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收藏Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases
Patel, Snahel; Chen, Huifen; Varfolomeev, Eugene; Kwon, Youngsu; Ramaswamy, Sreemathy; Kohli, Pawan Bir; Quinn, John G.; Webster, Joshua D.; Mao, Jialin; Chen, Yuan; Fong, Rina; Demircioglu, F. Esra; Lupardus, Patrick; Stivala, Craig; Hamilton, Gregory L.; Siu, Michael; Sujatha-Bhaskar, Swathi; Mohanan, Vishnu; Adedeji, Adeyemi O.; Santagostino, Sara F.; Maher, Jonathan; Mckenzie, Brent; Rothenberg, Michael E.; Johnson, Adam; Vucic, Domagoj 分享 收藏 分享 收藏 Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancerGalsky, Matthew D.; Guan, Xiangnan; Rishipathak, Deepali; Rapaport, Aaron S.; Shehata, Hesham M.; Banchereau, Romain; Yuen, Kobe; Varfolomeev, Eugene; Hu, Ruozhen; Han, Chia -Jung; Li, Haocheng; Liang, Yuxin; Vucic, Domagoj; Wang, Li; Zhu, Jun; Yu, Haocheng; Herbst, Rebecca H.; Hajaj, Emma; Kiner, Evgeny; Bamias, Aristotelis; De Santis, Maria; Davis, Ian D.; Arranz, Jose Angel; Kikuchi, Eiji; Bernhard, Sandrine; Williams, Patrick; Lee, Chooi; Mellman, Ira; Sanjabi, Shomyseh; Johnston, Robert; Black, Peter C.; Grande, Enrique; Mariathasan, Sanjeev 分享 收藏 Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2Goncharov, Tatiana; Komuves, Laszlo G.; Kist, Matthias; Castellanos, Erick R.; Witt, Axel; Fedorova, Anna V.; Izrael-Tomasevic, Anita; Yu, Kebing; Keir, Mary; Matsumoto, Marissa L.; Vucic, Domagoj 分享 收藏 Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effectsPrado-Acosta, Mariano; Jeong, Seihwan; Utrero-Rico, Alberto; Goncharov, Tatiana; Webster, Joshua D.; Holler, Ernst; Morales, George; Dellepiane, Sergio; Levine, John E.; Rothenberg, Michael E.; Vucic, Domagoj; Ferrara, James L. M. 分享 收藏 cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammationSchorn, Fabian; Werthenbach, J. Paul; Hoffmann, Mattes; Daoud, Mila; Stachelscheid, Johanna; Schiffmann, Lars M.; Hildebrandt, Ximena; Lyu, Su Ir; Peltzer, Nieves; Quaas, Alexander; Vucic, Domagoj; Silke, John; Pasparakis, Manolis; Kashkar, Hamid 分享 收藏 A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteersJones, Nicholas S.; Kshirsagar, Smita; Mohanan, Vishnu; Ramakrishnan, Vidya; Di Nucci, Flavia; Ma, Ling; Mao, Jialin; Ding, Hao; Klabunde, Sha; Vucic, Domagoj; Pan, Lin; Lekkerkerker, Annemarie N.; Chen, Yuan; Rothenberg, Michael E. 分享 收藏 Apoptotic cell death in disease-Current understanding of the NCCD 2023疾病中的凋亡细胞死亡-对NCCD 2023的当前理解Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Aqeilan, Rami, I; Arama, Eli; Baehrecke, Eric H.; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A.; Bartek, Jiri; Bazan, Nicolas G.; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu J. M.; Bianchi, Marco E.; Blagosklonny, Mikhail V.; Blander, J. Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D.; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A.; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Ciliberto, Gennaro; Conrad, Marcus; Cubillos-Ruiz, Juan R.; Czabotar, Peter E.; D'Angiolella, Vincenzo; Daugaard, Mads; Dawson, Ted M.; Dawson, Valina L.; De Maria, Ruggero; De Strooper, Bart; Debatin, Klaus-Michael; Deberardinis, Ralph J.; Degterev, Alexei; Del Sal, Giannino; Deshmukh, Mohanish; Di Virgilio, Francesco; Diederich, Marc; Dixon, Scott J.; Dynlacht, Brian D.; El-Deiry, Wafik S.; Elrod, John W.; Engeland, Kurt; Fimia, Gian Maria; Galassi, Claudia; Ganini, Carlo; Garcia-Saez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Gerlic, Motti; Ghosh, Sourav; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Haecker, Georg; Hajnoczky, Gyorgy; Hardwick, J. Marie; Haupt, Ygal; He, Sudan; Heery, David M.; Hengartner, Michael O.; Hetz, Claudio; Hildeman, David A.; Ichijo, Hidenori; Inoue, Satoshi; Jaeaettelae, Marja; Janic, Ana; Joseph, Bertrand; Jost, Philipp J.; Kanneganti, Thirumala-Devi; Karin, Michael; Kashkar, Hamid; Kaufmann, Thomas; Kelly, Gemma L.; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Kluck, Ruth; Krysko, Dmitri, V; Kulms, Dagmar; Kumar, Sharad; Lavandero, Sergio; Lavrik, Inna N.; Lemasters, John J.; Liccardi, Gianmaria; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; Lopez-Otin, Carlos; Luedde, Tom; MacFarlane, Marion; Madeo, Frank; Malorni, Walter; Manic, Gwenola; Mantovani, Roberto; Marchi, Saverio; Marine, Jean-Christophe; Martin, Seamus J.; Martinou, Jean-Claude; Mastroberardino, Pier G.; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Gerry; Melino, Sonia; Miao, Edward A.; Moll, Ute M.; Munoz-Pinedo, Cristina; Murphy, Daniel J.; Niklison-Chirou, Maria Victoria; Novelli, Flavia; Nunez, Gabriel; Oberst, Andrew; Ofengeim, Dimitry; Opferman, Joseph T.; Oren, Moshe; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pentimalli, Francesca; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Pinton, Paolo; Porta, Giovanni; Prehn, Jochen H. M.; Puthalakath, Hamsa; Rabinovich, Gabriel A.; Rajalingam, Krishnaraj; Ravichandran, Kodi S.; Rehm, Markus; Ricci, Jean-Ehrland; Rizzuto, Rosario; Robinson, Nirmal; Rodrigues, Cecilia M. P.; Rotblat, Barak; Rothlin, Carla, V; Rubinsztein, David C.; Rudel, Thomas; Rufini, Alessandro; Ryan, Kevin M.; Sarosiek, Kristopher A.; Sawa, Akira; Sayan, Emre; Schroder, Kate; Scorrano, Luca; Sesti, Federico; Shao, Feng; Shi, Yufang; Sica, Giuseppe S.; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stephanou, Anastasis; Stockwell, Brent R.; Strapazzon, Flavie; Strasser, Andreas; Sun, Liming; Sun, Erwei; Sun, Qiang; Szabadkai, Gyorgy; Tait, Stephen W. G.; Tang, Daolin; Tavernarakis, Nektarios; Troy, Carol M.; Turk, Boris; Urbano, Nicoletta; Vandenabeele, Peter; Vanden Berghe, Tom; Vander Heiden, Matthew G.; Vanderluit, Jacqueline L.; Verkhratsky, Alexei; Villunger, Andreas; von Karstedt, Silvia; Voss, Anne K.; Vousden, Karen H.; Vucic, Domagoj; Vuri, Daniela; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ruoning; Wang, Ying; Weber, Achim; Wood, Will; Yamazaki, Takahiro; Yang, Huang-Tian; Zakeri, Zahra; Zawacka-Pankau, Joanna E.; Zhang, Lin; Zhang, Haibing; Zhivotovsky, Boris; Zhou, Wenzhao; Piacentini, Mauro; Kroemer, Guido; Galluzzi, Lorenzo 分享 收藏 XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated deathWitt, Axel; Goncharov, Tatiana; Lee, Yujung Michelle; Kist, Matthias; Dohse, Monika; Eastham, Jeff; Dugger, Debra; Newton, Kim; Webster, Joshua D.; Vucic, Domagoj 分享 收藏 分享 收藏 XIAP promotes melanoma growth by inducing tumour neutrophil infiltrationXIAP通过诱导肿瘤中性粒细胞浸润促进黑色素瘤生长Daoud, Mila; Broxtermann, Pia Nora; Schorn, Fabian; Werthenbach, J. Paul; Seeger, Jens Michael; Schiffmann, Lars M.; Brinkmann, Kerstin; Vucic, Domagoj; Tuting, Thomas; Mauch, Cornelia; Kulms, Dagmar; Zigrino, Paola; Kashkar, Hamid 分享 收藏 Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Proteinden Besten, Willem; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M.; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J.; Wertz, Ingrid; Yu, Kebing; Staben, Steven T. 分享 收藏 Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injuryStark, Kimberly; Goncharov, Tatiana; Varfolomeev, Eugene; Xie, Luke; Ngu, Hai; Peng, Ivan; Anderson, Keith R.; Verschueren, Erik; Choi, Meena; Kirkpatrick, Donald S.; Easton, Amy; Webster, Joshua D.; McKenzie, Brent S.; Vucic, Domagoj; Bingol, Baris 分享 收藏 分享 收藏 分享 收藏 分享 收藏 The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cellsCorzo, Cesar A.; Varfolomeev, Eugene; Setiadi, A. Francesca; Francis, Ross; Klabunde, Sha; Senger, Kate; Sujatha-Bhaskar, Swathi; Drobnick, Joy; Do, Steven; Suto, Eric; Huang, Zhiyu; Eastham-Anderson, Jeffrey; Katewa, Arna; Pang, Jodie; Domeyer, Melanie; Dela Cruz, Christopher; Paler-Martinez, Andres; Lau, Vivian W. C.; Hadadianpour, Azadeh; Ramirez-Carrozi, Vladimir; Sun, Yonglian; Bao, Katherine; Xu, Daqi; Hunley, Emily; Brightbill, Hans D.; Warming, Soren; Roose-Girma, Merone; Wong, Alfred; Tam, Lucinda; Emson, Claire L.; Crawford, James J.; Young, Wendy B.; Pappu, Rajita; McKenzie, Brent S.; Asghari, Vida; Vucic, Domagoj; Hackney, Jason A.; Austin, Cary D.; Lee, Wyne P.; Lekkerkerker, Annemarie; Ghilardi, Nico; Bryan, Marian C.; Kiefer, James R.; Townsend, Michael J.; Zarrin, Ali A. 分享 收藏 RIP1 kinase activity is critical for skin inflammation but not for viral propagationWebster, Joshua D.; Kwon, Youngsu C.; Park, Summer; Zhang, Hua; Corr, Nick; Ljumanovic, Nina; Adedeji, Adeyemi O.; Varfolomeev, Eugene; Goncharov, Tatiana; Preston, Jessica; Santagostino, Sara F.; Patel, Snahel; Xu, Min; Maher, Jonathan; McKenzie, Brent S.; Vucic, Domagoj 分享 收藏 The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxinsSuryamohan, Kushal; Krishnankutty, Sajesh P.; Guillory, Joseph; Jevit, Matthew; Schroeder, Markus S.; Wu, Meng; Kuriakose, Boney; Mathew, Oommen K.; Perumal, Rajadurai C.; Koludarov, Ivan; Goldstein, Leonard D.; Senger, Kate; Dixon, Mandumpala Davis; Velayutham, Dinesh; Vargas, Derek; Chaudhuri, Subhra; Muraleedharan, Megha; Goel, Ridhi; Chen, Ying-Jiun J.; Ratan, Aakrosh; Liu, Peter; Faherty, Brendan; de la Rosa, Guillermo; Shibata, Hiroki; Baca, Miriam; Sagolla, Meredith; Ziai, James; Wright, Gus A.; Vucic, Domagoj; Mohan, Sangeetha; Antony, Aju; Stinson, Jeremy; Kirkpatrick, Donald S.; Hannoush, Rami N.; Durinck, Steffen; Modrusan, Zora; Stawiski, Eric W.; Wiley, Kristen; Raudsepp, Terje; Kini, R. Manjunatha; Zachariah, Arun; Seshagiri, Somasekar 分享 收藏 
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