未登录 Fragment-Based Design of Pseudo-Natural Products, Synthesis, and Evaluation of Their HIV-1 Latency-Reversing Properties 基于片段的伪天然产物设计、合成及其逆转HIV-1潜伏期特性的评估 Tanyi, Solange A.; Eni, Donatus B.; Abdelsalam, Mohamed; Tjegbe, Mathieu J. M.; Schmidt, Matthias; Ndip, Roland N.; Tietjen, Ian; Sippl, Wolfgang; Ntie-Kang, Fidele 分享 收藏
Traditional uses and pharmacological activities of Tetracera alnifolia wild Tetracera alnifolia野生的传统用途和药理活性 Camara, A. K.; Balde, E. S.; Diallo, M. S. T.; Camara, M. K.; Bah, T. V.; Conde, M.; Soumah, A.; Kamano, K.; Tietjen, I.; Balde, A. M. 分享 收藏
Ex vivo and in vivo HIV-1 latency reversal by Mukungulu, a protein kinase C-activating African medicinal plant extract 离体和体内HIV-1潜伏期逆转由Mukungulu（一种蛋白激酶C激活剂非洲药用植物提取物）实现 Richard, Khumoekae; Yuan, Zhe; Tang, Hsin-Yao; Goldman, Aaron R.; Kuthu, Riza; Raphane, Boingotlo; Register, Emery T.; Sharma, Paridhima; Ross, Brian N.; Morris, Jessicamarie; Williams, David E.; Cheney, Carol; Wu, Guoxin; Mounzer, Karam; Laird, Gregory M.; Zuck, Paul; Andersen, Raymond J.; Simonambango, Sundana; Andrae-Marobela, Kerstin; Tietjen, Ian; Montaner, Luis J. 分享 收藏
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis 对spirooxindoles作为SARS-CoV-2刺突蛋白/ACE2相互作用阻断剂的评估：合成、生物评价和计算分析 Ehinak, Albert Enama; Lobe, Maloba M. M.; Eni, Donatus B.; Simoben, Conrad V.; Tietjen, Ian; Tjegbe, Mathieu J. Mbenga; Cassel, Joel; Salvino, Joseph M.; Montaner, Luis J.; Efange, Simon M. N. 分享 收藏
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Design of novel and highly selective SARS-CoV-2 main protease inhibitors 新型高选择性SARS-CoV-2主要蛋白酶抑制剂的设计 Poli, Adi N. R.; Tietjen, Ian; Nandwana, Nitesh K.; Cassel, Joel; Messick, Troy E.; Register, Emery T.; Keeney, Frederick; Rajaiah, Rajesh; Verma, Atul K.; Pandey, Kabita; Acharya, Arpan; Byrareddy, Siddappa N.; Montaner, Luis J.; Salvino, Joseph M. 分享 收藏
Metabolomic Analysis and Antiviral Screening of a Marine Algae Library Yield Jobosic Acid (2,5-Dimethyltetradecanoic Acid) as a Selective Inhibitor of SARS-CoV-2 Matos-Hernandez, Marie L.; Samples, Robert; Dyer, Grayce; Montan, Victoria M. Casimir; Morales-Colon, Chris A.; Salvino, Joseph M.; Montaner, Luis J.; Cassel, Joel A.; Messick, Troy E.; Tietjen, Ian; Caro-Diaz, Eduardo J. E. 分享 收藏
Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety EvaluationS 二价金属转运蛋白1的有效肠道限制性抑制剂: 抗铁过载的临床前疗效和安全性评估 Cutts, Alison; Chowdhury, Sultan; Ratkay, Laszlo G.; Eyers, Maryanne; Young, Clint; Namdari, Rostam; Cadieux, Jay A.; Chahal, Navjot; Grimwood, Michael; Zhang, Zaihui; Lin, Sophia; Tietjen, Ian; Xie, Zhiwei; Robinette, Lee; Sojo, Luis; Waldbrook, Matthew; Hayden, Michael; Mansour, Tarek; Pimstone, Simon; Goldberg, Y. Paul; Webb, Michael; Cohen, Charles J. 分享 收藏
Synthetic Analogs of the Sponge Sesterterpenoid Alotaketal C are Potent Inhibitors of SARS-CoV-2 Omicron BA.1 and BA.5 Infections of Human Lung Cells Blagojevic, Polina; Perez-Vargas, Jimena; Jian, Kunzhong; Williams, David E.; Villanueva, Ivan; Thompson, Connor A. H.; Ennis, Siobhan; Niikura, Masahiro; Tietjen, Ian; Jean, Francois; Andersen, Raymond J. 分享 收藏
The Natural Stilbenoid (-)-Hopeaphenol Inhibits HIV Transcription by Targeting Both PKC and NF-κB Signaling and Cyclin-Dependent Kinase 9 Tietjen, Ian; Schonhofer, Cole; Sciorillo, Amanda; Naidu, Maya E.; Haq, Zahra; Kannan, Toshitha; Kossenkov, Andrew V.; Rivera-Ortiz, Jocelyn; Mounzer, Karam; Hart, Colin; Gyampoh, Kwasi; Yuan, Zhe; Beattie, Karren D.; Rali, Topul; McGuire, Kristy Shuda; Davis, Rohan A.; Montaner, Luis J. 分享 收藏
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Thorectidiol A Isolated from the Marine Sponge Dactylospongia elegans Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor Williams, David E.; Cassel, Joel; Zhu, Jin-Lin; Yang, Jian-Xiong; de Voogd, Nicole J.; Matainaho, Teatulohi; Salvino, Joseph M.; Wang, Yan Alexander; Montaner, Luis J.; Tietjen, Ian; Andersen, Raymond J. 分享 收藏
HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant Gnidia sericocephala (Thymelaeaceae) Tembeni, Babalwa; Sciorillo, Amanda; Invernizzi, Luke; Klimkait, Thomas; Urda, Lorena; Moyo, Phanankosi; Naidoo-Maharaj, Dashnie; Levitties, Nathan; Gyampoh, Kwasi; Zu, Guorui; Yuan, Zhe; Mounzer, Karam; Nkabinde, Siphathimandla; Nkabinde, Magugu; Gqaleni, Nceba; Tietjen, Ian; Montaner, Luis J.; Maharaj, Vinesh 分享 收藏
Ansellone J, a Potent in Vitro and ex Vivo HIV-1 Latency Reversal Agent Isolated from a Phorbas sp. Marine Sponge Wang, Meng; Sciorillo, Amanda; Read, Silven; Divsalar, Donya Naz; Gyampoh, Kwasi; Zu, Guorui; Yuan, Zhe; Mounzer, Karam; Williams, David E.; Montaner, Luis J.; de Voogd, Nicole; Tietjen, Ian; Andersen, Raymond J. 分享 收藏
Use of hyphenated analytical techniques to identify the bioactive constituents of Gunnera perpensa L., a South African medicinal plant, which potently inhibit SARS-CoV-2 spike glycoprotein-host ACE2 binding Invernizzi, Luke; Moyo, Phanankosi; Cassel, Joel; Isaacs, Freddie J.; Salvino, Joseph M.; Montaner, Luis J.; Tietjen, Ian; Maharaj, Vinesh 分享 收藏
The Natural Stilbenoid (-)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants Tietjen, Ian; Cassel, Joel; Register, Emery T.; Zhou, Xiang Yang; Messick, Troy E.; Keeney, Frederick; Lu, Lily D.; Beattie, Karren D.; Rali, Topul; Tebas, Pablo; Ertl, Hildegund C. J.; Salvino, Joseph M.; Davis, Rohan A.; Montaner, Luis J. 分享 收藏
Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold Zhang, Chen; Lum, Kah Yean; Taki, Aya C.; Gasser, Robin B.; Byrne, Joseph J.; Wang, Tao; Blaskovich, Mark A. T.; Register, Emery T.; Montaner, Luis J.; Tietjen, Ian; Davis, Rohan A. 分享 收藏
Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency Schonhofer, Cole; Yi, Jennifer; Sciorillo, Amanda; Andrae-Marobela, Kerstin; Cochrane, Alan; Harris, Marianne; Brumme, Zabrina L.; Brockman, Mark A.; Mounzer, Karam; Hart, Colin; Gyampoh, Kwasi; Yuan, Zhe; Montaner, Luis J.; Tietjen, Ian 分享 收藏
The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal Richard, Khumoekae; Schonhofer, Cole; Giron, Leila B.; Rivera-Ortiz, Jocelyn; Read, Silven; Kannan, Toshitha; Kinloch, Natalie N.; Shahid, Aniqa; Feilcke, Ruth; Wappler, Simone; Imming, Peter; Harris, Marianne; Brumme, Zabrina L.; Brockman, Mark A.; Mounzer, Karam; Kossenkov, Andrew V.; Abdel-Mohsen, Mohamed; Andrae-Marobela, Kerstin; Montaner, Luis J.; Tietjen, Ian 分享 收藏
Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus Duncan, Maggie C.; Onguene, Pascal Amoa; Kihara, Ibuki; Nebangwa, Derrick N.; Naidu, Maya E.; Williams, David E.; Balgi, Aruna D.; Andrae-Marobela, Kerstin; Roberge, Michel; Andersen, Raymond J.; Niikura, Masahiro; Ntie-Kang, Fidele; Tietjen, Ian 分享 收藏
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