Fen‐Biao Gao - Publications, H-index & Citations

Fen‐Biao Gao

university of massachusetts

62H指数

158论文数

2.5W被引数

收录论文 91

发表时间

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes 在不改变重复rna的情况下阻断RAN翻译可挽救C9ORF72-related ALS和FTD表型

Science

IF45.8

2026-02-05

PREAI

Xin Jiang; Laure Schaeffer; Divya Patni; Tommaso Russo; Chao-Zong Lee; Corey Aguilar; Christine Marques; Karen Jansen-West; Marian Hruska-Plochan; Ananya Ray-Soni; Su Min Lim; Aaron Held; Mei Yue; Paula Castellanos Otero; Sandeep Aryal; Hortense D. A. M. Beaussant; Himanish Basu; Hiro Takakuwa; Lillian M. Daughrity; Nandini Ramesh; Paulo Da Costa; Ana Rita A. A. Quadros; Matthew Nolan; Charles Jourdan F. Reyes; Hayden Wheeler; Laura C. Moran; Grant Griesman; Benjamin Wymann; Bianca A. Trombetta; Emma Sofia Lopez-De-Silanes; Michael Canori; Gopinath Krishnan; Yasmim Vieira Souza Da Silva; Gilbert Eriani; Mark W. Albers; Steven E. Arnold; Yuyu Song; Ankur Jain; Isaac M. Chiu; Yong-Jie Zhang; Fen-Biao Gao; Brian J. Wainger; Magdalini Polymenidou; Leonard Petrucelli; Franck Martin; Clotilde Lagier-Tourenne

The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD Ku80-p53-SIRT1轴在DNA损伤反应中对散发性ALS和家族性ALS及FTD有贡献。

Nature Communications

IF15.7

2025-12-20

OAAI

Yong-Woo Jun; Soojin Lee; Sandra Almeida; Kristine K. Freude; Justin K. Ichida; Fen-Biao Gao

Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons

SCIENCE SIGNALING

IF6.6

2024-08-06

OAAI

Dong, Daoyuan; Zhang, Zhe; Li, Yini; Latallo, Malgorzata J.; Wang, Shaopeng; Nelson, Blake; Wu, Rong; Krishnan, Gopinath; Gao, Fen-Biao; Wu, Bin; Sun, Shuying

The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD

CELL REPORTS

IF6.9

2024-07-01

OAAI

Halim, Dilara O.; Krishnan, Gopinath; Hass, Evan P.; Lee, Soojin; Verma, Mamta; Almeida, Sandra; Gu, Yuanzheng; Kwon, Deborah Y.; Fazzio, Thomas G.; Gao, Fen-Biao

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

FRONTIERS IN NEUROSCIENCE

IF3.2

2023-10-02

OAAI

Fang, Minggang; Deibler, Sara K.; Nana, Alissa L.; Vatsavayai, Sarat C.; Banday, Shahid; Zhou, You; Almeida, Sandra; Weiss, Alexandra; Brown, Robert H.; Seeley, William W.; Gao, Fen-Biao; Green, Michael R.

Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons 通过独特和冗余的AUG起始密码子翻译C9ORF72 ALS/FTD中的二肽重复蛋白

ELIFE

IF0

2023-09-07

OAAI

Sonobe, Yoshifumi; Lee, Soojin; Krishnan, Gopinath; Gu, Yuanzheng; Kwon, Deborah Y.; Gao, Fen-Biao; Roos, Raymond P.; Kratsios, Paschalis

Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features 尽管存在C9orf72病理特征，但C9orf72 ALS/FTD iPSC-小胶质细胞的中度内在表型改变

FRONTIERS IN CELLULAR NEUROSCIENCE

IF4

2023-06-06

OAAI

Lorenzini, Ileana; Alsop, Eric; Levy, Jennifer; Gittings, Lauren M.; Lall, Deepti; Rabichow, Benjamin E.; Moore, Stephen; Pevey, Ryan; Bustos, Lynette M.; Burciu, Camelia; Bhatia, Divya; Singer, Mo; Saul, Justin; McQuade, Amanda; Tzioras, Makis; Mota, Thomas A.; Logemann, Amber; Rose, Jamie; Almeida, Sandra; Gao, Fen-Biao; Marks, Michael; Donnelly, Christopher J.; Hutchins, Elizabeth; Hung, Shu-Ting; Ichida, Justin; Bowser, Robert; Spires-Jones, Tara; Blurton-Jones, Mathew; Gendron, Tania F.; Baloh, Robert H.; Van Keuren-Jensen, Kendall; Sattler, Rita

Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD

NEURON

IF15

2023-05-01

OAAI

Lee, Soojin; Jun, Yong -Woo; Linares, Gabriel R.; Butler, Brandon; Yuva-Adyemir, Yeliz; Moore, Jill; Krishnan, Gopinath; Ruiz-Juarez, Bryan; Santana, Manuel; Pons, Marine; Silverman, Neal; Weng, Zhiping; Ichida, Justin K.; Gao, Fen-Biao

The exocyst complex in neurological disorders

HUMAN GENETICS

IF3.6

2023-04-22

OAAI

Halim, Dilara O.; Munson, Mary; Gao, Fen-Biao

Dorsomedial prefrontal hypoexcitability underlies lost empathy in frontotemporal dementia

NEURON

IF15

2023-03-01

OAAI

Phillips, Hannah L.; Dai, Huihui; Choi, So Yoen; Jansen-West, Karen; Zajicek, Alexis S.; Daly, Luke; Petrucelli, Leonard; Gao, Fen-Biao; Yao, Wei-Dong

Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis

AUTOPHAGY

IF14.3

2023-02-27

OAAI

Jun, Yong-Woo; Lee, Soojin; Ban, Byung-Kwan; Lee, Jin-A; Gao, Fen-Biao

The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2022-11-22

OAAI

Chen, Yongping; Krishnan, Gopinath; Parsi, Sepideh; Pons, Marine; Nikolaki, Veroniki; Cao, Lu; Xu, Zuoshang; Gao, Fen-Biao

CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro

NATURE COMMUNICATIONS

IF15.7

2022-10-21

OAAI

Meijboom, Katharina E.; Abdallah, Abbas; Fordham, Nicholas P.; Nagase, Hiroko; Rodriguez, Tomas; Kraus, Carolyn; Gendron, Tania F.; Krishnan, Gopinath; Esanov, Rustam; Andrade, Nadja S.; Rybin, Matthew J.; Ramic, Melina; Stephens, Zachary D.; Edraki, Alireza; Blackwood, Meghan T.; Kahriman, Aydan; Henninger, Nils; Kocher, Jean-Pierre A.; Benatar, Michael; Brodsky, Michael H.; Petrucelli, Leonard; Gao, Fen-Biao; Sontheimer, Erik J.; Brown, Robert H.; Zeier, Zane; Mueller, Christian

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

NATURE COMMUNICATIONS

IF15.7

2022-05-19

OAAI

Loveland, Anna B.; Svidritskiy, Egor; Susorov, Denis; Lee, Soojin; Park, Alexander; Zvornicanin, Sarah; Demo, Gabriel; Gao, Fen-Biao; Korostelev, Andrei A.

Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD

NATURE COMMUNICATIONS

IF15.7

2022-05-19

OAAI

Krishnan, Gopinath; Raitcheva, Denitza; Bartlett, Daniel; Prudencio, Mercedes; McKenna-Yasek, Diane M.; Douthwright, Catherine; Oskarsson, Bjorn E.; Ladha, Shafeeq; King, Oliver D.; Barmada, Sami J.; Miller, Timothy M.; Bowser, Robert; Watts, Jonathan K.; Petrucelli, Leonard; Brown, Robert H.; Kankel, Mark W.; Gao, Fen-Biao

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

NEURON

IF15

2022-05-01

OAAI

Arredondo, Cristian; Cefaliello, Carolina; Dyrda, Agnieszka; Jury, Nur; Martinez, Pablo; Diaz, Ivan; Amaro, Armando; Tran, Helene; Morales, Danna; Pertusa, Maria; Stoica, Lorelei; Fritz, Elsa; Corvalan, Daniela; Abarzua, Sebastian; Mendez-Ruette, Maxs; Fernandez, Paola; Rojas, Fabiola; Kumar, Meenakshi Sundaram; Aguilar, Rodrigo; Almeida, Sandra; Weiss, Alexandra; Bustos, Fernando J.; Gonzalez-Nilo, Fernando; Otero, Carolina; Tevy, Maria Florencia; Bosco, Daryl A.; Saez, Juan C.; Kahne, Thilo; Gao, Fen-Biao; Berry, James D.; Nicholson, Katharine; Sena-Esteves, Miguel; Madrid, Rodolfo; Varela, Diego; Montecino, Martin; Brown, Robert H.; van Zundert, Brigitte

RNA targets of TDP-43: Which one is more important in neurodegeneration?

TRANSLATIONAL NEURODEGENERATION

IF15.2

2022-02-25

OAAI

Halim, Dilara; Gao, Fen-Biao

Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translation 核糖体分析揭示了含有C9ORF72 GGGGCC重复序列的RNA翻译的新调控

RNA

IF5

2021-11-30

OAAI

Spijker, Heleen M. van 't; Stackpole, Emily E.; Almeida, Sandra; Katsara, Olga; Liu, Botao; Shen, Kuang; Schneider, Robert J.; Gao, Fen-Biao; Richter, Joel D.

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

NATURE COMMUNICATIONS

IF15.7

2021-10-15

OAAI

Sonobe, Yoshifumi; Aburas, Jihad; Krishnan, Gopinath; Fleming, Andrew C.; Ghadge, Ghanashyam; Islam, Priota; Warren, Eleanor C.; Gu, Yuanzheng; Kankel, Mark W.; Brown, Andre E. X.; Kiskinis, Evangelos; Gendron, Tania F.; Gao, Fen-Biao; Roos, Raymond P.; Kratsios, Paschalis

Translation of the poly(GR) frame in C9ORF72-ALS/FTD is regulated by cis-elements involved in alternative splicing

NEUROBIOLOGY OF AGING

IF3.5

2021-09-01

OAAI

Lampasona, Alexa; Almeida, Sandra; Gao, Fen-Biao

研究方向