning
errNATURE BIOTECHNOLOGY
IF41.7
err2023-07-03
err35
PREAI
errWessels, Hans-Hermann; Stirn, Andrew; Mendez-Mancilla, Alejandro; Kim, Eric J.; Hart, Sydney K.; Knowles, David A.; Sanjana, Neville E.
err分享
err收藏
Computational models of dopamine release measured by fast scan cyclic voltammetry in vivo
errPNAS NEXUS
IF3.8
err2023-02-10
err2
errOAAI
errShashaank, N.; Somayaji, Mahalakshmi; Miotto, Mattia; Mosharov, Eugene V.; Makowicz, Emily A.; Knowles, David A.; Ruocco, Giancarlo; Sulzer, David L.
err分享
err收藏
Using epigenomics to understand cellular responses to environmental influences in diseases
errPLOS GENETICS
IF3.7
err2023-01-19
err5
errOAAI
errWattacheril, Julia J.; Raj, Srilakshmi; Knowles, David A.; Greally, John M.
err分享
err收藏
Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2021-12-01
err11
errOAAI
errBrown, Brielin C.; Knowles, David A.
err分享
err收藏

研究方向

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