Ruth Brenk - Publications, H-index & Citations

Ruth Brenk

University of Dundee

30H指数

124论文数

3.5K被引数

收录论文 40

发表时间

Discovery of RNA-binding fragments using Biolayer Interferometry 使用生物层干涉法发现RNA结合片段

RSC Med. Chem.

IF3.6

2025-09-27

OAAI

Vipul Panchal; Jan-Åke Husmann; Kaja Günther; Muhammad Zeeshan; Bengt Erik Haug; Ruth Brenk

Towards new antibiotics: P. aeruginosa FabF ligands discovered by crystallographic fragment screening followed by hit expansion 走向新型抗生素：通过晶体学片段筛选及后续命中扩展发现P. aeruginosa FabF配体

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-07-01

PREAI

Georgiou, Charis; Espeland, Ludvik Olai; Bukya, Hemalatha; Yadrykhins'ky, Vladyslav; Haug, Bengt Erik; Mainkar, Prathama S.; Brenk, Ruth

Assessing small molecule conformational sampling methods in molecular docking

JOURNAL OF COMPUTATIONAL CHEMISTRY

IF4.8

2024-10-30

OAAI

Xia, Qiancheng; Fu, Qiuyu; Shen, Cheng; Brenk, Ruth; Huang, Niu

Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2024-01-26

OAAI

Gartan, Parveen; Khorsand, Fahimeh; Mizar, Pushpak; Vahokovski, Juha Ilmari; Cervantes, Luis F.; Haug, Bengt Erik; Brenk, Ruth; Brooks III, Charles L.; Reuter, Nathalie

Introduction to the themed collection on 'Targeting RNA with small molecules'

RSC MEDICINAL CHEMISTRY

IF3.6

2024-01-01

PREAI

Brenk, Ruth; Wu, Peng; Duca, Maria

Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

RSC MEDICINAL CHEMISTRY

IF3.6

2024-01-01

OAAI

Jalencas, Xavier; Berg, Hannes; Espeland, Ludvik Olai; Sreeramulu, Sridhar; Kinnen, Franziska; Richter, Christian; Georgiou, Charis; Yadrykhinsky, Vladyslav; Specker, Edgar; Jaudzems, Kristaps; Miletic, Tanja; Harmel, Robert; Gribbon, Phil; Schwalbe, Harald; Brenk, Ruth; Jirgensons, Aigars; Zaliani, Andrea; Mestres, Jordi

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

COMMUNICATIONS CHEMISTRY

IF6.2

2022-12-07

OAAI

Bothe, Sebastian; Haenzelmann, Petra; Boehler, Stephan; Kehrein, Josef; Zehe, Markus; Wiedemann, Christoph; Hellmich, Ute A.; Brenk, Ruth; Schindelin, Hermann; Sotriffer, Christoph

Fragment-Based Drug Discovery for RNA Targets

CHEMMEDCHEM

IF3.4

2021-08-10

OAAI

Lundquist, Kasper P.; Panchal, Vipul; Gotfredsen, Charlotte H.; Brenk, Ruth; Clausen, Mads H.

An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics

CHEMMEDCHEM

IF3.4

2021-08-06

OAAI

Espeland, Ludvik Olai; Georgiou, Charis; Klein, Raphael; Bhukya, Hemalatha; Haug, Bengt Erik; Underhaug, Jarl; Mainkar, Prathama S.; Brenk, Ruth

DrugPred_RNA-A Tool for Structure-Based Druggability Predictions for RNA Binding Sites 基于结构的RNA结合位点药力预测的DrugPred_RNA-A工具

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2021-07-21

OAAI

Rekand, Illimar Hugo; Brenk, Ruth

Riboswitches as Drug Targets for Antibiotics

ANTIBIOTICS-BASEL

IF4.6

2021-01-05

OAAI

Panchal, Vipul; Brenk, Ruth

How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-08-19

OAAI

Kersten, Christian; Fleischer, Edmond; Kehrein, Josef; Borek, Christoph; Jaenicke, Elmar; Sotriffer, Christoph; Brenk, Ruth

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-09-12

OAAI

Harrison, Justin R.; Brand, Stephen; Smith, Victoria; Robinson, David A.; Thompson, Stephen; Smith, Alasdair; Davies, Kenneth; Mok, Ngai; Torrie, Leah S.; Collie, Iain; Hallyburton, Irene; Norval, Suzanne; Simeons, Frederick R. C.; Stojanovski, Laste; Frearson, Julie A.; Brenk, Ruth; Wyatt, Paul G.; Gilbert, Ian H.; Read, Kevin D.

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-11-22

OAAI

Bayliss, Tracy; Robinson, David A.; Smith, Victoria C.; Brand, Stephen; McElroy, Stuart P.; Torrie, Leah S.; Mpamhanga, Chido; Norval, Suzanne; Stojanovski, Laste; Brenk, Ruth; Frearson, Julie K.; Read, Kevin D.; Gilbert, Ian H.; Wyatt, Paul G.

Ligand design for riboswitches, an emerging target class for novel antibiotics

FUTURE MEDICINAL CHEMISTRY

IF3.4

2017-09-19

PREAI

Rekand, Illimar Hugo; Brenk, Ruth

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

CHEMMEDCHEM

IF3.4

2015-09-23

OAAI

Spinks, Daniel; Smith, Victoria; Thompson, Stephen; Robinson, David A.; Luksch, Torsten; Smith, Alasdair; Torrie, Leah S.; McElroy, Stuart; Stojanovski, Laste; Norval, Suzanne; Collie, Iain T.; Hallyburton, Irene; Rao, Bhavya; Brand, Stephen; Brenk, Ruth; Frearson, Julie A.; Read, Kevin D.; Wyatt, Paul G.; Gilbert, Ian H.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-11-20

OAAI

Brand, Stephen; Norcross, Neil R.; Thompson, Stephen; Harrison, Justin R.; Smith, Victoria C.; Robinson, David A.; Torrie, Leah S.; McElroy, Stuart P.; Hallyburton, Irene; Norval, Suzanne; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick R. C.; van Aalten, Daan; Frearson, Julie A.; Brenk, Ruth; Fairlamb, Alan H.; Ferguson, Michael A. J.; Wyatt, Paul G.; Gilbert, Ian H.; Read, Kevin D.

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-09-08

OAAI

Urich, Robert; Grimaldi, Raffaella; Luksch, Torsten; Frearson, Julie A.; Brenk, Ruth; Wyatt, Paul G.

Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2014-01-09

OAAI

Mok, N. Yi; Brenk, Ruth; Brown, Nathan

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules 从靶向到脱靶活性: 鉴定和优化布氏锥虫GSK3抑制剂及其作为抗布氏锥虫药物发现先导分子的特征

CHEMMEDCHEM

IF3.4

2013-06-14

OAAI

Woodland, Andrew; Grimaldi, Raffaella; Luksch, Torsten; Cleghorn, Laura A. T.; Ojo, Kayode K.; Van Voorhis, Wesley C.; Brenk, Ruth; Frearson, Julie A.; Gilbert, Ian H.; Wyatt, Paul G.

研究方向