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张霖 封面图

张霖 (Lin Zhang)

albert-ludwigs-universität freiburg教授
H指数:31
被引数:2,813

个人简介

深圳理工大学合成生物学院特聘教授，国家级海外青年人才项目获得者、深圳市“鹏城孔雀计划”特聘岗位B档入选者。主要研究方向为微生物来源的关键金属酶和膜蛋白的生物化学与结构生物学。近年代表性成果发表于Nature, Nat Chem Biol, Nat Commun, Proc Natl Acad Sci USA, J Am Chem Soc, Angew Chem Int Ed等期刊。

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

  1. 国家级海外青年人才项目
  2. 深圳市“鹏城孔雀计划”特聘岗位B档入选者
From Pharmacophore to Warhead: NAD+-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors

从药效团到Warhead：靶向NAD+的三唑类作为机制性SirTuin抑制剂

Angewandte Chemie International Edition
IF16.9
2025-10-300
OAAI
Florian Friedrich; Dr. Marat Meleshin; Niklas Papenkordt; Lena Gaitzsch; Isabel Prucker; Dr. Marco Borso; Jan Ruprecht; Christopher Vorreiter; Sabrina Rast; Prof. Lin Zhang; Prof. Matthias Schiedel; Prof. Wolfgang Sippl; Prof. Axel Imhof; Prof. Henning J. Jessen; Prof. Oliver Einsle; Prof. Mike Schutkowski; Prof. Manfred Jung
Structure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity

结构导向的KMT9抑制剂前药设计及其细胞活性

Journal of Medicinal Chemistry
IF6.8
2025-06-170
OA
Sheng Wang; Nicolas P. F. Barthes; Sylvia Urban; Viktor I. Hazai; Sebastian O. Klein; Tabea Pappert; Paul Kümmel; Nicolas Heller; Johannes Bacher; Maximilian Staudt; Jan Ruprecht; Ling Peng; Manuela Sum; Christopher Berlin; Daad Sarraf; Pierre Regenass; Robin Warstat; Johannes Walz; Pankaj Mishra; Lin Zhang; Oliver Einsle; Stefan Günther; Bernhard Breit; Eric Metzger; Manfred Jung; Roland Schüle
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
NATURE COMMUNICATIONS
IF15.7
2024-01-022
OAAI
Wang, Sheng; Klein, Sebastian O.; Urban, Sylvia; Staudt, Maximilian; Barthes, Nicolas P. F.; Willmann, Dominica; Bacher, Johannes; Sum, Manuela; Bauer, Helena; Peng, Ling; Rennar, Georg A.; Gratzke, Christian; Schuele, Katrin M.; Zhang, Lin; Einsle, Oliver; Greschik, Holger; Macleod, Calum; Thomson, Christopher G.; Jung, Manfred; Metzger, Eric; Schuele, Roland
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-10-309
OAAI
Sinatra, Laura; Vogelmann, Anja; Friedrich, Florian; Tararina, Margarita A.; Neuwirt, Emilia; Colcerasa, Arianna; Koenig, Philipp; Toy, Lara; Yesiloglu, Talha Z.; Hilscher, Sebastian; Gaitzsch, Lena; Papenkordt, Niklas; Zhai, Shiyang; Zhang, Lin; Romier, Christophe; Einsle, Oliver; Sippl, Wolfgang; Schutkowski, Mike; Gross, Olaf; Bendas, Gerd; Christianson, David W.; Hansen, Finn K.; Jung, Manfred; Schiedel, Matthias
Metagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease

宏基因组范围的分析揭示了肠道微生物特征，并暗示了终末期肾脏疾病中的分类单元特异性功能

GENOME BIOLOGY
IF9.4
2023-10-128
OAAI
Zhang, Pan; Wang, Xifan; Li, Shenghui; Cao, Xuesen; Zou, Jianzhou; Fang, Yi; Shi, Yiqin; Xiang, Fangfang; Shen, Bo; Li, Yixuan; Fang, Bing; Zhang, Yue; Guo, Ruochun; Lv, Qingbo; Zhang, Liwen; Lu, Yufei; Wang, Yaqiong; Yu, Jinbo; Xie, Yeqing; Wang, Ran; Chen, Xiaohong; Yu, Jiawei; Zhang, Zhen; He, Jingjing; Zhan, Jing; Lv, Wenlv; Nie, Yuxin; Cai, Jieru; Xu, Xialian; Hu, Jiachang; Zhang, Qi; Gao, Ting; Jiang, Xiaotian; Tan, Xiao; Xue, Ning; Wang, Yimei; Ren, Yimei; Wang, Li; Zhang, Han; Ning, Yichun; Chen, Jing; Zhang, Lin; Jin, Shi; Ren, Fazheng; Ehrlich, Stanislav Dusko; Zhao, Liang; Ding, Xiaoqiang

研究方向

金属酶和膜蛋白作用机制微生物细胞工厂改造药物设计
O
Oliver Einsle
H 指数:56论文数:430被引数:1.4万
M
Manfred Jung
H 指数:65论文数:469被引数:1.3万
Z
Zeyi Wu
H 指数:20论文数:53被引数:2,433
胡林峰 封面图
胡林峰
H 指数:62论文数:242被引数:1.4万
G
Guoping Zhao
H 指数:82论文数:747被引数:3.7万
W
Wolfgang Sippl
H 指数:64论文数:504被引数:1.3万
丁
丁晓明
H 指数:19论文数:67被引数:1,096
L
Le Jiang
H 指数:42论文数:222被引数:1.1万
O
Olaf Groß
H 指数:44论文数:151被引数:1.3万
E
Eric Metzger
H 指数:36论文数:119被引数:6,709