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R

Richard T. Timms

Brigham and Women's Hospital

H指数:28

被引数:3,937

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Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis

蛋白酶体范围的C-degron活性谱分析将CTLH E3泛素连接酶复合物的条件性调控与核糖体生物发生联系起来

IF16.6

2026-10-200

OA

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance

LRRC58定义了对半胱氨酸丰度敏感的E3泛素连接酶复合物

IF16.6

2026-06-190

OA

Degrons: defining the rules of protein degradation

Degrons: 定义蛋白质降解的规则

Nature Reviews Molecular Cell Biology

IF90.2

2025-07-140

PRE

Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression

THAP1基因的失活突变通过抑制PSMB5表达损害蛋白酶体功能

NATURE COMMUNICATIONS

IF15.7

2025-02-101

OA

Competition between two HUSH complexes orchestrates the immune response to retroelement invasion

IF16.6

2024-08-015

OA

Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability

JOURNAL OF CELL BIOLOGY

IF6.4

2024-06-140

PRE

Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase

CRL2FEM1B泛素连接酶的 Ψ-pro/c-degron识别机制

NATURE COMMUNICATIONS

IF15.7

2024-04-263

OAAI

Defining E3 ligase-substrate relationships through multiplex CRISPR screening (vol 25, pg 1535, 2023)

NATURE CELL BIOLOGY

IF19.1

2023-12-190

OAAI

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping ( Vol 83 , pg 3377 , 2023)

IF16.6

2023-11-010

OAAI

Defining E3 ligase-substrate relationships through multiplex CRISPR screening

NATURE CELL BIOLOGY

IF19.1

2023-09-2115

OAAI

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping

IF16.6

2023-09-0113

OA

Ubiquitin-independent proteasomal degradation driven by C-degron pathways

IF16.6

2023-06-0124

OAAI

Integration of Elf-4 into Stem/Progenitor and Erythroid Regulatory Networks through Locus-Wide Chromatin Studies Coupled with In Vivo Functional Validation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-205

OAAI

Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-2060

OAAI

High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform

使用功能遗传学筛选平台的高通量，靶向MHC I类免疫抗体

NATURE BIOTECHNOLOGY

IF41.7

2023-01-0212

OA

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

调节蛋白质稳定性在营养物质控制TFE3和MITF中的核心作用

IF16.6

2023-01-0119

OAAI

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

IF0

2022-04-0585

PRE

Systematic characterization of mutations altering protein degradation in human cancers

IF16.6

2021-03-0141

OAAI

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

NATURE COMMUNICATIONS

IF15.7

2020-10-0257

OAAI

Periphilin self-association underpins epigenetic silencing by the HUSH complex

NUCLEIC ACIDS RESEARCH

IF13.1

2020-09-2515

OAAI