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R

Robert J. Hickey

Howard Hughes Medical Institute

36H指数
163论文数
4.2K被引数
收录论文 50
发表时间
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Targeting Cancer-Associated PCNA with AOH1996 Induces Mitotic Catastrophe and Enhances Cisplatin Therapy in Cervical Cancer靶向癌症相关PCNA的AOH1996诱导有丝分裂灾难并增强顺铂疗法在宫颈癌中的应用
errCancer Research Communications
IF0
err2026-05-01
err0
PREAI
errWendel, Sebastian O.; Brooke, Grant M.; Hu, Changkun; Sandoval, Allison R.; Haratipour, Pouya; Gu, Long; Young, Malaney; Zangi, Maryam; Rasche, Brittany L.; Banerjee, N. s.; Jossart, Jennifer; Garvin, Kelly; Geisbrecht, Brian V.; Cianciolo, Rachel; Cawley, Jacob; Perry, J. Jefferson P.; Hickey, Robert J.; Malkas, Linda H.; Wallace, Nicholas A.
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Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112筛选靶向PCNA的新型化学骨架，鉴定出Hsp90alpha抑制剂SNX-2112
errCurrent Research in Structural Biology
IF2.5
err2026-02-11
err0
errOAAI
errJennifer Jossart; Ning Ma; Pouya Haratipour; Caroline M. Li; Christopher Jang; Long Gu; Terrence E. O'Brien; Nagarajan Vaidehi; Linda H. Malkas; Robert J. Hickey; J. Jefferson P. Perry
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AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition (vol 13, 123, 2024)AOH1996通过抑制线粒体PCNA，靶向作用于白血病干细胞中的线粒体动力学和代谢（vol 13, 123, 2024）
errhematology oncology
IF13.5
err2025-04-10
err0
errOAAI
errKang, HyunJun; Valerio, Melissa; Feng, Jia; Gu, Long; Hoang, Dinh Hoa; Blackmon, Amanda; Sharkas, Shawn; Pathak, Khyatiben; Jossart, Jennifer; Li, Zhuo; Zhang, Hongyu; Zhang, Bin; Pirrotte, Patrick; Perry, J. Jefferson P.; Hickey, Robert J.; Malkas, Linda; Marcucci, Guido
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Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma靶向癌基因诱导的转录-复制冲突在胰导管腺癌中的治疗应用
errGastroenterology
IF25.1
err2025-04-08
err0
errOAAI
errShanna J. Smith; Fan Meng; Robert G. Lingeman; Caroline M. Li; Min Li; Galyah Boneh; Toni T. Seppälä; Thuy Phan; Haiqing Li; Richard A. Burkhart; Vishwas Parekh; Syed Rahmanuddin; Laleh G. Melstrom; Robert J. Hickey; Vincent Chung; Yilun Liu; Linda H. Malkas; Mustafa Raoof
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AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibitionAOH1996通过抑制线粒体PCNA靶向白血病干细胞的线粒体动力学和代谢
errhematology oncology
IF13.5
err2024-12-28
err0
errOAAI
errKang, Hyunjun; Valerio, Melissa; Feng, Jia; Gu, Long; Hoang, Dinh Hoa; Blackmon, Amanda; Sharkas, Shawn; Pathak, Khyatiben; Jossart, Jennifer; Li, Zhuo; Zhang, Hongyu; Zhang, Bin; Pirrotte, Patrick; Perry, J. Jefferson P.; Hickey, Robert J.; Malkas, Linda; Marcucci, Guido; Nguyen, Le Xuan Truong
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err收藏
Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errGu, Long; Li, Ming; Chen, Chun-Wei; Hickey, Robert J.; Malkas, Linda H.
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Enhanced lung cancer treatment using AOH1996, a potent PCNA inhibitor
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errLingeman, Robert G.; Hickey, Robert J.; Malkas, Linda H.
err分享
err收藏
From proteomic analysis to early investigations of combining inhibitors targeting PCNA and histone deacetylase
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errLi, Caroline M.; Garcia-Mansfield, Krystine; Lingeman, Robert G.; Gu, Long; Hickey, Robert J.; Pirrotte, Patrick; Malkas, Linda H.
err分享
err收藏
Developing a selective cancer chemotherapy by small molecule-based targeting of PCNA protein
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errJossart, Jennifer; Gu, Long; Haratipour, Pouya; Li, Caroline; Lingeman, Robert; Hickey, Robert; Malkas, Linda; Perry, John J.
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err收藏
Structure-based drug design against caPCNA for selective cancer chemotherapy development
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errJossart, Jennifer; Haratipour, Pouya; Gu, Long; Li, Carone M.; Lingeman, Robert; Liu, Yilun; Hickey, Robert J.; Malkas, Linda H.; Perry, Jeff J.
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err收藏
Enhancing AOH1996 through structure activity relationship exploration for caPCNA inhibition
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errHaratipour, Pouya; Zangi, Maryam; Yaghoubi, Mahshid; Gu, Long; Jossart, Jennifer; Perry, John J.; Malkas, Linda H.; Hickey, Robert J.
err分享
err收藏
Small molecule targeting of transcription-replication conflict for selective chemotherapy选择性化疗的转录-复制冲突小分子靶向研究
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-10-01
err19
errOAAI
errGu, Long; Li, Min; Li, Caroline M.; Haratipour, Pouya; Lingeman, Robert; Jossart, Jennifer; Gutova, Margarita; Flores, Linda; Hyde, Caitlyn; Kenjic, Nikola; Li, Haiqing; Chung, Vincent; Li, Hongzhi; Lomenick, Brett; Von Hoff, Daniel D.; Synold, Timothy W.; Aboody, Karen S.; Liu, Yilun; Horne, David; Hickey, Robert J.; Perry, J. Jefferson P.; Malkas, Linda H.
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Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff通过复制径流将核糖体DNA前导链上的拓扑异构酶1裂解复合物转化为5 ′-磷酸化DNA双链断裂
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err332
errOAAI
errStrumberg, D; Pilon, AA; Smith, M; Hickey, R; Malkas, L; Pommier, Y
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err收藏
Novel Peptide Therapeutic Approaches for Cancer Treatment
errCELLS
IF5.2
err2021-10-27
err83
errOAAI
errLi, Caroline M.; Haratipour, Pouya; Lingeman, Robert G.; Perry, J. Jefferson P.; Gu, Long; Hickey, Robert J.; Malkas, Linda H.
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Molecular Targeting of Cancer-Associated PCNA Interactions in Pancreatic Ductal Adenocarcinoma Using a Cell-Penetrating Peptide
errMOLECULAR THERAPY ONCOLYTICS
IF5.3
err2020-06-01
err20
errOAAI
errSmith, Shanna J.; Li, Caroline M.; Lingeman, Robert G.; Hickey, Robert J.; Liu, Yilun; Malkas, Linda H.; Raoof, Mustafa
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err收藏
Mechanistic study of the superior anti-cancer properties of a first in-class small molecule targeting PCNA
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2019-12-01
err1
PREAI
errGu, Long; Li, Min; Lingeman, Robert; Hickey, Robert J.; Liu, Yilun; Malkas, Linda H.
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err收藏
Biomarkers of response to deslorelin in women at high risk of breast cancer
errCANCER RESEARCH
IF16.6
err2018-07-01
err0
PREAI
errWeitzel, Jeffrey N.; Press, Michael F.; Sand, Sharon R.; Zhang, Lei; Klifa, Catherine; Pike, Malcolm; Ursin, Giske; Spicer, Darcy V.; Daniels, AnnaMarie; Herzog, Josef; Miao, Yunan; Wuenschell, Gerald; Li, Chun; Hickey, Robert
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How Does the Proliferating Cell Nuclear Antigen Modulate Binding Specificity to Multiple Partner Proteins?
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2017-11-17
err6
PREAI
errLi, Hubert; Sandhu, Manbir; Malkas, Linda H.; Hickey, Robert J.; Vaidehi, Nagarajan
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Targeting SMC1 in combination therapy for triple negative breast cancer
errCANCER RESEARCH
IF16.6
err2016-07-15
err0
PREAI
errYadav, Sushma; Berz, David; Somlo, George; Ashing, Kimlin; Yuan, Yate-Ching; Hickey, Robert J.; Yadav, Sailee; Riggs, Arthur D.
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Validating the disruption of proliferating cell nuclear antigen interactions in the development of targeted cancer therapeutics在靶向癌症治疗的发展中验证增殖细胞核抗原相互作用的破坏
errCANCER BIOLOGY & THERAPY
IF4.6
err2016-02-18
err7
errOAAI
errSmith, Shanna J.; Hickey, Robert J.; Malkas, Linda H.
err分享
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研究方向

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