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N

Nyssa Drinkwater

monash university

H指数:20

被引数:911

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Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

IF0

2024-07-080

OA

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

IF4.7

2024-06-120

OAAI

Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1′-region optimisation

通过S1 ′ 区优化有效的恶性疟原虫M1和M17氨肽酶选择性和双重抑制剂的基于结构的开发

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-02-014

PRE

A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-07-013

OAAI

Research Article Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

BIOCHEMICAL JOURNAL

IF4.3

2021-07-1613

OAAI

Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-0111

OAAI

A Structure-Activity Relationship Study of Novel Hydroxamic Acid Inhibitors around the S1 Subsite of Human Aminopeptidase N

IF3.4

2020-10-221

PREAI

X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2

BIOCHEMICAL JOURNAL

IF4.3

2020-10-123

OAAI

M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment

M17氨肽酶通过调节其大分子组装和活性位点环境来实现功能多样化

IF3

2019-11-0125

PREAI

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-06-2817

PREAI

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

IF3.4

2019-02-138

OAAI

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-12-1126

PREAI

X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2017-03-032

OAAI

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

IF4.2

2017-02-0358

OAAI

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

BIOCHEMICAL JOURNAL

IF4.3

2016-09-2715

OAAI

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2016-03-0147

OAAI

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

SCIENTIFIC REPORTS

IF3.9

2015-05-1229

OAAI

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2015-02-2814

PREAI

Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-10-2452

OAAI

From crystal to compound: structure-based antimalarial drug discovery

BIOCHEMICAL JOURNAL

IF4.3

2014-07-1018

PREAI