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M

Mikael Simons

german center for neurodegenerative diseases
H指数:84
被引数:3.5万

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Chronic progressive demyelination induces a microglial state with lysosomal dysfunction

慢性进行性脱髓鞘诱导具有溶酶体功能障碍的小胶质细胞状态

Nature Neuroscience
IF20
2026-10-260
OAAI
Stefan A. Berghoff; Lena Spieth; Simona Vitale; Lennart Schlaphoff; Martin Zirngibl; Niklas Junker; Alan-Charles Dean; Lu Liu; Alkmini Damkou; Stefan Roth; Charlene-Annett Hurler; Leon Hosang; Katrin Perez Anderson; Simon Besson-Girard; Marvin Reich; Astrid Feiten; Ludwig Huber; Christoph Müller; Georg Kislinger; Lina Dinkel; Yakum B. Nkeh; Janos Groh; Anna Williams; Arthur Liesz; Martina Schifferer; Gesine Saher; Klaus-Armin Nave; Sarah Jäkel; Sabina Tahirovic; Martin Giera; Ozgun Gokce; Mikael Simons
Author Correction: T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis

作者更正：T细胞介导的小胶质细胞活化触发了阿尔茨海默病小鼠模型中的髓鞘病变

Nature Neuroscience
IF20
2026-10-130
OAAI
Shreeya Kedia; Hao Ji; Ruoqing Feng; Peter Androvic; Lena Spieth; Lu Liu; Jonas Franz; Hanna Zdiarstek; Katrin Perez Anderson; Cem Kaboglu; Qian Liu; Nicola Mattugini; Fatma Cherif; Danilo Prtvar; Ludovico Cantuti-Castelvetri; Arthur Liesz; Martina Schifferer; Christine Stadelmann; Sabina Tahirovic; Ozgun Gokce; Mikael Simons
Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake

内皮大麻素CB1受体缺陷可降低剪切应力诱导的动脉炎症和脂质摄取

Nature Communications
IF15.7
2026-07-070
OAAI
Bingni Chen; Aishvaryaa Prabhu; Guo Li; Anna Kaltenbach; Yong Wang; George Shakir; Lucia Natarelli; Remco Megens; Yvonne Jansen; Srishti Ramanathan; Martina Geiger; Alexander Faussner; Michael Hristov; Daniel Richter; Xinyu Di; Mario van der Stelt; Vasiliki Triantafyllidou; Zhaolong Li; Nadja Sachs; Valentina Paloschi; Lars Maegdefessel; Susanna M. Hofmann; Martina Schifferer; Mikael Simons; Christian Weber; Donato Santovito; Stephan Herzig; Raquel Guillamat Prats; Sabine Steffens
Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET

使用[18F]PI-2620 PET对进行性核上性麻痹中tau聚集的纵向监测

Alzheimer's & Dementia
IF0
2026-02-240
OAAI
Johannes Gnörich; Julia Kusche-Palenga; Carla Palleis; Antonia Neubauer; Lukas Frontzkowski; Alexander Jäck; Agnes Kling; Theresa Bauer; Hannah Eyob; Katharina Probst; Sebastian N. Roemer-Cassiano; Alexander M. Bernhardt; Sabrina Katzdobler; Lena Marth; Mirlind Zaganjori; Franziska Hopfner; Andreas Zwergal; Jan Häckert; Michael Rullmann; Osama Sabri; Henryk Barthel; Sophia Stöcklein; Rudolf A. Werner; Mikael Simons; Johannes Levin; Jochen Herms; Nicolai Franzmeier; Günter U. Höglinger; Matthias Brendel; for the German Imaging Initiative for Tauopathies (GII4T)
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动功效至关重要

Nature Communications
IF15.7
2026-01-240
OA
Astrid F. Feiten; Kilian Dahm; Kai Schlepckow; Bettina van Lengerich; Jung H. Suh; Anika Reifschneider; Benedikt Wefers; Laura M. Bartos; Karin Wind-Mark; Lis de Weerd; Thomas Ulas; Elena De-Domenico; Pia Grundschöttel; Stefan Paulusch; Benjamin Tast; Tamisa Honda; Stephan A. Müller; Matthias Becker; Igor Khalin; Alessio Ricci; Arthur Liesz; Bettina Brunner; Claudia Krenner; Katrin Buschmann; Brigitte Nuscher; Lena Spieth; Niklas Junker; Stefan A. Berghoff; Sonnet S. Davis; Jonas J. Neher; Wolfgang Wurst; Nikolaus Plesnila; Joseph W. Lewcock; Mikael Simons; Stefan F. Lichtenthaler; Gilbert Di Paolo; Matthias Brendel; Anja Capell; Kathryn M. Monroe; Joachim L. Schultze; Christian Haass
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling

卒中风险基因Foxf2通过Tie2信号维持脑内皮细胞功能

Nature Neuroscience
IF20
2025-12-150
OAAI
Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Mihail Ivilinov Todorov; Fatma Burcu Seker; Simon Frerich; Filippo M. Cernilogar; Luise Schröger; Rainer Malik; Jiayu Cao; Gemma Llovera; Stefan Roth; Ulrike Schillinger; Martina Schifferer; Azadeh Reyahi; Dennis Crusius; Liliana D. Pedro; Mikael Simons; Peter Carlsson; Ali Ertürk; Arthur Liesz; Gunnar Schotta; Nikolaus Plesnila; Stefan F. Lichtenthaler; Dominik Paquet; Martin Dichgans
In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation

体内CRISPR筛选揭示了神经炎症中巨噬细胞状态的调控

Nature Neuroscience
IF20
2025-12-040
OAAI
Clara de la Rosa; Arek Kendirli; Seren Baygün; Franz Bauernschmitt; Anna S. Thomann; Ilgin Kisioglu; Daniela Beckmann; Yves Carpentier Solorio; Veronika Pfaffenstaller; Yi-Heng Tai; Niel Mehraein; Paula Sanchez; Lena Spieth; Lisa Ann Gerdes; Eduardo Beltran; Klaus Dornmair; Mikael Simons; Anneli Peters; Marc Schmidt-Supprian; Martin Kerschensteiner
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions

单细胞空间转录组学分析定义了慢性活动性多发性硬化病灶中的致病性炎症微环境

Immunity
IF26.3
2025-10-290
OAAI
Ruoqing Feng; Lena Spieth; Lu Liu; Stefan Berghoff; Jonas Franz; Qian Liu; Zhen Wang; Vini Tiwari; Simona Vitale; Simon Frerich; Sergi Florensa; Niklas Junker; Ludwig Huber; Marco Keller; Christoph Müller; Franz Bracher; Xiaoke Ge; Patrick C.N. Rensen; Gijs Kooij; Leon Hosang; Serhii Chornyi; Martin Dichgans; Ozgun Gokce; Gesine Saher; Christine Stadelmann; Martin Giera; Janos Groh; Mikael Simons
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-12-040
PRE
Dinkel, Lina; Hummel, Selina; Zenatti, Valerio; Malara, Mariagiovanna; Tillmann, Yannik; Colombo, Alessio; Monasor, Laura Sebastian; Suh, Jung H.; Logan, Todd; Roth, Stefan; Paeger, Lars; Hoffelner, Patricia; Bludau, Oliver; Schmidt, Andree; Mueller, Stephan A.; Schifferer, Martina; Nuscher, Brigitte; Njavro, Jasenka Rudan; Prestel, Matthias; Bartos, Laura M.; Wind-Mark, Karin; Slemann, Luna; Hoermann, Leonie; Kunte, Sebastian T.; Gnoerich, Johannes; Lindner, Simon; Simons, Mikael; Herms, Jochen; Paquet, Dominik; Lichtenthaler, Stefan F.; Bartenstein, Peter; Franzmeier, Nicolai; Liesz, Arthur; Grosche, Antje; Bremova-Ertl, Tatiana; Catarino, Claudia; Beblo, Skadi; Bergner, Caroline; Schneider, Susanne A.; Strupp, Michael; Di Paolo, Gilbert; Brendel, Matthias; Tahirovic, Sabina
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology

小胶质细胞中的载脂蛋白E聚集引发阿尔茨海默氏病病理学

IMMUNITY
IF26.3
2024-11-012
OA
Kaji, Seiji; Berghoff, Stefan A.; Spieth, Lena; Schlaphoff, Lennart; Sasmita, Andrew O.; Vitale, Simona; Bueschgens, Luca; Kedia, Shreeya; Zirngibl, Martin; Nazarenko, Taisiia; Damkou, Alkmini; Hosang, Leon; Depp, Constanze; Kamp, Frits; Scholz, Patricia; Ewers, David; Giera, Martin; Ischebeck, Till; Wurst, Wolfgang; Wefers, Benedikt; Schifferer, Martina; Willem, Michael; Nave, Klaus-Armin; Haass, Christian; Arzberger, Thomas; Jaekel, Sarah; Wirths, Oliver; Saher, Gesine; Simons, Mikael
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease
MOLECULAR NEURODEGENERATION
IF17.5
2024-09-050
OAAI
Zatcepin, Artem; Gnoerich, Johannes; Rauchmann, Boris-Stephan; Bartos, Laura M.; Wagner, Stephan; Franzmeier, Nicolai; Malpetti, Maura; Xiang, Xianyuan; Shi, Yuan; Parhizkar, Samira; Grosch, Maximilian; Wind-Mark, Karin; Kunte, Sebastian T.; Beyer, Leonie; Meyer, Carolin; Broesamle, Desiree; Wendeln, Ann-Christin; Osei-Sarpong, Collins; Heindl, Steffanie; Liesz, Arthur; Stoecklein, Sophia; Biechele, Gloria; Finze, Anika; Eckenweber, Florian; Lindner, Simon; Rominger, Axel; Bartenstein, Peter; Willem, Michael; Tahirovic, Sabina; Herms, Jochen; Buerger, Katharina; Simons, Mikael; Haass, Christian; Rupprecht, Rainer; Riemenschneider, Markus J.; Albert, Nathalie L.; Beyer, Marc; Neher, Jonas J.; Paeger, Lars; Levin, Johannes; Hoeglinger, Guenter U.; Perneczky, Robert; Ziegler, Sibylle I.; Brendel, Matthias
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system

先天免疫训练恢复促修复髓系功能促进老年中枢神经系统髓鞘再生

IMMUNITY
IF26.3
2024-09-010
OAAI
Tiwari, Vini; Prajapati, Bharat; Asare, Yaw; Damkou, Alkmini; Ji, Hao; Liu, Lu; Naser, Nawraa; Gouna, Garyfallia; Leszczynska, Katarzyna B.; Mieczkowski, Jakub; Dichgans, Martin; Wang, Qing; Kawaguchi, Riki; Shi, Zechuan; Swarup, Vivek; Geschwind, Daniel H.; Prinz, Marco; Gokce, Ozgun; Simons, Mikael
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-06-050
PRE
Reich, Marvin; Simon, Matthew J.; Polke, Beate; Paris, Inaki; Werner, Georg; Schrader, Christian; Spieth, Lena; Davis, Sonnet S.; Robinson, Sophie; de Melo, Gabrielly Lunkes; Schlaphoff, Lennart; Buschmann, Katrin; Berghoff, Stefan; Logan, Todd; Nuscher, Brigitte; de Weerd, Lis; Edbauer, Dieter; Simons, Mikael; Suh, Jung H.; Sandmann, Thomas; Kariolis, Mihalis S.; Devos, Sarah L.; Lewcock, Joseph W.; Paquet, Dominik; Capell, Anja; Di Paolo, Gilbert; Haass, Christian

研究方向

暂未获取到该数据
M
Martina Schifferer
H 指数:26论文数:94被引数:4,183
L
Ludovico Cantuti‐Castelvetri
H 指数:28论文数:45被引数:6,890
K
Klaus‐Armin Nave
H 指数:111论文数:548被引数:4.7万
Ö
Özgün Gökçe
H 指数:34论文数:105被引数:9,493
N
Nicolas Snaidero
H 指数:23论文数:38被引数:4,566
W
Wiebke Möbius
H 指数:71论文数:228被引数:1.9万
C
Christian Haass
H 指数:135论文数:669被引数:7.5万
S
Stefan F. Lichtenthaler
H 指数:65论文数:326被引数:1.3万
A
Anja Schneider
H 指数:63论文数:469被引数:2.0万
L
Lu Liu
H 指数:30论文数:181被引数:3,556