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N

Nicolas H. Thomä

Friedrich Miescher Institute for Biomedical Research
H指数:49
被引数:1.1万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Proteome-wide identification of the druggable CRBN interactome

全蛋白质组范围可成药性CRBN相互作用组的鉴定

Nature Biotechnology
IF41.7
2026-08-130
OA
Pius Galli; Shuhao Xiao; Yanxiang Meng; Alexander Hanzl; Alexandra M. Bendel; Regina Baur; Jacob D. Aguirre; Anna M. Diaz-Rovira; Maximilian R. Stammnitz; Georg Kempf; Lukas Kater; Kenji Shimada; Ye Wei; Andreas Scheck; Dominique Klein; Simone Cavadini; Ben Lehner; Guillaume Diss; Bruno E. Correia; Nicolas H. Thomä
The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2

人类BAF染色质重塑因子处理由先锋转录因子OCT4–SOX2结合的核小体

Molecular Cell
IF16.6
2026-02-110
OAAI
Joscha Weiss; Luca Vecchia; David Domjan; Simone Cavadini; Anton Sabantsev; Georg Kempf; Ganesh R. Pathare; Klaus Brackmann; Alicia K. Michael; Lukas Kater; Eric Hietter-Pfeiffer; Mina Haddawi; Urja P. Kuber; Sandra Mühlhäusser; Ralph S. Grand; Michael B. Stadler; Sebastian Deindl; Nicolas H. Thomä
Nucleosomes specify co-factor access to p53

核小体规定了辅因子对p53的访问

Molecular Cell
IF16.6
2025-07-250
PRE
Deyasini Chakraborty; Colby R. Sandate; Luke Isbel; Georg Kempf; Joscha Weiss; Simone Cavadini; Lukas Kater; Jan Seebacher; Zuzanna Kozicka; Lisa Stoos; Ralph S. Grand; Dirk Schübeler; Alicia K. Michael; Nicolas H. Thomä
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance (vol 15, 275, 2024)
NATURE COMMUNICATIONS
IF15.7
2024-08-190
OAAI
Schroeder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R.
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
NATURE COMMUNICATIONS
IF15.7
2024-01-0421
OA
Schroder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R.
Design principles for cyclin K molecular glue degraders
NATURE CHEMICAL BIOLOGY
IF13.7
2023-09-0718
OAAI
Kozicka, Zuzanna; Suchyta, Dakota J.; Focht, Vivian; Kempf, Georg; Petzold, Georg; Jentzsch, Marius; Zou, Charles; Di Genua, Cristina; Donovan, Katherine A.; Coomar, Seemon; Cigler, Marko; Mayor-Ruiz, Cristina; Schmid-Burgk, Jonathan L.; Haeussinger, Daniel; Winter, Georg E.; Fischer, Eric S.; Slabicki, Mikolaj; Gillingham, Dennis; Ebert, Benjamin L.; Thomae, Nicolas H.
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
MOLECULAR CELL
IF16.6
2023-08-0121
OAAI
Tsai, Jonathan M.; Aguirre, Jacob D.; Li, Yen-Der; Brown, Jared; Focht, Vivian; Kater, Lukas; Kempf, Georg; Sandoval, Brittany; Schmitt, Stefan; Rutter, Justine C.; Galli, Pius; Sandate, Colby R.; Cutler, Jevon A.; Zou, Charles; Donovan, Katherine A.; Lumpkin, Ryan J.; Cavadini, Simone; Park, Paul M. C.; Sievers, Quinlan; Hatton, Charlie; Ener, Elizabeth; Regalado, Brandon D.; Sperling, Micah T.; Sabicki, Mikoaj; Kim, Jeonghyeon; Zon, Rebecca; Zhang, Zinan; Miller, Peter G.; Belizaire, Roger; Sperling, Adam S.; Fischer, Eric S.; Irizarry, Rafael; Armstrong, Scott A.; Thoma, Nicolas H.; Ebert, Benjamin L.
Cooperation between bHLH transcription factors and histones for DNA access
Nature
IF48.5
2023-07-050
OAAI
Alicia K. Michael; Lisa Stoos; Priya Crosby; Nikolas Eggers; Xinyu Y. Nie; Kristina Makasheva; Martina Minnich; Kelly L. Healy; Joscha Weiss; Georg Kempf; Simone Cavadini; Lukas Kater; Jan Seebacher; Luca Vecchia; Deyasini Chakraborty; Luke Isbel; Ralph S. Grand; Florian Andersch; Jennifer L. Fribourgh; Dirk Schübeler; Johannes Zuber; Andrew C. Liu; Peter B. Becker; Beat Fierz; Carrie L. Partch; Jerome S. Menet; Nicolas H. Thomä

研究方向

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S
Simone Cavadini
H 指数:29论文数:67被引数:4,298
G
Georg Petzold
H 指数:19论文数:34被引数:3,795
Z
Zuzanna Kozicka
H 指数:9论文数:26被引数:1,607
E
Eric S. Fischer
H 指数:55论文数:281被引数:1.4万
B
Benjamin L. Ebert
H 指数:122论文数:775被引数:15.5万
G
Georg Kempf
H 指数:19论文数:67被引数:1,518
J
Joscha Weiss
H 指数:5论文数:14被引数:697
R
R.D. Bunker
H 指数:19论文数:73被引数:3,377
M
Mikołaj Słabicki
H 指数:33论文数:97被引数:4,872
D
Dirk Schübeler
H 指数:83论文数:168被引数:2.9万