张吉泉 (Jiquan Zhang)

Guizhou Medical University

H指数:18

被引数:1,312

个人简介

张吉泉，理学博士，教授，博士生/硕士生导师，国家自然科学基金通讯评审专家。2015年毕业于中山大学药学院，目前担任药物化学系主任及贵州省化学合成药物研发利用工程技术研究中心副主任，入选贵州省优秀青年科技人才及贵州医科大学青年领军人才计划。近年主持国家自然科学基金（3项）、贵州省科技重大专项子课题、贵州省自然科学基金重点项目及贵州省科技支撑计划等项目10余项。以第一作者及通讯作者在Acta Pharm Sin B、J Me...等期刊发表论文。

教育背景

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工作经历

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荣誉奖项

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Design, synthesis, and anti-colorectal cancer activity of quinoxalines with improved drug-like properties

含改进药物特性的喹喔啉的设计、合成及其抗结直肠癌活性

Bioorganic Chemistry

IF4.7

2026-05-050

PRE

The impact of illness perception on quality of life in lung cancer chemotherapy patients: mediating effect of fear of progression

疾病感知对肺癌化疗患者生活质量的影响：进展恐惧的调节作用

Frontiers in Psychiatry

IF3.2

2025-11-240

OAAI

Computation-driven discovery of novel chromone derivatives for the treatment of triple-negative breast cancer via mTOR-targeted inhibition and triggering antitumor immunity

基于计算驱动的靶向mTOR抑制和触发抗肿瘤免疫的新型色酮衍生物的发现，用于三阴性乳腺癌的治疗

Acta Pharmaceutica Sinica B

IF14.6

2025-09-120

OAAI

Association between Advanced Lung Cancer Inflammation Index and 30-day mortality in patients with spontaneous intracerebral hemorrhage: a retrospective cohort study

高级肺癌炎症指数与自发性脑出血患者30天死亡率的相关性：一项回顾性队列研究

Frontiers in Neurology

IF2.8

2025-08-170

The novel diarylurea derivative HPT-15 for potential treatment of triple-negative breast cancer via dual inhibition of the mTOR and MAPK pathways

新型双芳基脲衍生物HPT-15可通过同时抑制mTOR和MAPK通路，用于潜在治疗三阴性乳腺癌。

Cellular Signalling

IF3.7

2025-06-090

PRE

A σ-π bond interchange assisted σ-π cross-metathesis reaction for nonoxidative conversion of methyl ketones to carboxylic acids

一种由σ-π键交换辅助的σ-π交叉复分解反应，用于甲基酮的非氧化转化生成羧酸

Chinese Chemical Letters

IF8.9

2025-04-300

PRE

Discovery of highly potent mTOR inhibitors aimed at suppressing the progression of acute myeloid leukemia

发现高活性mTOR抑制剂，旨在抑制急性髓系白血病的进展

BIOORGANIC CHEMISTRY

IF4.7

2025-04-010

PRE

DKS26 Alleviates Ischemia-Reperfusion Injury-Induced Acute Kidney Injury by Stabilizing Vitamin D Receptors to Inhibit the Inflammatory Pathway of NF-κB P65

DKS26通过稳定维生素D受体以抑制NF-κB P65炎症通路，缓解缺血再灌注损伤诱导的急性肾损伤。

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-03-250

The impact of depression on the quality of life of lung cancer patients undergoing chemotherapy: mediating effects of perceived social support

抑郁症对接受化疗的肺癌患者生活质量的影响：感知社会支持的调节效应

FRONTIERS IN PSYCHIATRY

IF3.2

2025-03-211

Nickel-Catalyzed Rearranged Alkenylation of 2-Arylaziridines with Aryl Alkenes to Access Allylamines

ORGANIC LETTERS

IF5

2025-03-010

PRE

The impact of work-family conflict on occupational fatigue among endoscopy nurses in China: a moderated mediation model

FRONTIERS IN PUBLIC HEALTH

IF3.4

2024-10-231

OAAI

Redox-Neutral Coupling of Allyl Alcohols with Trifluoromethyl Ketones via Synergistic Ni-Ti Bimetallic Catalysis

ORGANIC LETTERS

IF5

2024-08-260

PRE

Carbene-Catalyzed [4+2] Cycloaddition of Cyclobutenones and Isatins for Quick Access to Chiral Chlorine-Containing Spirocyclic δ-Lactones

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-05-020

PRE

MMSyn: A New Multimodal Deep Learning Framework for Enhanced Prediction of Synergistic Drug Combinations

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2024-04-271

PRE

Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-04-252

PRE

The impact of social support for older adults in nursing homes on successful aging: a moderated mediation model

养老院老年人社会支持对成功老龄化的影响: 一个有调节的中介模型

FRONTIERS IN PUBLIC HEALTH

IF3.4

2024-02-212

OAAI

Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-11-014

PRE

Lipid-Based Nanocarriers Enabled Oral Delivery of Oleanolic Acid Derivative DKS26 for Diabetes Management

ADVANCED HEALTHCARE MATERIALS

IF9.6

2023-04-255

PRE

Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-1264

PRE

DBU-Catalyzed Aerobic CDC Reaction of Thiophenols

DBU催化苯硫酚的好氧CDC反应

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2022-12-067

PRE

研究方向

近年主持的代表性科研项目基于 mTOR/HDAC 双重抑制的抗三阴乳腺癌药物分子的设计、合成及生物活性评价EGFR/PI3Kα双靶点抑制剂设计与合成生物活性评价基于嘧啶与三嗪母核的PI3Kα/mTOR双靶点抑制剂的设计、合成及生物活性研究PARP-PI3Kα双靶点抑制剂设计合成抗卵巢癌活性与机制研究基于获得性耐药的嘧啶类EGFR/PI3Kα双靶点抑制剂的设计、合成及抗肿瘤活性研究靶向抗肿瘤药物研究Zhang, J.-Q.*Zhang, N.Ran, Y.Yu, Q.-Y.Lu, J.Chen, R.Zhang, S.Dong, Y.Wang, R.-H.Yang, Y.Li, Y.Liao, W.Wang, L.*Zhan, C.*色酮衍生物三阴性乳腺癌mTOR抑制抗肿瘤免疫Meng, T.Zhong, H.Pan, W.Zhang, J.*He, H.*可控靶向蛋白降解Sun, Q.Chu, Y.Wang, L.Wu, J.Li, H.Tang, L.*三取代三嗪的设计、合成与生物评价mTOR抑制剂乳腺癌治疗Zhang, J.-Q.Luo, Y.-J.Xiong, Y.-S.Yu, Y.Tu, Z.-C.Long, Z.-J.Lai, X.-J.Chen, H.-X.Luo, Y.Weng, J.PI3K抑制剂药物化学Wang, Y.Wu, H.Luo, J.Zhu, J.Chen, Z.Chai, Y. e.Wang, J.Liu, G. Xu, J.*Ma, Y.*二芳基脲衍生物HPT-15mTOR/MAPK双抑制Han, Q.Wang, X.Ma, Y.Jin, Z.Huang, J.Chai, Y.*Li, H.*Discovery of highly potent mTOR inhibitorsWang, T.Chen, J.Ouyang, Z.Ouyang, W.Hu, C.EGFR-PI3Kα抑制剂非小细胞肺癌治疗Pang, Y.Chen, Y.Lin, M.Zhang, Y.多模态深度学习协同药物组合预测Ban, Y.Pan, F.Guo, Z.Wei, X.Li, G.Qian, J.脂质纳米载体口服递送齐墩果酸衍生物糖尿病管理Zheng, X.-M.Chen, Y.-S.Ban, Y.-J.Wang, Y.-J.Dong, Y.-X.Lei, L.Guo, B.Wang, J.-T.Li, H.-L.*Zhang, N.-N.