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Wenying Shan

University of Macau

H指数:7

被引数:176

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AI-driven identification of a selective dual function inhibitor blocking HK2 activity and HK2-VDAC1 interaction displaying enhanced anticancer efficacy under hypoxia

AI驱动的选择性双功能抑制剂鉴定：该抑制剂可阻断HK2活性及HK2-VDAC1相互作用，并在缺氧条件下显示出增强的抗癌效果

European Journal of Medicinal Chemistry

IF5.9

2026-03-100

PRE

NF-κB activation as a pro-survival signal from pharmacological inhibition of pyruvate dehydrogenase kinase 1 in non-small-cell lung carcinoma cell models

Translational Oncology

IF4.1

2026-01-210

OAAI

Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation

联合抑制己糖激酶2和丙酮酸脱氢酶可克服携带KRAS Q61H突变的具有混合代谢状态的非小细胞肺癌的SHP2抑制剂耐药性

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

IF4.2

2025-06-180

PRE

Targeting hexokinase 2 to enhance anticancer efficacy of trichosanthin in HeLa and SCC25 cell models

IF4.3

2024-09-120

OAAI

Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing

IF10.1

2023-11-0111

PRE

GcForest-based compound-protein interaction prediction model and its application in discovering small-molecule drugs targeting CD47

基于GcForest的化合物-蛋白质相互作用预测模型及其在发现靶向CD47小分子药物中的应用

FRONTIERS IN CHEMISTRY

IF4.2

2023-10-203

OAAI

Epigallocatechin gallate circumvents drug-induced resistance in non-small-cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis

表没食子儿茶素没食子酸酯通过调节糖代谢和AMPK/AKT/MAPK轴来规避非小细胞肺癌的耐药性

PHYTOTHERAPY RESEARCH

IF6.3

2023-08-247

PRE

The development of small-molecule inhibitors targeting hexokinase 2

以己糖激酶2为靶点的小分子抑制剂研究进展

DRUG DISCOVERY TODAY

IF7.5

2022-09-0125

PRE

Convolutional Neural Network-based Virtual Screening

基于卷积神经网络的虚拟筛选

CURRENT MEDICINAL CHEMISTRY

IF3.5

2021-03-017

PRE