Philip F. Hughes - Publications, H-index & Citations

Philip F. Hughes

eydis bio inc.

32H指数

131论文数

3.3K被引数

收录论文 46

发表时间

Pharmacological inhibition of transforming growth factor-β activated kinase 1 (TAK1) prevents chemotherapy induced peripheral neuropathy (CIPN)药理学抑制转化生长因子-β激活激酶1（TAK1）可预防化疗诱导的周围神经病变（CIPN）。

the journal of pain

IF0

2026-03-31

OAAI

Timothy Haystead; Denise Giuvelis; Robert Freeze; Philip Hughes; Tamara King; Scott Scarneo

TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

CELL DEATH & DISEASE

IF9.6

2024-04-17

OAAI

Damhofer, Helene; Tatar, Tulin; Southgate, Benjamin; Scarneo, Scott; Agger, Karl; Shlyueva, Daria; Uhrbom, Lene; Morrison, Gillian M.; Hughes, Philip F.; Haystead, Timothy; Pollard, Steven M.; Helin, Kristian

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome

CELL CHEMICAL BIOLOGY

IF7.2

2024-04-01

OAAI

Mansfield, Christopher R.; Quan, Baiyi; Chirgwin, Michael E.; Eduful, Benjamin; Hughes, Philip F.; Neveu, Gaeurolle; Sylvester, Kayla; Ryan, Daniel H.; Kafsack, Bjorn F. C.; Haystead, Timothy A. J.; Leahy, James W.; Fitzgerald, Michael C.; Derbyshire, Emily R.

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

CELL CHEMICAL BIOLOGY

IF7.2

2024-03-01

OAAI

Carlson, Dave L.; Kowalewski, Mark; Bodoor, Khaldon; Lietzan, Adam D.; Hughes, Philip F.; Gooden, David; Loiselle, David R.; Alcorta, David; Dingman, Zoey; Mueller, Elizabeth A.; Irnov, Irnov; Modla, Shannon; Chaya, Tim; Caplan, Jeffrey; Embers, Monica; Miller, Jennifer C.; Jacobs-Wagner, Christine; Redinbo, Matthew R.; Spector, Neil; Haystead, Timothy A. J.

Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein

SCIENTIFIC REPORTS

IF3.9

2023-12-18

OAAI

Haystead, Timothy; Lee, Eric; Cho, Kirstin; Gullickson, Gail; Hughes, Philip; Krafsur, Greta; Freeze, Robert; Scarneo, Scott

Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis

JCI INSIGHT

IF6.1

2023-07-24

OAAI

Bale, Swarna; Verma, Priyanka; Yalavarthi, Bharath; Scarneo, Scott Arthur; Hughes, Philip; Amin, M. Asif; Tsou, Pei-Suen; Khanna, Dinesh; Haystead, Timothy A. J.; Bhattacharyya, Swati; Varga, John

Targeting the TAK1/TNF signaling pathway with novel pharmacological inhibitors

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-06-01

OAAI

Scarneo, Scott; Haystead, Timothy; Hughes, Philip; Freeze, Robert

Expression of membrane Hsp90 is a molecular signature of T cell activation

SCIENTIFIC REPORTS

IF3.9

2022-10-27

OAAI

Scarneo, Scott A.; Smith, Aaron P.; Favret, Jacob; O'Connell, Robert; Pickeral, Joy; Yang, Kelly W.; Ferrari, Guido; Loiselle, David R.; Hughes, Philip F.; Kulkarni, Manjusha M.; Gargesha, Madhusudhana; Scott, Bryan; Roy, Debashish; Haynes, Barton F.; Kwiek, Jesse J.; Haystead, Timothy A. J.

Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis 用于治疗炎症性关节炎的口服生物利用度选择性TAK1抑制剂的开发和功效

ACS CHEMICAL BIOLOGY

IF3.8

2022-03-02

OAAI

Scarneo, Scott; Hughes, Philip; Freeze, Robert; Yang, Kelly; Totzke, Juliane; Haystead, Timothy

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

MOLECULAR CANCER THERAPEUTICS

IF5.5

2021-10-21

OAAI

Osada, Takuya; Crosby, Erika J.; Kaneko, Kensuke; Snyder, Joshua C.; Ginzel, Joshua D.; Acharya, Chaitanya R.; Yang, Xiao-Yi; Polascik, Thomas J.; Spasojevic, Ivan; Nelson, Rendon C.; Hobeika, Amy; Hartman, Zachary C.; Neckers, Leonard M.; Rogatko, Andre; Hughes, Philip F.; Huang, Jiaoti; Morse, Michael A.; Haystead, Timothy; Lyerly, H. Kim

Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain

PAIN

IF5.5

2021-10-12

OAAI

Wang, Yaomin; Scarneo, Scott A.; Kim, Shin Hyung; Zhang, Xin; Chen, Jiegen; Yang, Kelly W.; Hughes, Philip; Haystead, Timothy; Nackley, Andrea G.

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2020-12-16

OAAI

Dong, Bushu; Jaeger, Alex M.; Hughes, Philip F.; Loiselle, David R.; Hauck, J. Spencer; Fu, Yao; Haystead, Timothy A.; Huang, Jiaoti; Thiele, Dennis J.

Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors

COMMUNICATIONS BIOLOGY

IF5.1

2020-05-08

OAAI

Kaneko, Kensuke; Osada, Takuya; Morse, Michael A.; Gwin, William R.; Ginzel, Joshua D.; Snyder, Joshua C.; Yang, Xiao-Yi; Liu, Cong-Xiao; Diniz, Marcio A.; Bodoor, Khaldon; Hughes, Philip F.; Haystead, Timothy A. J.; Lyerly, H. Kim

A highly selective inhibitor of interleukin-1 receptor?associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-02-01

OAAI

Scarneo, Scott A.; Hughes, Philip F.; Yang, Kelly W.; Carlson, David A.; Gurbani, Deepak; Westover, Kenneth D.; Haystead, Timothy A. J.

Application of immobilized ATP to the study of NLRP inflammasomes

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

IF3

2019-07-01

PREAI

Liao, Kuo-Chieh; Sandall, Christina F.; Carlson, David A.; Ulke-Lemee, Annegret; Platnich, Jaye M.; Hughes, Philip F.; Muruve, Daniel A.; Haystead, Timothy A. J.; MacDonald, Justin A.

A novel heat shock protein 90 targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Kaneko, Kensuke; Osada, Takuya; Hughes, Philip F.; Haystead, Timothy A.; Morse, Michael A.; Lyerly, Herbert K.

Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer

SCIENTIFIC REPORTS

IF3.9

2019-03-05

OAAI

Crouch, Brian T.; Gallagher, Jennifer; Wang, Roujia; Duer, Joy; Hall, Allison; Soo, Mary Scott; Hughes, Philip; Haystead, Timothy; Ramanujam, Nirmala

Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites

CELL CHEMICAL BIOLOGY

IF7.2

2019-03-01

OAAI

Raphemot, Rene; Eubanks, Amber Leigh; Toro-Moreno, Maria; Geiger, Rechel Anne; Hughes, Philip Floyd; Lu, Kuan-Yi; Haystead, Timothy Arthur James; Derbyshire, Emily Rose

Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

SCIENTIFIC REPORTS

IF3.9

2018-11-19

OAAI

Scarneo, Scott A.; Mansourati, Antoine; Eibschutz, Lies S.; Totzke, Juliane; Rogues, Jose R.; Loiselle, David; Carlson, David; Hughes, Philip; Haystead, Timothy A. J.

Targeting Pim Kinases and DAPK3 to Control Hypertension

CELL CHEMICAL BIOLOGY

IF7.2

2018-10-01

OAAI

Carlson, David A.; Singer, Miriam R.; Sutherland, Cindy; Redondo, Clara; Alexander, Leila T.; Hughes, Philip F.; Knapp, Stefan; Gurley, Susan B.; Sparks, Matthew A.; MacDonald, Justin A.; Haystead, Timothy A. J.

研究方向