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Pekka T. Männistö

university of helsinki

H指数:55

被引数:1.2万

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The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson's Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On

NEUROLOGY AND THERAPY

IF4.8

2024-05-291

OAAI

Subacute administration of both methcathinone and manganese causes basal ganglia damage in mice resembling that in methcathinone abusers

JOURNAL OF NEURAL TRANSMISSION

IF4

2019-11-307

OAAI

Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis

MOLECULAR PSYCHIATRY

IF10.1

2017-08-2219

OAAI

Copy Number Variation of 22q11.2 Genes Arrests the Developmental Maturation of Working Memory Capacity and Adult Hippocampal Neurogenesis

BIOLOGICAL PSYCHIATRY

IF9

2017-05-010

PREAI

Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2017-02-1446

OAAI

Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2016-06-0128

PREAI

COMT gene locus: new functional variants

IF5.5

2015-10-0134

OAAI

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain

IF5.5

2014-11-0164

OAAI

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

NEUROBIOLOGY OF DISEASE

IF5.6

2014-08-0183

OAAI

Synthesis and biological evaluation of novel 123I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2014-05-014

PREAI

Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome

BIOCHEMICAL PHARMACOLOGY

IF5.6

2013-06-0120

PREAI

The Interactions of Dopamine and L-Dopa with Lipid Headgroup and its Implication for Neurotransmitters Metabolism

BIOPHYSICAL JOURNAL

IF3.1

2013-01-010

OAAI

High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

EJNMMI RESEARCH

IF3

2013-01-0122

OAAI

Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT

使用小动物SPECT/CT对小鼠进行高级脑多巴胺转运蛋白成像

EJNMMI RESEARCH

IF3

2012-09-293

OAAI

Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney

IF3

2012-09-0119

PREAI

Are Transglutaminase 2 Inhibitors Able to Reduce Gliadin-Induced Toxicity Related to Celiac Disease? A Proof-of-Concept Study

转谷氨酰胺酶2抑制剂能够减少与乳糜泻相关的麦醇溶蛋白诱导的毒性吗？概念验证研究

JOURNAL OF CLINICAL IMMUNOLOGY

IF5.7

2012-08-1044

PREAI

Different Interactions of Prolyl Oligopeptidase and Neurotensin in Dopaminergic Function of the Rat Nigrostriatal and Mesolimbic Pathways

NEUROCHEMICAL RESEARCH

IF3.8

2012-06-2312

PREAI

Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase

IF3

2012-06-0153

PREAI

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2012-05-08101

OAAI

Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats

EUROPEAN JOURNAL OF PAIN

IF3.4

2012-01-1312

PREAI