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K

Kin Yip Tam

university of macau

39H指数
195论文数
6.0K被引数
收录论文 95
发表时间
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Dynamic Evaluation Of The Glycolytic Determinants LDH-A And GLUT-1 Enhances Prognostic Significance And Their Inhibition Affect The Growth Of Mesothelioma Spheroids动态评估糖酵解决定因子LDH-A和GLUT-1可增强其预后意义，且它们的抑制影响间皮瘤球体的生长
errMolecular Metabolism
IF6.6
err2026-03-23
err0
errOAAI
errMarika A. Franczak; Federica Borea; Valentina Donati; Marta Aliprandi; Amir Avan; Valentina Doldi; Giulia Bononi; Kin Yip Tam; Carlotta Granchi; Ryszard T. Smolenski; Paolo A. Zucali; Filippo Minutolo; Godefridus J. Peters; Elisa Giovannetti
err分享
err收藏
AI-driven identification of a selective dual function inhibitor blocking HK2 activity and HK2-VDAC1 interaction displaying enhanced anticancer efficacy under hypoxiaAI驱动的选择性双功能抑制剂鉴定：该抑制剂可阻断HK2活性及HK2-VDAC1相互作用，并在缺氧条件下显示出增强的抗癌效果
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-03-10
err0
PREAI
errWenying Shan; Shao-Lin Zhang; Yehuda G. Assaraf; Kin Yip Tam
err分享
err收藏
p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Controlp62/SQSTM1凝聚体调节线粒体聚集以参与线粒体质量控制
errAging Cell
IF7.1
err2026-02-11
err0
errOAAI
errShan Sun; Jiaqi Xin; Yingping Zhang; Bojun Yang; Dan Su; Rui Ni; Qilian Ma; Ningning Li; Guoqiang Ma; Qiang Peng; Siqian Chen; Jochen H. M. Prehn; Kin Yip Tam; Hongfeng Wang; Zheng Ying
err分享
err收藏
NF-κB activation as a pro-survival signal from pharmacological inhibition of pyruvate dehydrogenase kinase 1 in non-small-cell lung carcinoma cell models
errTranslational Oncology
IF4.1
err2026-01-21
err0
errOAAI
errQuan Liu; Maoxin Ran; Wenying Shan; Shao-Lin Zhang; Kin Yip Tam
err分享
err收藏
miRNA-HK2 networks in cancer metabolism: Mechanisms and dual-targeting therapeutic opportunities癌症代谢中miRNA-HK2网络：机制与双靶点治疗机会
errBiochimica et Biophysica Acta (BBA) - Reviews on Cancer
IF0
err2026-01-06
err0
PREAI
errXinyue Jiang; Xinnan Li; Leo Tsz On Lee; Kin Yip Tam
err分享
err收藏
Integrative pan-cancer analysis identifies CCHCR1 as a prognostic biomarker and therapeutic target driving EMT in hepatocellular carcinoma via PI3K/AKT activation整合泛癌分析确定CCHCR1为预测性生物标志物和驱动肝细胞癌中EMT的PI3K/AKT激活的治疗靶点
errGenes & Diseases
IF9.4
err2025-11-28
err0
errOAAI
errShuting Huang; Wanqiu Li; Kaifang Wang; Yu Cai; Lirui Qian; Yiran Liu; Feng Gao; Tong Fang; Kin Yip Tam; Ou Sha
err分享
err收藏
PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesisPPP2/PP2A介导的LC3B去磷酸化将PINK1-PRKN/Parkin介导的线粒体自噬与SCA12发病机制联系起来
errAutophagy
IF14.3
err2025-10-13
err0
PREAI
errNingning Li; Hongyu Hou; Dan Su; Bojun Yang; Rui Ni; Guoqiang Ma; Shan Sun; Qilian Ma; Qiang Peng; Siqian Chen; Kin Yip Tam; Hongfeng Wang; Zheng Ying
err分享
err收藏
Identifying meaningful drug response biomarkers from public pharmacogenomic datasets with biologically informed interpretable neural networks从公共药物基因组学数据集中识别具有生物学信息解释性神经网络的药物反应生物标志物
errcomputational chemistry
IF3.1
err2025-09-02
err0
PREAI
errMaoxin Ran; Shao-Lin Zhang; Kin Yip Tam
err分享
err收藏
Targeting Metabolic Vulnerabilities Reveals Hexokinase 2 as a Key Mediator of Resistance to Osimertinib in Non-Small Cell Lung Cancer Models靶向代谢脆弱性揭示Hexokinase 2是Osimertinib在非小细胞肺癌模型中耐药的关键介导因子
errACS Pharmacology & Translational Science
IF3.7
err2025-07-08
err0
PREAI
errYizhen Guo; Ding Huang; Yan Zhou; Maoxin Ran; Shaolin Zhang; Kin Yip Tam
err分享
err收藏
Pharmacological interventions on GSK3β phosphorylation-mediated tau aggregation by modulating phase separation of tau proline-rich domain通过调控tau蛋白脯氨酸富集域的相分离，对GSK3β磷酸化介导的tau聚集进行药理学干预
errBiomedicine & Pharmacotherapy
IF7.5
err2025-06-27
err0
PREAI
errShan Sun; Siqian Chen; Junqiu He; Bojun Yang; Yingping Zhang; Ningning Li; Hongfeng Wang; Kin Yip Tam; Zheng Ying
err分享
err收藏
Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation联合抑制己糖激酶2和丙酮酸脱氢酶可克服携带KRAS Q61H突变的具有混合代谢状态的非小细胞肺癌的SHP2抑制剂耐药性
errBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
IF4.2
err2025-06-18
err0
PREAI
errShan, Wenying; Zhang, Shao-Lin; Assaraf, Yehuda G.; Tam, Kin Yip
err分享
err收藏
Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease
errNEUROSCIENCE BULLETIN
IF5.8
err2025-02-05
err0
PREAI
errHe, Junqiu; Sun, Shan; Wang, Hongfeng; Ying, Zheng; Tam, Kin Yip
err分享
err收藏
Targeting hexokinase 2 to enhance anticancer efficacy of trichosanthin in HeLa and SCC25 cell models
errADMET AND DMPK
IF4.3
err2024-09-12
err0
errOAAI
errZhou, Yan; Ran, Maoxin; Shan, Wenying; Wang, Kaifang; Sha, Ou; Tam, Kin Yip
err分享
err收藏
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction
errACTA PHARMACEUTICA SINICA B
IF14.6
err2024-05-01
err0
errOAAI
errXu, Shiqiang; Ma, Qilian; Shen, Junwen; Li, Ningning; Sun, Shan; Wang, Nana; Chen, Yang; Dong, Chunsheng; Tam, Kin Yip; Prehn, Jochen H. M.; Wang, Hongfeng; Ying, Zheng
err分享
err收藏
Dual-target inhibitors of cholinesterase disease胆碱酯酶疾病的双靶点抑制剂
errDRUG DISCOVERY TODAY
IF7.5
err2024-04-01
err3
PREAI
errHe, Junqiu; Tam, Kin Yip
err分享
err收藏
Combined inhibition of pyruvate dehydrogenase kinase 1 and hexokinase 2 induces apoptsis in non-small cell lung cancer cell models
errEXPERIMENTAL CELL RESEARCH
IF3.5
err2023-12-01
err3
PREAI
errGuo, Yizhen; Lu, Xianchen; Zhou, Yan; Chen, Wen-Hua; Tam, Kin Yip
err分享
err收藏
Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing
errCANCER LETTERS
IF10.1
err2023-11-01
err11
PREAI
errZhou, Yan; Guo, Yizhen; Ran, Maoxin; Shan, Wenying; Granchi, Carlotta; Giovannetti, Elisa; Minutolo, Filippo; Peters, Godefridus J.; Tam, Kin Yip
err分享
err收藏
Epigallocatechin gallate circumvents drug-induced resistance in non-small-cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis表没食子儿茶素没食子酸酯通过调节糖代谢和AMPK/AKT/MAPK轴来规避非小细胞肺癌的耐药性
errPHYTOTHERAPY RESEARCH
IF6.3
err2023-08-24
err7
PREAI
errZhou, Yan; Huang, Shiqi; Guo, Yizhen; Ran, Maoxin; Shan, Wenying; Chen, Wen-Hua; Tam, Kin Yip
err分享
err收藏
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture
errEMBO REPORTS
IF6.2
err2023-07-28
err9
PREAI
errMa, Qilian; Xin, Jiaqi; Peng, Qiang; Li, Ningning; Sun, Shan; Hou, Hongyu; Ma, Guoqiang; Wang, Nana; Zhang, Li; Tam, Kin Yip; Dussmann, Heiko; Prehn, Jochen H. M.; Wang, Hongfeng; Ying, Zheng
err分享
err收藏
Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance胞浆苹果酸酶和葡萄糖-6-磷酸脱氢酶调节获得性耐药NSCLC的氧化还原平衡
errFEBS JOURNAL
IF4.2
err2023-07-13
err5
PREAI
errRan, Maoxin; Zhou, Yan; Guo, Yizhen; Huang, Ding; Zhang, Shao-Lin; Tam, Kin Yip
err分享
err收藏

研究方向

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合作学者
合作期刊
R
Richard G. Compton
H 指数: 119 · 论文数: 1.7K
G
Godefridus J. Peters
H 指数: 103 · 论文数: 1.4K
S
Shik Chi Edman Tsang
H 指数: 96 · 论文数: 486
叶林 封面图
叶林 (Lin Ye)
H 指数: 91 · 论文数: 1.3K
I
Ian W. Hamley
H 指数: 87 · 论文数: 622
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