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A phase I trial of AVA6000, a fibroblast activation protein (FAP)-released, tumor microenvironment (TME)-targeted doxorubicin peptide drug conjugate in patients with FAP-positive solid tumors AVA6000的I期临床试验，该药物是一种成纤维细胞活化蛋白（FAP）释放、肿瘤微环境（TME）靶向的阿霉素肽偶联物，用于FAP阳性实体瘤患者。 Twelves, C. J.; Banerji, U.; Tap, W. D.; Cook, N.; Evans, T. R. J.; Plummer, R.; Anthoney, A.; Plummer, C.; Dawson, R.; Loadman, P.; Lahu, G.; Jones, H.; Kinnersley, N.; Edwards, R.; Gordon, G.; Cranmer, L. D. 分享 收藏
High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients 在未接种疫苗的新型冠状病毒肺炎患者中，高频率的 α 普通感冒冠状病毒/SARS-CoV-2交叉反应功能性CD4和CD8记忆T细胞与保护免受症状性和致命性SARS-CoV-2感染有关 Coulon, Pierre-Gregoire; Prakash, Swayam; Dhanushkodi, Nisha R.; Srivastava, Ruchi; Zayou, Latifa; Tifrea, Delia F.; Edwards, Robert A.; Figueroa, Cesar J.; Schubl, Sebastian D.; Hsieh, Lanny; Nesburn, Anthony B.; Kuppermann, Baruch D.; Bahraoui, Elmostafa; Vahed, Hawa; Gil, Daniel; Jones, Trevor M.; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
Cross-protection induced by highly conserved human B, CD4+, and CD8+ T-cell epitopes-based vaccine against severe infection, disease, and death caused by multiple SARS-CoV-2 variants of concern 基于高度保守的人B、CD4和CD8 T细胞表位的疫苗对多种SARS-CoV-2变异引起的严重感染、疾病和死亡的交叉保护作用 Prakash, Swayam; Dhanushkodi, Nisha R.; Zayou, Latifa; Ibraim, Izabela Coimbra; Quadiri, Afshana; Coulon, Pierre Gregoire; Tifrea, Delia F.; Suzer, Berfin; Shaik, Amin Mohammed; Chilukuri, Amruth; Edwards, Robert A.; Singer, Mahmoud; Vahed, Hawa; Nesburn, Anthony B.; Kuppermann, Baruch D.; Ulmer, Jeffrey B.; Gil, Daniel; Jones, Trevor M.; BenMohamed, Lbachir 分享 收藏
Antiviral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models Rage-ig蛋白对K18-hACE2小鼠和叙利亚金黄仓鼠模型中显示的多种SARS-CoV-2变异的抗病毒和抗炎治疗作用 Dhanushkodi, Nisha Rajeswari; Prakash, Swayam; Quadiri, Afshana; Zayou, Latifa; Srivastava, Ruchi; Shaik, Amin Mohammed; Suzer, Berfin; Ibraim, Izabela Coimbra; Landucci, Gary; Tifrea, Delia F.; Singer, Mahmoud; Jamal, Leila; Edwards, Robert A.; Vahed, Hawa; Brown, Lawrence; Benmohamed, Lbachir 分享 收藏
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis Evans, Katrina T.; Blake, Kerrigan; Longworth, Aaron; Coburn, Morgan A.; Insua-Rodriguez, Jacob; Mcmullen, Timothy P.; Nguyen, Quy H.; Ma, Dennis; Lev, Tatyana; Hernandez, Grace A.; Oganyan, Armani K.; Orujyan, Davit; Edwards, Robert A.; Pridans, Clare; Green, Kim N.; Villalta, S. Armando; Blurton-Jones, Mathew; Lawson, Devon A. 分享 收藏
Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism Chen, Yu-Han; Ta, Albert P.; Chen, Yumay; Lee, Hsiao-Chen; Fan, Wenjun; Chen, Phang-Lang; Jordan, Maria C.; Roos, Kenneth P.; MacGregor, Grant R.; Yang, Qin; Edwards, Robert A.; Li, Junfeng; Wang, Ping H. 分享 收藏
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress Seo, Gayoung; Yu, Clinton; Han, Han; Xing, Li; Kattan, Rebecca Elizabeth; An, Jeongmin; Kizhedathu, Amrutha; Yang, Bing; Luo, Annabella; Buckle, Abigail L.; Tifrea, Delia; Edwards, Robert; Huang, Lan; Ju, Huai-Qiang; Wang, Wenqi 分享 收藏
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease Hachey, Stephanie J.; Sobrino, Agua; Lee, John G.; Jafari, Mehraneh D.; Klempner, Samuel J.; Puttock, Eric J.; Edwards, Robert A.; Lowengrub, John S.; Waterman, Marian L.; Zell, Jason A.; Hughes, Christopher C. W. 分享 收藏
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Discovery of compounds that reactivate p53 mutants in vitro and in vivo Durairaj, Geetha; Demir, Ozlem; Lim, Bryant; Baronio, Robert; Tifrea, Delia; Hall, Linda V.; DeForest, Jacob C.; Lauinger, Linda; Fallatah, Maryam M. Jebril; Yu, Clinton; Bae, Hosung; Lin, Da-Wei; Kim, Jin Kwang; Salehi, Faezeh; Jang, Cholsoon; Qiao, Feng; Lathrop, Richard H.; Huang, Lan; Edwards, Robert; Rychnovsky, Scott; Amaro, Rommie E.; Kaiser, Peter 分享 收藏
Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer Chun, Sung Kook; Fortin, Bridget M.; Fellows, Rachel C.; Habowski, Amber N.; Verlande, Amandine; Song, Wei A.; Mahieu, Alisa L.; Lefebvre, Austin E. Y. T.; Sterrenberg, Jason N.; Velez, Leandro M.; Digman, Michelle A.; Edwards, Robert A.; Pannunzio, Nicholas R.; Seldin, Marcus M.; Waterman, Marian L.; Masri, Selma 分享 收藏
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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer Jahid, Sohail; Ortega, Jose A.; Vuong, Linh M.; Acquistapace, Isabella Maria; Hachey, Stephanie J.; Flesher, Jessica L.; La Serra, Maria Antonietta; Brindani, Nicoletta; La Sala, Giuseppina; Manigrasso, Jacopo; Arencibia, Jose M.; Bertozzi, Sine Mandrup; Summa, Maria; Bertorelli, Rosalia; Armirotti, Andrea; Jin, Rongsheng; Liu, Zheng; Chen, Chi-Fen; Edwards, Robert; Hughes, Christopher C. W.; De Vivo, Marco; Ganesan, Anand K. 分享 收藏
Disruption of β-Catenin-Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion Chen, George T.; Tifrea, Delia F.; Murad, Rabi; Habowski, Amber N.; Lyou, Yung; Duong, Madeleine R.; Hosohama, Linzi; Mortazavi, Ali; Edwards, Robert A.; Waterman, Marian L. 分享 收藏
Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice Olivarria, Gema M.; Cheng, Yuting; Furman, Susana; Pachow, Collin; Hohsfield, Lindsay A.; Smith-Geater, Charlene; Miramontes, Ricardo; Wu, Jie; Burns, Mara S.; Tsourmas, Kate, I; Stocksdale, Jennifer; Manlapaz, Cynthia; Yong, William H.; Teijaro, John; Edwards, Robert; Green, Kim N.; Thompson, Leslie M.; Lane, Thomas E. 分享 收藏
Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis Ma, Dennis; Hernandez, Grace A.; Lefebvre, Austin E. Y. T.; Alshetaiwi, Hamad; Blake, Kerrigan; Dave, Kushal R.; Rauf, Maha; Williams, Justice W.; Davis, Ryan T.; Evans, Katrina T.; Longworth, Aaron; Masoud, Madona Y. G.; Lee, Regis; Edwards, Robert A.; Digman, Michelle A.; Kessenbrock, Kai; Lawson, Devon A. 分享 收藏
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