未登录 Targeting the Sodium-Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Schneider, Constanze; Spaink, Hermes; Alexe, Gabriela; Dharia, Neekesh V.; Meyer, Ashleigh; Merickel, Lucy A.; Khalid, Delan; Scheich, Sebastian; Haeupl, Bjoern; Staudt, Louis M.; Oellerich, Thomas; Stegmaier, Kimberly 分享 收藏
Clinical and immunophenotype correlating with response to immunotherapy in paediatric patients with primary liver carcinoma. A case series O'Neill, Allison F.; Church, Alanna J.; Feraco, Angela; Spidle, Jennifer; Wall, Catherine B.; Kim, Heung Bae; Elisofon, Scott; Vakili, Khashayar; Pimkin, Max; Dharia, Neekesh, V; Shelman, Nathan R.; Perez-Atayde, Antonio R.; Rodriguez-Galindo, Carlos 分享 收藏
SMARCAL1 is a novel synthetic lethal target in ALT plus osteosarcoma and neuroblastoma Wierdl, Monika; Catlett, Jerrel L.; Ocasio-Martinez, Nicole; Johnson, Jon D.; Herman, Amy; Dharia, Neekesh V.; Alexe, Gabriela; Sweet-Cordero, E. Alejandro; Bernstein, Emily; Stegmaier, Kimberly; Guenther, Lillian M. 分享 收藏
STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma STAT3将激活的酪氨酸激酶信号与间变性大细胞淋巴瘤的致癌核心转录调控电路耦合 Prutsch, Nicole; He, Shuning; Berezovskaya, Alla; Durbin, Adam D.; Dharia, Neekesh V.; Maher, Kelsey A.; Matthews, Jamie D.; Hare, Lucy; Turner, Suzanne D.; Stegmaier, Kimberly; Kenner, Lukas; Merkel, Olaf; Look, A. Thomas; Abraham, Brian J.; Zimmerman, Mark W. 分享 收藏
SMARCAL1 is a selective dependency and a novel synthetic lethal target in ATRX/DAXX mutant ALT plus osteosarcoma and neuroblastoma Wierdl, Monika; Catlett, Jerrel L.; Ocasio-Martinez, Nicole; Johnson, John D.; Herman, Amy; Dharia, Neekesh V.; Alexe, Gabriela; Sweet-Cordero, E. Alejandro; Bernstein, Emily; Stegmaier, Kimberly; Guenther, Lillian M. 分享 收藏
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial Divarasib联合西妥昔单抗治疗KRAS G12C-positive结直肠癌: 1b期临床试验 Desai, Jayesh; Alonso, Guzman; Kim, Se Hyun; Cervantes, Andres; Karasic, Thomas; Medina, Laura; Shacham-Shmueli, Einat; Cosman, Rasha; Falcon, Alejandro; Gort, Eelke; Guren, Tormod; Massarelli, Erminia; Miller Jr, Wilson H.; Paz-Ares, Luis; Prenen, Hans; Amatu, Alessio; Cremolini, Chiara; Kim, Tae Won; Moreno, Victor; Ou, Sai-Hong I.; Passardi, Alessandro; Sacher, Adrian; Santoro, Armando; Stec, Rafal; Ulahannan, Susanna; Arbour, Kathryn; Lorusso, Patricia; Luo, Jia; Patel, Manish R.; Choi, Yoonha; Shi, Zhen; Mandlekar, Sandhya; Lin, Mark T.; Royer-Joo, Stephanie; Chang, Julie; Jun, Tomi; Dharia, Neekesh V.; Schutzman, Jennifer L.; Han, Sae-Won 分享 收藏
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation 单药Divarasib (GDC-6036) 在具有KRAS G12C突变的实体瘤中 Sacher, Adrian; LoRusso, Patricia; Patel, Manish R.; Miller, Wilson H.; Garralda, Elena; Forster, Martin D.; Santoro, Armando; Falcon, Alejandro; Kim, Tae Won; Paz-Ares, Luis; Bowyer, Samantha; de Miguel, Maria; Han, Sae-Won; Krebs, Matthew G.; Lee, Jong-Seok; Cheng, Michael L.; Arbour, Kathryn; Massarelli, Erminia; Choi, Yoonha; Shi, Zhen; Mandlekar, Sandhya; Lin, Mark T.; Royer-Joo, Stephanie; Chang, Julie; Dharia, Neekesh V.; Schutzman, Jennifer L.; Desai, Jayesh 分享 收藏
BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA BAF复杂扰动作为H3K27M小儿神经胶质瘤的新治疗机会 Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh; Hoffman, Samantha; Kugener, Guillaume; Shaw, McKenzie; Hack, Olivia; Dempster, Joshua; Lareau, Caleb; Quezada, Michael; Stanton, Ann-Catherine; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John; Root, David; Anastas, Jamie; Jones, Kristen; Conway, Amy; Stopka, Sylwia; Regan, Michael; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Mathewson, Nathan; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Nguyen, Quang-De; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G. 分享 收藏
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias Simoes, Ricardo de Matos; Shirasaki, Ryosuke; Downey-Kopyscinski, Sondra L.; Matthews, Geoffrey M.; Barwick, Benjamin G.; Gupta, Vikas A.; Dupere-Richer, Daphne; Yamano, Shizuka; Hu, Yiguo; Sheffer, Michal; Dhimolea, Eugen; Dashevsky, Olga; Gandolfi, Sara; Ishiguro, Kazuya; Meyers, Robin M.; Bryan, Jordan G.; Dharia, Neekesh V.; Hengeveld, Paul J.; Bruggenthies, Johanna B.; Tang, Huihui; Aguirre, Andrew J.; Sievers, Quinlan L.; Ebert, Benjamin L.; Glassner, Brian J.; Ott, Christopher J.; Bradner, James E.; Kwiatkowski, Nicholas P.; Auclair, Daniel; Levy, Joan; Keats, Jonathan J.; Groen, Richard W. J.; Gray, Nathanael S.; Culhane, Aedin C.; McFarland, James M.; Dempster, Joshua M.; Licht, Jonathan D.; Boise, Lawrence H.; Hahn, William C.; Vazquez, Francisca; Tsherniak, Aviad; Mitsiades, Constantine S. 分享 收藏
Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation Desai, Jayesh; Han, Sae-Won; Lee, Jong-Seok; Shacham-Shmueli, Einat; Massarelli, Erminia; Cervantes, Andres; Garralda, Elena; Falcon, Alejandro; Miller, Wilson H.; Gort, Eelke; Karasic, Thomas; Siena, Salvatore; Stec, Rafal; Medina, Laura; Paz-Arez, Luis; Delmonte, Angelo; Sacher, Adrian; Prenen, Hans; Forster, Martin; Kim, Tae Won; Krebs, Matthew G.; Cosman, Rasha; Choi, Yoonha; Mandlekar, Sandhya; Lin, Mark T.; Yau, Kenneth K.; Chang, Julie; Royer-Joo, Stephanie; Dharia, Neekesh V.; Schutzman, Jennifer L.; Patel, Manish 分享 收藏
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma ETS转录因子ETV6抑制ews-fli促进Ewing肉瘤的转录活性 Lu, Diana Y. Y.; Ellegast, Jana M.; Ross, Kenneth N.; Malone, Clare F.; Lin, Shan; Mabe, Nathaniel W.; Dharia, Neekesh V.; Meyer, Ashleigh; Conway, Amy; Su, Angela H. H.; Selich-Anderson, Julia; Taslim, Cenny; Byrum, Andrea K.; Seong, Bo Kyung A.; Adane, Biniam; Gray, Nathanael S.; Rivera, Miguel N.; Lessnick, Stephen L.; Stegmaier, Kimberly 分享 收藏
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria C.; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh, V; Li, Deyao; Hoffman, Samantha E.; Kugener, Guillaume; Shaw, McKenzie L.; Mire, Hafsa M.; Hack, Olivia A.; Dempster, Joshua M.; Lareau, Caleb; Dai, Lingling; Sigua, Logan H.; Quezada, Michael A.; Stanton, Ann-Catherine J.; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John G.; Root, David E.; Anastas, Jamie N.; Jones, Kristen L.; Conway, Amy Saur; Stopka, Sylwia; Regan, Michael S.; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Jerome, William P.; Mathewson, Nathan D.; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Quang-De Nguyen; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G. 分享 收藏
Transcriptional Plasticity Drives Leukemia Immune Escape Eagle, Kenneth; Harada, Taku; Kalfon, Jeremie; Perez, Monika W.; Heshmati, Yaser; Ewers, Jazmin; Koren, Jost Vrabic; Dempster, Joshua M.; Kugener, Guillaume; Paralkar, Vikram R.; Lin, Charles Y.; V. Dharia, Neekesh; Stegmaier, Kimberly; Orkin, Stuart H.; Pimkin, Maxim 分享 收藏
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Ellegast, Jana M.; Alexe, Gabriela; Hamze, Amanda; Lin, Shan; Uckelmann, Hannah J.; Rauch, Philipp J.; Pimkin, Maxim; Ross, Linda S.; Dharia, Neekesh, V; Robichaud, Amanda L.; Conway, Amy Saur; Khalid, Delan; Perry, Jennifer A.; Wunderlich, Mark; Benajiba, Lina; Pikman, Yana; Nabet, Behnam; Gray, Nathanael S.; Orkin, Stuart H.; Stegmaier, Kimberly 分享 收藏
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma Durbin, Adam D.; Wang, Tingjian; Wimalasena, Virangika K.; Zimmerman, Mark W.; Li, Deyao; Dharia, Neekesh, V; Mariani, Luca; Shendy, Noha A. M.; Nance, Stephanie; Patel, Anand G.; Shao, Ying; Mundada, Maya; Maxham, Lily; Park, Paul M. C.; Sigua, Logan H.; Morita, Ken; Conway, Amy Saur; Robichaud, Amanda L.; Perez-Atayde, Antonio R.; Bikowitz, Melissa J.; Quinn, Taylor R.; Wiest, Olaf; Easton, John; Schonbrunn, Ernst; Bulyk, Martha L.; Abraham, Brian J.; Stegmaier, Kimberly; Look, A. Thomas; Qi, Jun 分享 收藏
An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML AML治疗靶点优先的体内CRISPR筛选平台 Lin, Shan; Larrue, Clement; Scheidegger, Nastassja K.; Seong, Bo Kyung A.; Dharia, Neekesh, V; Kuljanin, Miljan; Wechsler, Caroline S.; Kugener, Guillaume; Robichaud, Amanda L.; Conway, Amy Saur; Mashaka, Thelma; Mouche, Sarah; Adane, Biniam; Ryan, Jeremy A.; Mancias, Joseph D.; Younger, Scott T.; Piccioni, Federica; Lee, Lynn H.; Wunderlich, Mark; Letai, Anthony; Tamburini, Jerome; Stegmaier, Kimberly 分享 收藏
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q (vol 33, pg 108493, 2020) Neggers, Jasper E.; Paolella, Brenton R.; Asfaw, Adhana; Rothberg, Michael V.; Skipper, Thomas A.; Yang, Annan; Kalekar, Radha L.; Krill-Burger, John M.; Dharia, Neekesh V.; Kugener, Guillaume; Kalfon, Jeremie; Yuan, Chen; Dumont, Nancy; Gonzalez, Alfredo; Abdusamad, Mai; Li, Yvonne Y.; Spurr, Liam F.; Wu, Westley W.; Durbin, Adam D.; Wolpin, Brian M.; Piccioni, Federica; Root, David E.; Boehm, Jesse S.; Cherniack, Andrew D.; Tsherniak, Aviad; Hong, Andrew L.; Hahn, William C.; Stegmaier, Kimberly; Golub, Todd R.; Vazquez, Francisca; Aguirre, Andrew J. 分享 收藏
Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival Gillani, Riaz; Seong, Bo Kyung A.; Crowdis, Jett; Conway, Jake R.; Dharia, Neekesh V.; Alimohamed, Saif; Haas, Brian J.; Han, Kyuho; Park, Jihye; Dietlein, Felix; He, Meng Xiao; Imamovic, Alma; Ma, Clement; Bassik, Michael C.; Boehm, Jesse S.; Vazquez, Francisca; Gusev, Alexander; Liu, David; Janeway, Katherine A.; McFarland, James M.; Stegmaier, Kimberly; Van Allen, Eliezer M. 分享 收藏
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer Malone, Clare F.; Dharia, Neekesh, V; Kugener, Guillaume; Forman, Alexandra B.; Rothberg, Michael, V; Abdusamad, Mai; Gonzalez, Alfredo; Kuljanin, Miljan; Robichaud, Amanda L.; Conway, Amy Saur; Dempster, Joshua M.; Paolella, Brenton R.; Dumont, Nancy; Hovestadt, Volker; Mancias, Joseph D.; Younger, Scott T.; Root, David E.; Golub, Todd R.; Vazquez, Francisca; Stegmaier, Kimberly 分享 收藏
A first-generation pediatric cancer dependency map Dharia, Neekesh, V; Kugener, Guillaume; Guenther, Lillian M.; Malone, Clare F.; Durbin, Adam D.; Hong, Andrew L.; Howard, Thomas P.; Bandopadhayay, Pratiti; Wechsler, Caroline S.; Fung, Iris; Warren, Allison C.; Dempster, Joshua M.; Krill-Burger, John M.; Paolella, Brenton R.; Moh, Phoebe; Jha, Nishant; Tang, Andrew; Montgomery, Philip; Boehm, Jesse S.; Hahn, William C.; Roberts, Charles W. M.; McFarland, James M.; Tsherniak, Aviad; Golub, Todd R.; Vazquez, Francisca; Stegmaier, Kimberly 分享 收藏
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