Wieslaw M. Kazmierski - Publications, H-index & Citations

Wieslaw M. Kazmierski

GlaxoSmithKline

31H指数

111论文数

5.1K被引数

收录论文 23

发表时间

The Discovery of Conformationally Constrained Bicyclic Peptidomimetics as Potent Hepatitis C NS5A Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-09-15

OAAI

Kazmierski, Wieslaw M.; Miriyala, Nagaraju; Johnson, David K.; Baskaran, Sam

GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-03-23

PREAI

Kazmierski, Wieslaw M.; Baskaran, Sam; Walker, Jill T.; Miriyala, Nagaraju; Meesala, Ramu; Beesu, Mallesh; Adjabeng, George; Grimes, Richard M.; Hamatake, Robert; Leivers, Martin R.; Crosby, Renae; Xia, Bing; Remlinger, Katja

DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-02-19

PREAI

Kazmierski, Wieslaw M.; Xia, Bing; Miller, John; De la Rosa, Martha; Favre, David; Dunham, Richard M.; Washio, Yoshiaki; Zhu, Zhengrong; Wang, Feng; Mebrahtu, Makda; Deng, Hongfeng; Basilla, Jonathan; Wang, Liping; Evindar, Ghotas; Fan, Lijun; Olszewski, Alison; Prabhu, Ninad; Davie, Christopher; Messer, Jeffrey A.; Samano, Vicente

Biological and Structural Characterization of Rotamers of C-C Chemokine Receptor Type 5 (CCR5) Inhibitor G5K214096

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2014-11-12

OAAI

Kazmierski, Wieslaw M.; Danehower, Susan; Duan, Maosheng; Ferris, Robert G.; Elitzin, Vassil; Minick, Douglas; Sharp, Matthew; Stewart, Eugene; Villeneuve, Manon

Novel Spiroketal Pyrrolidine GSK2336805 Potently Inhibits Key Hepatitis C Virus Genotype 1b Mutants: From Lead to Clinical Compound

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-02-26

PREAI

Kazmierski, Wieslaw M.; Maynard, Andrew; Duan, Maosheng; Baskaran, Sam; Botyanszki, Janos; Crosby, Renae; Dickerson, Scott; Tallant, Matthew; Grimes, Rick; Hamatake, Robert; Leivers, Martin; Roberts, Christopher D.; Walker, Jill

Pharmacological disruption of hepatitis C NS5A protein intra- and intermolecular conformations

JOURNAL OF GENERAL VIROLOGY

IF4.3

2014-02-01

OAAI

Bhattacharya, Dipankar; Ansari, Israrul H.; Hamatake, Robert; Walker, Jill; Kazmierski, Wieslaw M.; Striker, Rob

Preclinical Characterization of GSK2336805, a Novel Inhibitor of Hepatitis C Virus Replication That Selects for Resistance in NS5A

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2014-01-01

OAAI

Walker, Jill; Crosby, Renae; Wang, Amy; Woldu, Ermias; Vamathevan, Jessica; Voitenleitner, Christian; You, Shihyun; Remlinger, Katja; Duan, Maoshang; Kazmierski, Wieslaw; Hamatake, Robert

Discovery of Novel Urea-Based Hepatitis C Protease Inhibitors with High Potency against Protease-Inhibitor-Resistant Mutants

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-04-03

PREAI

Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Copper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang

Novel 4,4-Disubstituted Piperidine-Based C-C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-05-17

PREAI

Kazmierski, Wieslaw M.; Anderson, Don L.; Aquino, Christopher; Chauder, Brian A.; Duan, Maosheng; Ferris, Robert; Kenakin, Terrence; Koble, Cecilia S.; Lang, Dan G.; Mcintyre, Maggie S.; Peckham, Jennifer; Watson, Christian; Wheelan, Pat; Spaltenstein, Andrew; Wire, Mary B.; Svolto, Angilique; Youngman, Michael

IN VITRO PROFILING OF GSK2336805, A POTENT AND SELECTIVE INHIBITOR OF HCV NS5A

JOURNAL OF HEPATOLOGY

IF33

2011-03-01

PREAI

Bechtel, J.; Crosby, R.; Wang, A.; Woldu, E.; Van Horn, S.; Horton, J.; Creech, K.; Caballo, L. H.; Voitenleitner, C.; Vamathevan, J.; Duan, M.; Spaltenstein, A.; Kazmierski, W.; Roberts, C.; Hamatake, R.

The Relative Activity of Function Sparing HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property?

MOLECULAR PHARMACOLOGY

IF3

2009-03-01

PREAI

Muniz-Medina, Vanessa M.; Jones, Stacey; Maglich, Jodi M.; Galardi, Cristin; Hollingsworth, Robert E.; Kazmierski, Wieslaw M.; Ferris, Robert G.; Edelstein, Mark P.; Chiswell, Karen E.; Kenakin, Terry P.

Discovery of Bioavailable 4,4-Disubstituted Piperidines as Potent Ligands of the Chemokine Receptor 5 and Inhibitors of the Human Immunodeficiency Virus-1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-09-24

PREAI

Kazmierski, Wieslaw M.; Aquino, Christopher; Chauder, Brian A.; Deanda, Felix; Ferris, Robert; Jones-Hertzog, Deborah K.; Kenakin, Terrence; Koble, Cecilia S.; Watson, Christian; Wheelan, Pat; Yang, Hanbiao; Youngman, Michael

A new experimental method to determine the mutual orientation of helices in coiled-coil proteins: Structural information about the dimeric interface of cJun, cFos, GCN4, and gp41

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2006-01-20

PREAI

Kazmierski, WM; McDermed, J; Aulabaugh, A

Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2005-12-21

PREAI

Kazmierski, WM; Kenakin, TP; Gudmundsson, KS

The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

MOLECULAR PHARMACOLOGY

IF3

2005-04-01

286

PREAI

Watson, C; Jenkinson, S; Kazmierski, W; Kenakin, T

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors (vol 11, pg 2663, 2003)

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2003-09-01

PREAI

Kazmierski, W; Bifulco, N; Yang, HB; Boone, L; DeAnda, F; Watson, C; Kenakin, T

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2003-07-01

128

PREAI

Kazmierski, W; Bifulco, N; Yang, HB; Boone, L; DeAnda, F; Watson, C; Kenakin, T

NEW AMINO-ACIDS FOR THE TOPOGRAPHICAL CONTROL OF PEPTIDE CONFORMATION - SYNTHESIS OF ALL THE ISOMERS OF ALPHA,BETA-DIMETHYLPHENYLALANINE AND ALPHA,BETA-DIMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID OF HIGH OPTICAL PURITY

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2002-05-01

PREAI

KAZMIERSKI, WM; URBANCZYKLIPKOWSKA, Z; HRUBY, VJ

TOPOGRAPHIC DESIGN OF PEPTIDE NEUROTRANSMITTERS AND HORMONES ON STABLE BACKBONE TEMPLATES - RELATION OF CONFORMATION AND DYNAMICS TO BIOACTIVITY

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2002-05-01

140

PREAI

KAZMIERSKI, WM; YAMAMURA, HI; HRUBY, VJ

N-(2-benzoylphenyl)-L-tyrosine PPARγ agonists.: 2.: Structure-activity relationship and optimization of the phenyl alkyl ether moiety

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

1998-11-06

142

PREAI

Collins, JL; Blanchard, SG; Boswell, GE; Charifson, PS; Cobb, JE; Henke, BR; Hull-Ryde, EA; Kazmierski, WM; Lake, DH; Leesnitzer, LM; Lehmann, J; Lenhard, JM; Orband-Miller, LA; Gray-Nunez, Y; Parks, DJ; Plunkett, KD; Tong, WQ

研究方向