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T

Timothy J. Shafer

Center for Computational Toxicology and Exposure
H指数:47
被引数:6,806

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Integrating mechanistic data to contextualize in vivo apical observations using the developmental neurotoxicity in vitro battery

整合机制数据以利用发育神经毒性体外组合方法对体内顶端观察结果进行背景化处理

Toxicological Sciences
IF4.1
2026-07-290
OAAI
Brianna L Jackson; Yaoxing Wu; Kian Afsharian; Christopher Schlosser; Angela H Hofstra; Laura M Minnema; Jördis Klose; Ellen Fritsche; Manasvinee Mayil Vahanan; Timothy J Shafer; Kelly E Carstens; Agnes L Karmaus
Detection of seizurogenic compounds in human and rat neurons in vitro: A multi-laboratory, multi-model assessment

在体外表征人及大鼠神经元中致痫化合物的检测：一项多实验室、多模型的评估

Neurotoxicology
IF3.9
2026-07-010
OAAI
Roberts, Ruth; Blinova, Ksenia; Carlson, Coby; Cato, Matthew; Czysz, Katherine; Feaster, Tromondae K.; Han, Xiaobo; Ishibashi, Yuto; Kanda, Yasunari; Kreir, Mohamed; Levesque, Paul; Miyamoto, Norimasa; Pierson, Jennifer B.; Shafer, Timothy J.; Schachtele, Scott; Strock, Christopher J.; Yoshinaga, Takashi; Suzuki, Ikuro
Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment

通过整合覆盖神经发育关键细胞事件的新方法方法（NAMs）组合数据，对发育神经毒性化学物质进行优先排序

Neurotoxicology
IF3.9
2026-07-010
OAAI
Hall, Laura A.; Hsieh, Jui-Hua; Marvel, Skylar W.; Behl, Mamta; Fritsche, Ellen; Koch, Katharina; Kreutz, Anna; Leist, Marcel; Muriana, Arantza; Shafer, Timothy J.; Stanko, Jason P.; Sills, Robert C.; Hogberg, Helena T.; McPherson, Christopher A.
Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds

应用高密度微电极阵列检测技术，采用3D人诱导多能干细胞（iPSC）衍生的脑微生理系统模型，进行环境化合物的体外神经毒性筛选。

ARCHIVES OF TOXICOLOGY
IF6.9
2025-04-280
OA
Carstens, Kelly E.; Gronskaya, Elena; Jaeckel, David; Bertoli, Jessica; Cuevas, Kelvin Ramirez; Dorier, Julien; Wang, Shan; Lopez-Rodriguez, David; Shafer, Timothy J.; Zurich, Marie-Gabrielle; Pamies, David
Integration of new approach methods for the assessment of data-poor chemicals

整合评估数据贫乏化学品的新方法

TOXICOLOGICAL SCIENCES
IF4.1
2025-02-190
PRE
Friedman, Katie Paul; Thomas, Russell S.; Wambaugh, John F.; Harrill, Joshua A.; Judson, Richard S.; Shafer, Timothy J.; Williams, Antony J.; Lee, Jia-Ying Joey; Loo, Lit-Hsin; Gagne, Matthew; Long, Alexandra S.; Barton-Maclaren, Tara S.; Whelan, Maurice; Bouhifd, Mounir; Rasenberg, Mike; Simanainen, Ulla; Sobanski, Tomasz
Mapping Out Strategies to Further Develop Human-Relevant New Approach Methodology (NAM)- Based Developmental Neurotoxicity (DNT) Testing

制定进一步发展基于人类相关性新方法学(NAM)的发育神经毒性(DNT)测试的策略

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
IF5.8
2025-01-012
OA
Cöllen, E; Bartmann, K; Blum, J; Carstens, K; Celardo, I; Chatterjee, N; Corvaro, M; Dreser, N; Fritsche, E; Hartung, T; Hogberg, HT; Knudsen, T; Koch, K; Kreutz, A; Lislien, M; Magel, V; Marty, MS; Pallocca, G; Bal-Price, A; Rovida, C; Sachana, M; Shafer, TJ; Smirnova, L; Suciu, I; Tanaskov, Y; Tangianu, S; Wolfbeisz, C; Leist, M
Developmental Neurotoxicity (DNT): A Call for Implementation of New Approach Methodologies for Regulatory Purposes: Summary of the 5th International Conference on DNT Testing

发育神经毒性（DNT）：呼吁实施新的方法学以用于监管目的：第5届国际发育神经毒性测试会议总结

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
IF5.8
2025-01-012
OA
Celardo, I; Aschner, M; Ashton, RS; Carstens, KE; Cediel-Ulloa, A; Cöllen, E; Crofton, KM; Debad, SJ; Dreser, N; Fitzpatrick, S; Fritsche, E; Gutsfeld, S; Hardy, B; Hartung, T; Hessel, E; Heusinkveld, H; Hogberg, HT; Hsieh, JH; Kanda, Y; Knight, GT; Knudsen, T; Koch, K; Kuchovska, E; Mangas, I; Marty, MS; Melching-Kollmuss, S; Müller, I; Müller, P; Myhre, O; Paparella, M; Pitzer, E; Bal-Price, A; Sachana, M; Schlüppmann, K; Shafer, TJ; Schäfer, J; Smirnova, L; Tal, T; Tanaskov, Y; Tangianu, S; Testa, G; Ückert, AK; Whelan, M; Leist, M

研究方向

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