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Structural basis for partial agonism in 5-HT3A receptors (jan, 10.1038/s41594-023-01140-2, 2024) Felt, Kevin; Stauffer, Madeleine; Salas-Estrada, Leslie; Guzzo, Peter R.; Xie, Dejian; Huang, Jinkun; Filizola, Marta; Chakrapani, Sudha 分享 收藏
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CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome Roberts, Alexander; Grafton, Gillian; Powell, Andrew D.; Brock, Kristian; Chen, Chunlin; Xie, Dejian; Huang, Jinkun; Liu, Shuang; Cooper, Alison J.; Brady, Catherine A.; Qureshi, Omar; Stamataki, Zania; Manning, David D.; Moore, Nicholas A.; Sargent, Bruce J.; Guzzo, Peter R.; Barnes, Nicholas M. 分享 收藏
Bifidenone: Structure - Activity Relationship and Advanced Preclinical Candidate Huang, Zhongping; Williams, Russell B.; Martin, Steven M.; Lawrence, Julie A.; Norman, Vanessa L.; O'Neil-Johnson, Mark; Harding, Jim; Mangette, John E.; Liu, Shuang; Guzzo, Peter R.; Starks, Courtney M.; Eldridge, Gary R. 分享 收藏
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1 Cioffi, Christopher L.; Liu, Shuang; Wolf, Mark A.; Guzzo, Peter R.; Sadalapure, Kashinath; Parthasarathy, Visweswaran; Loong, David T. J.; Maeng, Jun-Ho; Carulli, Edmund; Fang, Xiao; Karunakaran, Kalesh; Matta, Lakshman; Choo, Sok Hui; Panduga, Shailijia; Buckle, Ronald N.; Davis, Randall N.; Sakwa, Samuel A.; Gupta, Priya; Sargent, Bruce J.; Moore, Nicholas A.; Luche, Michele M.; Carr, Grant J.; Khmelnitsky, Yuri L.; Ismail, Jiffry; Chung, Mark; Bai, Mei; Leong, Wei Yee; Sachdev, Nidhi; Swaminathan, Srividya; Mhyre, Andrew J. 分享 收藏
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties Guo, Cheng; Hu, Min; DeOrazio, Russell J.; Usyatinsky, Alexander; Fitzpatrick, Kevin; Zhang, Zhenjun; Maeng, Jun-Ho; Kitchen, Douglas B.; Tom, Susan; Luche, Michele; Khmelnitsky, Yuri; Mhyre, Andrew J.; Guzzo, Peter R.; Liu, Shuang 分享 收藏
Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors Liu, Shuang; Zha, Congxiang; Nacro, Kassoum; Hu, Min; Cui, Wenge; Yang, Yuh-Lin; Bhatt, Ulhas; Sambandam, Aruna; Isherwood, Matthew; Yet, Larry; Herr, Michael T.; Ebeltoft, Sarah; Hassler, Carla; Fleming, Linda; Pechulis, Anthony D.; Payen-Fornicola, Anne; Holman, Nicholas; Milanowski, Dennis; Cotterill, Ian; Mozhaev, Vadim; Khmelnitsky, Yuri; Guzzo, Peter R.; Sargent, Bruce J.; Molino, Bruce F.; Olson, Richard; King, Dalton; Lelas, Snjezana; Li, Yu-Wen; Johnson, Kim; Molski, Thaddeus; One, Anitra; Ng, Alicia; Haskell, Roy; Clarke, Wendy; Bertekap, Robert; O'Connell, Jonathan; Lodge, Nicholas; Sinz, Michael; Adams, Stephen; Zaczek, Robert; Macor, John E. 分享 收藏
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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity Sebhat, Iyassu K.; Franklin, Christopher; Lo, Michael M. -C.; Chen, David; Jewell, James P.; Miller, Randy; Pang, Jianmei; Palyha, Oksana; Kan, Yanqing; Kelly, Theresa M.; Guan, Xiao-Ming; Marsh, Donald J.; Kosinski, Jennifer A.; Metzger, Joseph M.; Lyons, Kathryn; Dragovic, Jasminka; Guzzo, Peter R.; Henderson, Alan J.; Reitman, Marc L.; Nargund, Ravi P.; Wyvratt, Matthew J.; Lin, Linus S. 分享 收藏
ALB-109564, a novel tubulin inhibitor with improved efficacy over vinorelbine, is better tolerated when dosed iv versus ip, leading to improved activity in human tumor xenograft studies Wolf, Mark A.; Johnson, Randall K.; Xie, Deijian; Avrutskaya, Anna; Mullin, Robert; Godfrey, Beverly; Mead, Mary Ann; Trachet, Erin E.; Leopold, Wilbur R.; Guzzo, Peter; Scott, Ian 分享 收藏
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Effects of (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice Lehmann, A; Holmberg, AA; Bhatt, U; Bremner-Danielsen, M; Brändén, L; Elg, S; Elebring, T; Fitzpatrick, K; Geiss, WB; Guzzo, P; Jensen, J; Jerndal, G; Mattsson, JP; Nilsson, K; Olsson, BM 分享 收藏
Synthesis and pharmacological evaluation of novel γ-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors Alstermark, Christer; Amin, Kosrat; Dinn, Sean R.; Elebring, Thomas; Fjellstroem, Ola; Fitzpatrick, Kevin; Geiss, William B.; Gottfries, Johan; Guzzo, Peter R.; Harding, James P.; Holmen, Anders; Kothare, Mohit; Lehmann, Anders; Mattsson, P.; Nilsson, Karolina; Sunden, Gunnel; Swanson, Marianne; von Unge, Sverker; Woo, Alex M.; Wyle, Michael J.; Zheng, Xiaozhang 分享 收藏
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Novel cyclopropyl β-amino acid analogues of pregabalin and gabapentin that target the α2-δ protein Schwarz, JB; Gibbons, SE; Graham, SR; Colbry, NL; Guzzo, PR; Le, VD; Vartanian, MG; Kinsora, JJ; Lotarski, SM; Li, Z; Dickerson, MR; Su, TZ; Weber, ML; El-Kattan, A; Thorpe, AJ; Donevan, SD; Taylor, CP; Wustrow, DJ 分享 收藏
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