未登录 ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer Diciaccio, Benedetto; Seehawer, Marco; Li, Zheqi; Patmanidis, Andriana; Bui, Triet; Foidart, Pierre; Nishida, Jun; D'Santos, Clive S.; Papachristou, Evangelia K.; Papanastasiou, Malvina; Reiter, Andrew H.; Qiu, Xintao; Li, Rong; Jiang, Yijia; Huang, Xiao-Yun; Simeonov, Anton; Kales, Stephen C.; Rai, Ganesha; Lal-Nag, Madhu; Jadhav, Ajit; Brown, Myles; Carroll, Jason S.; Long, Henry W.; Polyak, Kornelia 分享 收藏
KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping Li, Zheqi; Peluffo, Guillermo; Stevens, Laura; Qiu, Xintao; Seehawer, Marco; Huang, Xiao-Yun; Egri, Shawn; Papanastasiou, Malvina; Kingston, Natalie; D'Santos, Clive; Papachristou, Eva; Nishida, Jun; Evans, Kyle; Seo, Ji-Heui; Clement, Kendell; Temko, Daniel; Ekram, Muhammad; Rees, Matthew; Ronan, Melissa; Roth, Jennifer; Simeonov, Anton; Kales, Stephen; Rai, Ganesha; Lal-Nag, Madhu; Maloney, David; Jadhav, Ajit; Michor, Franziska; Meissner, Alex; Balko, Justin; Carroll, Jason; Freedman, Matthew; Long, Henry; Jaffe, Jacob; Polyak, Kornelia 分享 收藏
A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells (vol 10, 4203, 2020) Asawa, Rosita R.; Danchik, Carina; Zakharov, Alexey; Chen, Yuchi; Voss, Ty; Jadhav, Ajit; Wallace, Darren P.; Trott, Josephine F.; Weiss, Robert H.; Simeonov, Anton; Martinez, Natalia J. 分享 收藏
A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2 Scoles, Daniel R.; Gandelman, Mandi; Paul, Sharan; Dexheimer, Thomas; Dansithong, Warunee; Figueroa, Karla P.; Pflieger, Lance T.; Redlin, Scott; Kales, Stephen C.; Sun, Hongmao; Maloney, David; Damoiseaux, Robert; Henderson, Mark J.; Simeonov, Anton; Jadhav, Ajit; Pulst, Stefan M. 分享 收藏
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis Frankowski, Kevin J.; Patnaik, Samarjit; Wang, Chen; Southall, Noel; Dutta, Dipannita; De, Soumitta; Li, Dandan; Dextras, Christopher; Lin, Yi-Han; Bryant-Connah, Marthe; Davis, Danielle; Wang, Feijun; Wachsmuth, Leah M.; Shah, Pranav; Williams, Jordan; Kabir, Md; Zhu, Edward; Baljinnyam, Bolormaa; Wang, Amy; Xu, Xin; Norton, John; Ferrer, Marc; Titus, Steve; Simeonov, Anton; Zheng, Wei; Griner, Lesley A. Mathews; Jadhav, Ajit; Aube, Jeffrey; Henderson, Mark J.; Rudloff, Udo; Schoenen, Frank J.; Huang, Sui; Marugan, Juan J. 分享 收藏
NCATS Inxight Drugs: a comprehensive and curated portal for translational research Siramshetty, Vishal B.; Grishagin, Ivan; Dac-Trung Nguyen; Peryea, Tyler; Skovpen, Yulia; Stroganov, Oleg; Katzel, Daniel; Sheils, Timothy; Jadhav, Ajit; Mathe, Ewy A.; Southall, Noel T. 分享 收藏
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy Gandelman, Mandi; Dansithong, Warunee; Kales, Stephen C.; Paul, Sharan; Maag, Gentrie; Aoyama, Erika; Zakharov, Alexey; Rai, Ganesha; Dexheimer, Thomas; Whitehill, Brooke M.; Sun, Hongmao; Jadhav, Ajit; Simeonov, Anton; Henderson, Mark J.; Huynh, Duong P.; Pulst, Stefan M.; Scoles, Daniel R. 分享 收藏
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2 Tsai, Wan-Chen; Gilbert, Nathan C.; Ohler, Amanda; Armstrong, Michelle; Perry, Steven; Kalyanaraman, Chakrapani; Yasgar, Adam; Rai, Ganesha; Simeonov, Anton; Jadhav, Ajit; Standley, Melissa; Lee, Hsiau-Wei; Crews, Phillip; Iavarone, Anthony T.; Jacobson, Matthew P.; Neau, David B.; Offenbacher, Adam R.; Newcomer, Marcia; Holman, Theodore R. 分享 收藏
Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells Singh, Anju; Dashynam, Myagmarjav; Chim, Bryan; Escobar, Thelma M.; Liu, Xiuhuai; Hu, Xin; Patnaik, Samarjit; Xu, Xin; Southall, Noel; Marugan, Juan; Jadhav, Ajit; Lazarevic, Vanja; Muljo, Stefan A.; Ferrer, Marc 分享 收藏
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer Rohde, Jason M.; Karavadhi, Surendra; Pragani, Rajan; Liu, Li; Fang, Yuhong; Zhang, Weihe; McIver, Andrew; Zheng, Hongchao; Liu, Qingyang; Davis, Mindy, I; Urban, Daniel J.; Lee, Tobie D.; Cheff, Dorian M.; Hollingshead, Melinda; Henderson, Mark J.; Martinez, Natalia J.; Brimacombe, Kyle R.; Yasgar, Adam; Zhao, Wei; Klumpp-Thomas, Carleen; Michael, Sam; Covey, Joseph; Moore, William J.; Stott, Gordon M.; Li, Zhuyin; Simeonov, Anton; Jadhav, Ajit; Frye, Stephen; Hall, Matthew D.; Shen, Min; Wang, Xiaodong; Patnaik, Samarjit; Boxer, Matthew B. 分享 收藏
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome Henderson, Mark J.; Trychta, Kathleen A.; Yang, Shyh-Ming; Back, Susanne; Yasgar, Adam; Wires, Emily S.; Danchik, Carina; Yan, Xiaokang; Yano, Hideaki; Shi, Lei; Wu, Kuo-Jen; Wang, Amy Q.; Tao, Dingyin; Zahoranszky-Kohalmi, Gergely; Hu, Xin; Xu, Xin; Maloney, David; Zakharov, Alexey, V; Rai, Ganesha; Urano, Fumihiko; Airavaara, Mikko; Gavrilova, Oksana; Jadhav, Ajit; Wang, Yun; Simeonov, Anton; Harvey, Brandon K. 分享 收藏
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites Dorjsuren, Dorjbal; Eastman, Richard T.; Wicht, Kathryn J.; Jansen, Daniel; Talley, Daniel C.; Sigmon, Benjamin A.; Zakharov, Alexey V.; Roncal, Norma; Girvin, Andrew T.; Antonova-Koch, Yevgeniya; Will, Paul M.; Shah, Pranav; Sun, Hongmao; Klumpp-Thomas, Carleen; Mok, Sachel; Yeo, Tomas; Meister, Stephan; Marugan, Juan Jose; Ross, Leila S.; Xu, Xin; Maloney, David J.; Jadhav, Ajit; Mott, Bryan T.; Sciotti, Richard J.; Winzeler, Elizabeth A.; Waters, Norman C.; Campbell, Robert F.; Huang, Wenwei; Simeonov, Anton; Fidock, David A. 分享 收藏
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors Abrams, Rachel P. M.; Yasgar, Adam; Teramoto, Tadahisa; Lee, Myoung-Hwa; Dorjsuren, Dorjbal; Eastman, Richard T.; Malik, Nasir; Zakharov, Alexey V.; Li, Wenxue; Bachani, Muzna; Brimacombe, Kyle; Steiner, Joseph P.; Hall, Matthew D.; Balasubramanian, Anuradha; Jadhav, Ajit; Padmanabhan, Radhakrishnan; Simeonov, Anton; Nath, Avindra 分享 收藏
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties Rai, Ganesha; Urban, Daniel J.; Mott, Bryan T.; Hu, Xin; Yang, Shyh-Ming; Benavides, Gloria A.; Johnson, Michelle S.; Squadrito, Giuseppe L.; Brimacombe, Kyle R.; Lee, Tobie D.; Cheff, Dorian M.; Zhu, Hu; Henderson, Mark J.; Pohida, Katherine; Sulikowski, Gary A.; Dranow, David M.; Kabir, Md; Shah, Pranav; Padilha, Elias; Tao, Dingyin; Fang, Yuhong; Christov, Plamen P.; Kim, Kwangho; Jana, Somnath; Muttil, Pavan; Anderson, Tamara; Kunda, Nitesh K.; Hathaway, Helen J.; Kusewitt, Donna F.; Oshima, Nobu; Cherukuri, Murali; Davies, Douglas R.; Norenberg, Jeffrey P.; Sklar, Larry A.; Moore, William J.; Dang, Chi, V; Stott, Gordon M.; Neckers, Leonard; Flint, Andrew J.; Darley-Usmar, Victor M.; Simeonov, Anton; Waterson, Alex G.; Jadhav, Ajit; Hall, Matthew D.; Maloney, David J. 分享 收藏
Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer Flach, Koen D.; Periyasamy, Manikandan; Jadhav, Ajit; Dorjsuren, Dorjbal; Siefert, Joseph C.; Hickey, Theresa E.; Opdam, Mark; Patel, Hetal; Canisius, Sander; Wilson, David M., III; Collier, Maria Donaldson; Prekovic, Stefan; Nieuwland, Marja; Kluin, Roelof J. C.; Zakharov, Alexey, V; Wesseling, Jelle; Wessels, Lodewyk F. A.; Linn, Sabine C.; Tilley, Wayne D.; Simeonov, Anton; Ali, Simak; Zwart, Wilbert 分享 收藏
Identification of Small Molecule Enhancers of Immunotherapy for Melanoma Dextras, Christopher; Dashnyam, Myagmarjav; Griner, Lesley A. Mathews; Sundaresan, Janani; Chim, Bryan; Yu, Zhiya; Vodnala, Suman; Lee, Chyi-Chia Richard; Hu, Xin; Southall, Noel; Marugan, Juan J.; Jadhav, Ajit; Restifo, Nicholas P.; Acquavella, Nicolas; Ferrer, Marc; Singh, Anju 分享 收藏
A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells Asawa, Rosita R.; Danchik, Carina; Zahkarov, Alexey; Chen, Yuchi; Voss, Ty; Jadhav, Ajit; Wallace, Darren P.; Trott, Josephine F.; Weiss, Robert H.; Simeonov, Anton; Martinez, Natalia J. 分享 收藏
Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells Singh, Anju; Dashnyam, Myagmarjav; Chim, Bryan; Escobar, Thelma M.; Dulcey, Andres E.; Hu, Xin; Wilson, Kelli M.; Koganti, Prasanthi P.; Spinner, Camille A.; Xu, Xin; Jadhav, Ajit; Southall, Noel; Marugan, Juan; Selvaraj, Vimal; Lazarevic, Vanja; Muljo, Stefan A.; Ferrer, Marc 分享 收藏
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy 肿瘤中LDH抑制的动态成像揭示了快速的体内代谢重组和对联合治疗的脆弱性 Oshima, Nobu; Ishida, Ryo; Kishimoto, Shun; Beebe, Kristin; Brender, Jeffrey R.; Yamamoto, Kazutoshi; Urban, Daniel; Rai, Ganesha; Johnson, Michelle S.; Benavides, Gloria; Squadrito, Giuseppe L.; Crooks, Dan; Jackson, Joseph; Joshi, Abhinav; Mott, Bryan T.; Shrimp, Jonathan H.; Moses, Michael A.; Lee, Min-Jung; Yuno, Akira; Lee, Tobie D.; Hu, Xin; Anderson, Tamara; Kusewitt, Donna; Hathaway, Helen H.; Jadhav, Ajit; Picard, Didier; Trepel, Jane B.; Mitchell, James B.; Stott, Gordon M.; Moore, William; Simeonov, Anton; Sklar, Larry A.; Norenberg, Jeffrey P.; Linehan, W. Marston; Maloney, David J.; Dang, Chi V.; Waterson, Alex G.; Hall, Matthew; Darley-Usmar, Victor M.; Krishna, Murali C.; Neckers, Leonard M. 分享 收藏
Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis Lyu, Haining; Petukhov, Pavel A.; Banta, Paul R.; Jadhav, Ajit; Lea, Wendy A.; Cheng, Qing; Arner, Elias S. J.; Simeonov, Anton; Thatcher, Gregory R. J.; Angelucci, Francesco; Williams, David L. 分享 收藏
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