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É

Éric Leclerc

university of tokyo

34H指数
205论文数
4.1K被引数
收录论文 69
发表时间
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Proteomic analysis reveals a metabolic switch and cellular remodelling in pancreatic-like cell spheroids cocultured with hepatocyte-like cells using an interconnected liver-pancreas-on-chip system蛋白质组学分析揭示使用互连的肝-胰腺芯片系统共培养的类胰腺细胞球与类肝细胞共培养中的代谢转换和细胞重塑
errMolecular Omics
IF2.4
err2026-08-26
err0
PREAI
errAmal Essaouiba; Jérôme Vicogne; Alexandre Stella; Mathieu Danoy; Anne Gonzalez de Peredo; Cécile Legallais; Yasuyuki Sakai; Rachid Jellali; Eric Leclerc
err分享
err收藏
A Computational Model of Inflammation Reveals Crosstalk among Energy Metabolism, Oxidative Stress, Insulin, and Cytokines in Hepatocytes during Early MASLD Progression
errToxicological Sciences
IF4.1
err2025-12-17
err0
PREAI
errYuki Miura; Yasuyuki Sakai; Masaki Nishikawa; Eric Leclerc
err分享
err收藏
Palmitic acid induced the onset of lipotoxicity in a HepaSH-on-chip model with raised of H2O2 and IL-6, and altered p38/MAPK & JAK/STAT pathways棕榈酸在HepaSH-on-chip模型中诱导了脂毒性，伴随H2O2和IL-6水平升高，并改变了p38/MAPK和JAK/STAT通路。
errToxicology
IF4.6
err2025-11-22
err0
PREAI
errHanyuan Wang; Stéphane Poulain; Wenxin Cao; Hiroshi Arakawa; Soo Hyeon Kim; Yukio Kato; Masaki Nishikawa; Yasuyuki Sakai; Eric Leclerc
err分享
err收藏
Identification of the differential and synergic lipotoxic patterns of oleic acid, palmitic acid, and their mixture in 3D HepG2/C3A tissue using liver-on-chip technology使用肝芯片技术识别油酸、棕榈酸及其混合物在3D HepG2/C3A组织中差异性和协同性的脂毒性模式
errBiotechnology Progress
IF2.5
err2025-10-13
err0
PREAI
errLisa Morisseau; Valérie Pawlowski; Valérie Plaisance; Mathilde Lucas; Cécile Legallais; Yasuyuki Sakai; Amar Abderrahmani; Rachid Jellali; Eric Leclerc
err分享
err收藏
In situ formation and culture of cell spheroids in a low-binding 3D-printed biochip低结合3D打印生物芯片中原位形成和培养细胞微球
errLab Chip
IF0
err2025-10-08
err0
PREAI
errAlexandre Martins; Sylvie Klieber; Charlotte Le Graët; Eric Leclerc; Cécile Legallais; Rachid Jellali
err分享
err收藏
Computational modeling of the hepatocytes reveals new insights into alterations in drug metabolism, oxidative stress response, and glutathione detoxification in acetaminophen-induced hepatotoxicity associated with MASLD肝细胞计算建模揭示了关于与MASLD相关的对乙酰氨基酚诱导肝毒性中药物代谢、氧化应激反应和谷胱甘肽解毒变化的新的见解。
errComputational Toxicology
IF2.9
err2025-09-27
err0
PREAI
errYuki Miura; Yasuyuki Sakai; Masaki Nishikawa; Eric Leclerc
err分享
err收藏
3D hepatic spheroids and liver-organ on chip models displayed maintenance of hepatic functions and maturation profile in a long-term culture of the humanized HepaSH cells, a human cell population harvested from chimeric mice3D肝细胞球体和肝器官芯片模型显示，在长期培养的人类化HepaSH细胞（一种从嵌合小鼠中获取的人类细胞群）中，保持了肝功能维持和成熟表型。
errBiotechnology Progress
IF2.5
err2025-05-31
err0
PREAI
errHanyuan Wang; Carla Meschini; Stéphane Poulain; Soo Hyeon Kim; Hiroshi Arakawa; Yukio Kato; Cecile Legallais; Ulysse Pereira; Yasuyuki Sakai; Eric Leclerc
err分享
err收藏
Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver- and pancreas-on-chip coculture人诱导多能干细胞衍生的肝脏-和胰腺-芯片共培养的转录组学表征及其协同作用
errMolecular and Cellular Endocrinology
IF3.6
err2025-05-21
err0
PREAI
errAmal Essaouiba; Rachid Jellali; Stéphane Poulain; Soo Hyeon Kim; Mathieu Danoy; Cécile Legallais; Yasuyuki Sakai; Eric Leclerc
err分享
err收藏
A computational model of the crosstalk between hepatocyte fatty acid metabolism and oxidative stress highlights the key enzymes, metabolites, and detoxification pathways in the context of MASLD
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2025-02-01
err0
PREAI
errMiura, Yuki; Voican, Cosmin; Sakai, Yasuyuki; Nishikawa, Masaki; Leclerc, Eric
err分享
err收藏
Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro
errBIOFABRICATION
IF8
err2024-03-25
err0
PREAI
errScheidecker, Benedikt; Poulain, Stephane; Sugimoto, Masahiro; Kido, Taketomo; Kawanishi, Takumi; Miyajima, Atsushi; Kim, Soo Hyeon; Arakawa, Hiroshi; Kato, Yukio; Nishikawa, Masaki; Danoy, Mathieu; Sakai, Yasuyuki; Leclerc, Eric
err分享
err收藏
Investigation of the motif activity of transcription regulators in pancreatic β-like cell subpopulations differentiated from human induced pluripotent stem cells
errMOLECULAR OMICS
IF2.4
err2024-01-01
err0
PREAI
errLeclerc, Eric; Pachkov, Mikhail; Morisseau, Lisa; Tokito, Fumiya; Legallais, Cecile; Jellali, Rachid; Nishikawa, Masaki; Abderrahmani, Amar; Sakai, Yasuyuki
err分享
err收藏
Investigation of the metabolomic crosstalk between liver sinusoidal endothelial cells and hepatocytes exposed to paracetamol using organ-on-chip technology使用器官芯片技术研究肝窦内皮细胞与暴露于扑热息痛的肝细胞之间的代谢组串扰
errTOXICOLOGY
IF4.6
err2023-06-01
err3
errOAAI
errMesselmani, Taha; Le Goff, Anne; Soncin, Fabrice; Gilard, Francoise; Souguir, Zied; Maubon, Nathalie; Gakiere, Bertrand; Legallais, Cecile; Leclerc, Eric; Jellali, Rachid
err分享
err收藏
Transcriptomic and proteomic studies suggest the establishment of advanced zonation-like profiles in human-induced pluripotent stem cell-derived liver sinusoidal endothelial cells and carboxypeptidase M-positive liver progenitor cells cocultured in a fluidic microenvironment
errHEPATOLOGY RESEARCH
IF3.4
err2023-04-02
err2
PREAI
errDanoy, Mathieu; Poulain, Stephane; Jellali, Rachid; Scheidecker, Benedikt; Tauran, Yannick; Leduc, Marjorie; Bruce, Johanna; Kim, Soo Hyeon; Kido, Taketomo; Miyajima, Atsushi; Sakai, Yasuyuki; Leclerc, Eric
err分享
err收藏
Generation of β-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids
errMOLECULAR OMICS
IF2.4
err2023-01-01
err2
errOAAI
errMorisseau, Lisa; Tokito, Fumiya; Poulain, Stephane; Plaisance, Valerie; Pawlowski, Valerie; Kim, Soo Hyeon; Legallais, Cecile; Jellali, Rachid; Sakai, Yasuyuki; Abderrahmani, Amar; Leclerc, Eric
err分享
err收藏
Investigation of the Exometabolomic Profiles of Rat Islets of Langerhans Cultured in Microfluidic Biochip
errMETABOLITES
IF3.7
err2022-12-15
err3
errOAAI
errEssaouiba, Amal; Jellali, Rachid; Gilard, Francoise; Gakiere, Bertrand; Okitsu, Teru; Legallais, Cecile; Sakai, Yasuyuki; Leclerc, Eric
err分享
err收藏
Development of Liver-on-Chip Integrating a Hydroscaffold Mimicking the Liver's Extracellular Matrix
errBIOENGINEERING-BASEL
IF3.7
err2022-09-05
err11
errOAAI
errMesselmani, Taha; Le Goff, Anne; Souguir, Zied; Maes, Victoria; Roudaut, Meryl; Vandenhaute, Elodie; Maubon, Nathalie; Legallais, Cecile; Leclerc, Eric; Jellali, Rachid
err分享
err收藏
Liver organ-on-chip models for toxicity studies and risk assessment
errLAB ON A CHIP
IF5.4
err2022-01-01
err46
errOAAI
errMesselmani, Taha; Morisseau, Lisa; Sakai, Yasuyuki; Legallais, Cecile; Le Goff, Anne; Leclerc, Eric; Jellali, Rachid
err分享
err收藏
Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip
errMOLECULAR OMICS
IF2.4
err2022-01-01
err3
errOAAI
errEssaouiba, Amal; Jellali, Rachid; Poulain, Stephane; Tokito, Fumiya; Gilard, Francoise; Gakiere, Bertrand; Kim, Soo Hyeon; Legallais, Cecile; Sakai, Yasuyuki; Leclerc, Eric
err分享
err收藏
Investigation of steatosis profiles induced by pesticides using liver organ-on-chip model and omics analysis
errFOOD AND CHEMICAL TOXICOLOGY
IF3.5
err2021-06-01
err20
errOAAI
errJellali, Rachid; Jacques, Sebastien; Essaouiba, Amal; Gilard, Francoise; Letourneur, Franck; Gakiere, Bertrand; Legallais, Cecile; Leclerc, Eric
err分享
err收藏
Investigation of the hepatic development in the coculture of hiPSCs-derived LSECs and HLCs in a fluidic microenvironment
errAPL BIOENGINEERING
IF4.1
err2021-05-10
err12
errOAAI
errDanoy, Mathieu; Tauran, Yannick; Poulain, Stephane; Jellali, Rachid; Bruce, Johanna; Leduc, Marjorie; Le Gall, Morgane; Koui, Yuta; Arakawa, Hiroshi; Gilard, Francoise; Gakiere, Bertrand; Kato, Yukio; Plessy, Charles; Kido, Taketomo; Miyajima, Atsushi; Sakai, Yasuyuki; Leclerc, Eric
err分享
err收藏

研究方向

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合作学者
合作期刊
A
Atsushi Miyajima
H 指数: 93 · 论文数: 462
H
Hiroyuki Kusuhara
H 指数: 84 · 论文数: 456
P
Pierre Layrolle
H 指数: 75 · 论文数: 264
M
Marc‐Emmanuel Dumas
H 指数: 62 · 论文数: 341
F
Frédéric Y. Bois
H 指数: 53 · 论文数: 366
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