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P

Paul A. Johnston

university of pittsburgh

H指数:42

被引数:6,867

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Development, Optimization, and Validation of a TGF-β1-induced Common Mediator Smad4 Nuclear Translocation High Content Imaging Assay

TGF-β1诱导的通用中介分子Smad4核转位高内涵成像检测方法的开发、优化与验证

IF2.7

2026-10-210

OA

Optimization and calibration of 384-well kinetic Ca2+mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1

384孔动力学Ca2+动员实验的优化与校准，用于人类瞬时受体电位阳离子通道TRPM8、TRPV1和TRPA1

IF2.7

2025-01-010

OAAI

Subcutaneous administration of a novel TRPM8 antagonist reverses cold hypersensitivity while attenuating the drop in core body temperature

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2024-05-241

OA

Selecting a minimal set of androgen receptor assays for screening chemicals

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2020-11-0116

OAAI

Three dimensional engineered models to study hypoxia biology in breast cancer

IF10.1

2020-10-0121

OAAI

Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

FRONTIERS IN CHEMISTRY

IF4.2

2019-11-289

OAAI

Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules

MOLECULAR CANCER THERAPEUTICS

IF5.5

2017-10-0218

OAAI

Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone

IF3.3

2017-07-2419

OAAI

Toxicity, bioavailability, pharmacokinetics, tissue distribution and metabolism of a novel small molecule inhibitor of IL-6-induced STAT3 activation

CANCER RESEARCH

IF16.6

2016-07-150

PRE

Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-06-0224

OAAI

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2015-06-0138

PREAI

Use of an electronic alert to identify patients with acute kidney injury

CLINICAL MEDICINE

IF3.9

2014-02-0136

OAAI

Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in southwest England: A case-control study

JOURNAL OF MEDICAL VIROLOGY

IF4.6

2012-11-2034

PREAI

Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype

MOLECULAR CANCER THERAPEUTICS

IF5.5

2012-08-0827

OAAI

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents-real hits or promiscuous artifacts?

CURRENT OPINION IN CHEMICAL BIOLOGY

IF6.1

2011-02-0178

OAAI

Development and optimization of high-throughput in vitro protein phosphatase screening assays

NATURE PROTOCOLS

IF16

2007-05-0362

OAAI

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors

丝裂原活化蛋白激酶磷酸酶抑制剂聚焦文库的合成及生物活性

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2007-02-1218

PREAI

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites

MOLECULAR CANCER THERAPEUTICS

IF5.5

2005-05-16223

PRE

Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2005-04-0170

OAAI

Cellular platforms for HTS: three case studies

DRUG DISCOVERY TODAY

IF7.5

2002-03-01140

PREAI