未登录 Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement 探索3CL蛋白酶抑制剂中的P1残基,导致发现2-四氢呋喃P1置换 Barton, Linda S.; Callahan, James F.; Cantizani, Juan; Concha, Nestor O.; Torrejon, Ignacio Cotillo; Goodwin, Nicole C.; Joshi-Pangu, Amruta; Kiesow, Terry J.; McAtee, Jeff J.; Mellinger, Mark; Nixon, Christopher J.; Padron-Barthe, Laura; Patterson, Jaclyn R.; Pearson, Neil D.; Pouliot, Jeffrey J.; Rendina, Alan R.; Santanilla, Alexander Buitrago; Schneck, Jessica L.; Sanz, Olalla; Thalji, Reema K.; Ward, Paris; Williams, Shawn P.; King, Bryan W. 分享 收藏
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Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor Chong, Pek Y.; Shotwell, J. Brad; Miller, John; Price, Daniel J.; Maynard, Andy; Voitenleitner, Christian; Mathis, Amanda; Williams, Shawn; Pouliot, Jeffrey J.; Creech, Katrina; Wang, Feng; Fang, Jing; Zhang, Huichang; Tai, Vincent W. -F.; Turner, Elizabeth; Kahler, Kirsten M.; Crosby, Renae; Peat, Andrew J. 分享 收藏
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A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site Hardwicke, Mary Ann; Rendina, Alan R.; Williams, Shawn P.; Moore, Michael L.; Wang, Liping; Krueger, Julie A.; Plant, Ramona N.; Totoritis, Rachel D.; Zhang, Guofeng; Briand, Jacques; Burkhart, William A.; Brown, Kristin K.; Parrish, Cynthia A. 分享 收藏
Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase Maynard, Andrew; Crosby, Renae M.; Ellis, Byron; Hamatake, Robert; Hong, Zhi; Johns, Brian A.; Kahler, Kirsten M.; Koble, Cecilia; Leivers, Anna; Leivers, Martin R.; Mathis, Amanda; Peat, Andrew J.; Pouliot, Jeffrey J.; Roberts, Christopher D.; Samano, Vicente; Schmidt, Rachel M.; Smith, Gary K.; Spaltenstein, Andrew; Stewart, Eugene L.; Thommes, Pia; Turner, Elizabeth M.; Voitenleitner, Christian; Walker, Jill T.; Waitt, Greg; Weatherhead, Jason; Weaver, Kurt; Williams, Shawn; Wright, Lois; Xiong, Zhiping Z.; Haigh, David; Shotwell, J. Brad 分享 收藏
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Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2) Whitby, Richard J.; Stec, Jozef; Blind, Raymond D.; Dixon, Sally; Leesnitzer, Lisa M.; Orband-Miller, Lisa A.; Williams, Shawn P.; Willson, Timothy M.; Xu, Robert; Zuercher, William J.; Cai, Fang; Ingraham, Holly A. 分享 收藏
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Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction Phelan, Caroline A.; Gampe, Robert T., Jr.; Lambert, Millard H.; Parks, Derek J.; Montana, Valerie; Bynum, Jane; Broderick, Timothy M.; Hu, Xiao; Williams, Shawn P.; Nolte, Robert T.; Lazar, Mitchell A. 分享 收藏
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Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor Biggadike, Keith; Bledsoe, Randy K.; Coe, Diane M.; Cooper, Tony W. J.; House, David; Iannone, Marie A.; Macdonald, Simon J. F.; Madauss, Kevin P.; McLay, Iain M.; Shipley, Tracy J.; Taylor, Simon J.; Tran, Thuy B.; Uings, Iain J.; Weller, Victoria; Williams, Shawn P. 分享 收藏
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Structure-guided design of N-phenyl tertiary Amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity Chao, Esther Y.; Caravella, Justin A.; Watson, Mike A.; Campobasso, Nino; Ghisletti, Serena; Billin, Andrew N.; Galardi, Cristin; Wang, Ping; Laffitte, Bryan A.; Lannone, Marie A.; Goodwin, Bryan J.; Nichols, Jason A.; Parks, Derek J.; Stewart, Eugene; Wiethe, Robert W.; Williams, Shawn P.; Smallwood, Angela; Pearce, Kenneth H.; Glass, Christopher K.; Willson, Timothy M.; Zuercher, William J.; Collins, Jon L. 分享 收藏
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A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor Bledsoe, RK; Madauss, KP; Holt, JA; Apolito, CJ; Lambert, MH; Pearce, KH; Stanley, TB; Stewart, EL; Trump, RP; Willson, TM; Williams, SP 分享 收藏
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