Brian C. Monk - Publications, H-index & Citations

Brian C. Monk

University of Otago

44H指数

171论文数

6.5K被引数

收录论文 41

发表时间

The dual role of azoles: lifesaving antifungals and drivers of resistance – a One Health perspective 唑类的双重作用: 挽救生命的抗真菌药和耐药性的驱动因素-一个健康的观点

Nature Communications

IF15.7

2026-04-19

OAAI

Behrad Roohi; Joel D. A. Tyndall; Thomas Svoboda; Sybren de Hoog; Pedro W. Crous; Brian C. Monk; Birgit Strobl; Annemarie Weissenbacher; Joseph Strauss; Paul E. Verweij; Michaela Lackner

Intrinsic resistance to short-tailed azoles in the basal fungus Mucor lusitanicus: functional analysis of Cyp51 isoforms and amino acid substitutions 米根霉(Mucor lusitanicus)中短尾唑类药物的内源性耐药性：Cyp51异构体的功能分析及氨基酸替换分析

Frontiers in Microbiology

IF4.5

2025-11-27

OAAI

K. Rosam; M. V. Keniya; L.-M. Zenz; C. Müller; B. Sarg; M. Stojanovic; U. Binder; B. C. Monk; M. Lackner

Exploring Long Arm Amide-Linked Side Chains in the Design of Antifungal Azole Inhibitors of Sterol 14α-Demethylase (CYP51)探索长臂酰胺连接侧链在甾醇14α-去甲基酶（CYP51）抗真菌唑类抑制剂设计中的应用

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-05-22

OAAI

Alsulaimany, Marwa; Keniya, Mikhail V.; Alanazi, Rehab S.; Ruma, Yasmeen N.; Hughes, Carwyn S.; Jones, Arwyn T.; Tyndall, Joel D. A.; Parker, Josie E.; Monk, Brian C.; Simons, Claire

Exploring medium and long arm extensions of 1,2,4-triazole derivatives as Candida albicans 14α-demethylase (CYP51) inhibitors

RSC MEDICINAL CHEMISTRY

IF3.6

2025-03-01

OAAI

Alsulaimany, Marwa; Binjubair, Faizah A.; Tatar, Esra; Kelly, Diane E.; Kelly, Steven L.; Warrilow, Andrew G.; Keniya, Mikhail V.; Monk, Brian C.; Parker, Josie E.; Simons, Claire

Synthesis and antifungal evaluation of novel triazole derivatives bearing a pyrazole-methoxyl moiety

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-09-01

PREAI

Hao, Yumeng; Wang, Ruina; Ni, Tingjunhong; Monk, Brian C.; Tyndall, Joel D. A.; Bao, Junhe; Wang, Mengyuan; Chi, Xiaochen; Yu, Shichong; Jin, Yongsheng; Zhang, Dazhi; Yan, Lan; Xie, Fei

Novel antifungal triazoles with alkynyl-methoxyl side chains: Design, synthesis, and biological activity evaluation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-09-01

PREAI

Xie, Fei; Hao, Yumeng; Li, Liping; Wang, Ruina; Bao, Junhe; Chi, Xiaochen; Monk, Brian C.; Wang, Ting; Yu, Shichong; Jin, Yongsheng; Zhang, Dazhi; Ni, Tingjunhong; Yan, Lan

Highlighting membrane protein structure and function: A celebration of the Protein Data Bank

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Li, Fei; Egea, Pascal F.; Vecchio, Alex J.; Asial, Ignacio; Gupta, Meghna; Paulino, Joana; Bajaj, Ruchika; Dickinson, Miles Sasha; Ferguson-Miller, Shelagh; Monk, Brian C.; Stroud, Robert M.

Emergency Department Factors Associated With Early Rapid Responses Activation After Admission

ANNALS OF EMERGENCY MEDICINE

IF5

2019-10-01

PREAI

Silvas, K.; O'Neill, J.; Monk, B.; Schorr, R.; Kamaleswaran, R.

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2019-01-01

OAAI

Monk, Brian C.; Keniya, Mikhail V.; Sabherwal, Manya; Wilson, Rajni K.; Graham, Danyon O.; Hassan, Harith F.; Chen, Danni; Tyndall, Joel D. A.

Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-11-01

102

OAAI

Keniya, Mikhail, V; Sabherwal, Manya; Wilson, Rajni K.; Woods, Matthew A.; Sagatova, Alia A.; Tyndall, Joel D. A.; Monk, Brian C.

Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-11-01

OAAI

Keniya, Mikhail, V; Ruma, Yasmeen N.; Tyndall, Joel D. A.; Monka, Brian C.

Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-03-01

OAAI

Sagatova, Alia A.; Keniya, Mikhail V.; Tyndall, Joel D. A.; Monk, Brian C.

Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase

SCIENTIFIC REPORTS

IF3.9

2017-11-21

OAAI

Caramalho, Rita; Tyndall, Joel D. A.; Monk, Brian C.; Larentis, Thomas; Lass-Floerl, Cornelia; Lackner, Michaela

Targeting efflux pumps to overcome antifungal drug resistance

FUTURE MEDICINAL CHEMISTRY

IF3.4

2016-07-27

107

OAAI

Holmes, Ann R.; Cardno, Tony S.; Strouse, J. Jacob; Ivnitski-Steele, Irena; Keniya, Mikhail V.; Lackovic, Kurt; Monk, Brian C.; Sklar, Larry A.; Cannon, Richard D.

Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric (vol 6, 27132, 2016)

SCIENTIFIC REPORTS

IF3.9

2016-07-25

OAAI

Rawal, Manpreet Kaur; Banerjee, Atanu; Shah, Abdul Haseeb; Khan, Mohammad Firoz; Sen, Sobhan; Saxena, Ajay Kumar; Monk, Brian C.; Cannon, Richard D.; Bhatnagar, Rakesh; Mondal, Alok Kumar; Prasad, Rajendra

Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

SCIENTIFIC REPORTS

IF3.9

2016-06-02

OAAI

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

SCIENTIFIC REPORTS

IF3.9

2016-05-18

OAAI

Sagatova, Alia A.; Keniya, Mikhail V.; Wilson, Rajni K.; Sabherwal, Manya; Tyndall, Joel D. A.; Monk, Brian C.

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2015-08-01

160

OAAI

Sagatova, Alia A.; Keniya, Mikhail V.; Wilson, Rajni K.; Monk, Brian C.; Tyndall, Joel D. A.

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-02-03

248

OAAI

Monk, Brian C.; Tomasiak, Thomas M.; Keniya, Mikhail V.; Huschmann, Franziska U.; Tyndall, Joel D. A.; O'Connell, Joseph D., III; Cannon, Richard D.; McDonald, Jeffrey G.; Rodriguez, Andrew; Finer-Moore, Janet S.; Stroud, Robert M.

TRANSPORTERS A yeast ABC interactome primer

NATURE CHEMICAL BIOLOGY

IF13.7

2013-08-19

PREAI

Monk, Brian C.

研究方向