John D. Hayes - Publications, H-index & Citations

John D. Hayes

university of dundee

92H指数

356论文数

4.6W被引数

收录论文 112

发表时间

The CNC-bZIP transcription factor Nrf2 controls expression of matrix metalloproteases in murine macrophages CNC-bZIP转录因子Nrf2调控小鼠巨噬细胞中基质金属蛋白酶的表达

Journal of Leukocyte Biology

IF3.1

2026-03-04

OAAI

Abel D Ang; Sharadha Dayalan Naidu; Oliver J Read; Pingting Bian; Aileen Sandilands; Dorothy Kisielewski; J Simon C Arthur; Timothy J Kendall; Lara Campana; Stuart J Forbes; Neil C Henderson; Tadashi Honda; Jingbo Pi; Takafumi Suzuki; Masayuki Yamamoto; Albena T Dinkova-Kostova; John D Hayes; null

The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2 色氨酸的亲电性代谢物——色氨酸-CKA，需要Keap1中的C151来去抑制Nrf2。

Redox Biology

IF11.9

2026-01-06

OAAI

Jialin Feng; Mara Carreño; Hannah Jung; Sharadha Dayalan Naidu; Nicole Arroyo-Diaz; Abel D. Ang; Bhargavi Kulkarni; Dorothy Kisielewski; Takafumi Suzuki; Masayuki Yamamoto; John D. Hayes; Tadashi Honda; Landon Wilson; Beatriz Leon-Ruiz; Aimee L. Eggler; Dario A. Vitturi; Albena T. Dinkova-Kostova

Genetic Deletion of RHAMM Alleviates Hepatic Oxidative Stress, Reversing Thyroid Stimulating Hormone Elevation in Male Obese Mice RHAMM基因敲除减轻雄性肥胖小鼠的肝氧化应激，逆转促甲状腺激素升高

Cells 2025, Vol. 14, Page 1448

IF5.2

2025-09-20

OAAI

Tianzhen Wang; Helin Sun; Ayman K. Banah; Xiong Weng; Sharadha Dayalan Naidu; Dot Kisielewski; Abel Ang; John D. Hayes; Albena T. Dinkova-Kostova; Li Kang

Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2 六羟基苯通过同时靶向Keap1和Gsk-3来调控转录因子Nrf2

Free Radical Biology and Medicine

IF8.2

2025-08-05

OAAI

Ángel J. García-Yagüe; Eduardo J. Cueto-Díaz; Maribel Escoll; Isao Okunishi; John D. Hayes; María Isabel Rodríguez-Franco; Ana I. Rojo; Antonio Cuadrado

Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases 健康立场文件与氧化还原视角——从实验室到临床：NRF2在非传染性疾病中的药理学调控过渡

REDOX BIOLOGY

IF11.9

2025-04-01

OAAI

Cuadrado, Antonio; Cazalla, Eduardo; Bach, Anders; Bathish, Boushra; Naidu, Sharadha Dayalan; Denicola, Gina M.; Dinkova-Kostova, Albena T.; Fernandez-Gines, Raquel; Grochot-Przeczek, Anna; Hayes, John D.; Kensler, Thomas W.; Leon, Rafael; Liby, Karen T.; Lopez, Manuela G.; Manda, Gina; Shivakumar, Akshatha Kalavathi; Hakomaki, Henriikka; Moerland, Jessica A.; Motohashi, Hozumi; Rojo, Ana I.; Sykiotis, Gerasimos P.; Taguchi, Keiko; Valverde, Angela M.; Yamamoto, Masayuki; Levonen, Anna-Liisa

Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis 调节Nrf2活性：泛素连接酶和信号分子在氧化还原稳态中的作用

TRENDS IN BIOCHEMICAL SCIENCES

IF11

2025-01-01

OAAI

Hayes, John D.; Naidu, Sharadha Dayalan; Dinkova-Kostova, Albena T.

Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells 糖原合酶激酶-3的抑制增强胰腺 β 细胞中NRF2蛋白的稳定性，核定位和靶基因转录

REDOX BIOLOGY

IF11.9

2024-05-01

OAAI

Patibandla, Chinmai; van Aalten, Lidy; Dinkova-Kostova, Albena T.; Honda, Tadashi; Cuadrado, Antonio; Fernandez-Gines, Raquel; Mcneilly, Alison D.; Hayes, John D.; Cantley, James; Sutherland, Calum

SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner SCF/β-trcp以Keap1-Independent方式促进糖原合酶激酶3依赖性Nrf2转录因子的降解

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

708

OAAI

Rada, Patricia; Rojo, Ana I.; Chowdhry, Sudhir; McMahon, Michael; Hayes, John D.; Cuadrado, Antonio

Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes 转录因子Nrf1负调节胱氨酸/谷氨酸转运体和脂质代谢酶

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Tsujita, Tadayuki; Peirce, Vivian; Baird, Liam; Matsuyama, Yuka; Takaku, Misaki; Walsh, Shawn V.; Griffin, Julian L.; Uruno, Akira; Yamamoto, Masayuki; Hayes, John D.

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis 糖原合酶激酶3/β-trcp轴降解Nrf2的结构和功能表征

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

319

OAAI

Rada, Patricia; Rojo, Ana I.; Evrard-Todeschi, Nathalie; Innamorato, Nadia G.; Cotte, Axelle; Jaworski, Tomasz; Tobon-Velasco, Julio C.; Devijver, Herman; Flor Garcia-Mayoral, Maria; Van Leuven, Fred; Hayes, John D.; Bertho, Gildas; Cuadrado, Antonio

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver 转录因子NRF2和E3泛素连接酶接头 β-trcp之间相互作用的抑制剂在小鼠肝脏中提供抗炎反应

REDOX BIOLOGY

IF11.9

2022-09-01

OAAI

Fernandez-Gines, Raquel; Antonio Encinar, Jose; Hayes, John D.; Oliva, Baldo; Isabel Rodriguez-Franco, Maria; Rojo, Ana, I; Cuadrado, Antonio

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver (vol 55, 102396, 2022)转录因子NRF2和E3泛素连接酶接头 β-trcp之间相互作用的抑制剂在小鼠肝脏中提供抗炎反应 (第55卷，102396，2022)

REDOX BIOLOGY

IF11.9

2022-09-01

OAAI

Fernandez-Gines, Raquel; Antonio Encinar, Jose; Hayes, John D.; Baldo, Oliva; Isabel Rodriguez-Franco, Maria; Rojo, Ana I.; Cuadrado, Antonio

Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2 非酒精性脂肪性肝炎及其通过激活cnc-bzip转录因子Nrf2改善的机制

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2022-08-01

OAAI

Bathish, Boushra; Robertson, Holly; Dillon, John F.; Dinkova-Kostova, Albena T.; Hayes, John D.

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress 轻度氧化应激对星形胶质细胞中Nrf2的非典型Keap1-independent激活

REDOX BIOLOGY

IF11.9

2021-11-01

OAAI

Al-Mubarak, Bashayer R.; Bell, Karen F. S.; Chowdhry, Sudhir; Meakin, Paul J.; Baxter, Paul S.; McKay, Sean; Dando, Owen; Ashford, Michael L. J.; Gazaryan, Irina; Hayes, John D.; Hardingham, Giles E.

Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells 转录因子NRF2诱导的抗氧化反应增加了人肺细胞中诱变空气污染物3-硝基苯并酮的生物活化

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2019-11-20

OAAI

Murray, Jessica R.; de la Vega, Laureano; Hayes, John D.; Duan, Ling; Penning, Trevor M.

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology 核因子红细胞2相关因子在毒理学和药理学中的新见解

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2019-03-01

OAAI

Pi, Jingbo; Hayes, John D.; Yamamoto, Masayuki

Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases NRF2和KEAP 1伙伴关系在慢性疾病中的治疗靶向性

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2019-01-04

950

OAAI

Cuadrado, Antonio; Rojo, Ana, I; Wells, Geoffrey; Hayes, John D.; Cousins, Sharon P.; Rumsey, William L.; Attucks, Otis C.; Franklin, Stephen; Levonen, Anna-Liisa; Kensler, Thomas W.; Dinkova-Kostova, Albena T.

Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2 锌结合触发控制转录因子NRF2的cullin-3底物衔接蛋白KEAP1的构象转换

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2018-12-01

OAAI

McMahon, Michael; Swift, Samuel R.; Hayes, John D.

A partnership with the proteasome; the destructive nature of GSK3 与蛋白酶体的伙伴关系; GSK3的破坏性

BIOCHEMICAL PHARMACOLOGY

IF5.6

2018-01-01

OAAI

Robertson, Holly; Hayes, John D.; Sutherland, Calum

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)实验性非酒精性脂肪性肝炎和肝纤维化通过Nrf2 (NF-E2 p45-Related因子2) 的药理学激活得到改善

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

IF7.4

2018-01-01

180

OAAI

Sharma, Ritu S.; Harrison, David J.; Kisielewski, Dorothy; Cassidy, Diane M.; McNeilly, Alison D.; Gallagher, Jennifer R.; Walsh, Shaun V.; Honda, Tadashi; McCrimmon, Rory J.; Dinkova-Kostova, Albena T.; Ashford, Michael L. J.; Dillon, John F.; Hayes, John D.

研究方向