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G

Graeme R. Robb

AstraZeneca
H指数:25
被引数:2,055

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Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470; an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation

利用人体剂量预测指标推动AZD3470的发现；一种处于临床评价阶段的MTA协同PRMT5抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-05-220
PRE
James M. Smith; Bernard Barlaam; David Beattie; Lauren Bradshaw; Ho Man Chan; Sophie L. Cooke; Anna Cronin; Iain Cumming; Emma Dean; Judit É. Debreczeni; Iván del Barco Barrantes; Douglas Ferguson; Davide Gianni; Michael Grondine; James T. Lynch; Lisa McWilliams; Shaun Moore; Piotr Raubo; Yang Qu; Graeme R. Robb; Lixiang Tan; Jelena Urosevic; Mercedes Vazquez-Chantada; Pingping Wang
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-120
PRE
Quinn, Taylor R.; Giblin, Kathryn A.; Thomson, Clare; Boerth, Jeffrey A.; Bommakanti, Gayathri; Braybrooke, Erin; Chan, Christina; Chinn, Alex J.; Code, Erin; Cui, Caifeng; Fan, Yukai; Grimster, Neil P.; Kohara, Keishi; Lamb, Michelle L.; Ma, Lina; Mfuh, Adelphe M.; Robb, Graeme R.; Robbins, Kevin J.; Schimpl, Marianne; Tang, Haoran; Ware, Jamie; Wrigley, Gail L.; Xue, Lin; Zhang, Yun; Zhu, Huimin; Hughes, Samantha J.
Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-07-310
PRE
Smith, James M.; Barlaam, Bernard; Beattie, David; Bradshaw, Lauren; Chan, Ho Man; Chiarparin, Elisabetta; Collingwood, Olga; Cooke, Sophie L.; Cronin, Anna; Cumming, Iain; Dean, Emma; Debreczeni, Judit E.; del Barco Barrantes, Ivan; Diene, Coura; Gianni, Davide; Guerot, Carine; Guo, Xiaoxiao; Guven, Sinem; Hayhow, Thomas G.; Hong, Ted; Kemmitt, Paul D.; Lamont, Gillian M.; Lamont, Scott; Lynch, James T.; McWilliams, Lisa; Moore, Shaun; Raubo, Piotr; Robb, Graeme R.; Robinson, James; Scott, James S.; Srinivasan, Bharath; Steward, Oliver; Stubbs, Christopher J.; Syson, Karl; Tan, Lixiang; Turner, Oliver; Underwood, Elizabeth; Urosevic, Jelena; Vazquez-Chantada, Mercedes; Whittaker, Amy L.; Wilson, David M.; Winter-Holt, Jon J.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-03-113
PRE
Atkinson, Stephen J.; Bagal, Sharan K.; Argyrou, Argyrides; Askin, Sean; Cheung, Tony; Chiarparin, Elisabetta; Coen, Muireann; Collie, Iain T.; Dale, Ian L.; De Fusco, Claudia; Dillman, Keith; Evans, Laura; Feron, Lyman J.; Foster, Alison J.; Grondine, Michael; Kantae, Vasudev; Lamont, Gillian M.; Lamont, Scott; Lynch, James T.; Lill, Sten Nilsson; Robb, Graeme R.; Saeh, Jamal; Schimpl, Marianne; Scott, James S.; Smith, James; Srinivasan, Bharath; Tentarelli, Sharon; Vazquez-Chantada, Mercedes; Wagner, David; Walsh, Jarrod J.; Watson, David; Williamson, Beth
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-02-024
PRE
Pike, Kurt G.; Hunt, Thomas A.; Barlaam, Bernard; Benstead, David; Cadogan, Elaine; Chen, Kan; Cook, Calum R.; Colclough, Nicola; Deng, Chao; Durant, Stephen T.; Eatherton, Andrew; Goldberg, Kristin; Johnstro''m, Peter; Liu, Libin; Liu, Zhaoqun; Nissink, J. Willem M.; Pang, Chengling; Pass, Martin; Robb, Graeme R.; Roberts, Caroline; Schou, Magnus; Steward, Oliver; Sykes, Andy; Yan, Yumei; Zhai, Baochang; Zheng, Li
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-163
PRE
Mfuh, Adelphe M.; Boerth, Jeffrey A.; Bommakanti, Gayathri; Chan, Christina; Chinn, Alex J.; Code, Erin; Fricke, Patrick J.; Giblin, Kathryn A.; Gohlke, Andrea; Hansel, Catherine; Hariparsad, Niresh; Hughes, Samantha J.; Jin, Meizhong; Kantae, Vasudev; Kavanagh, Stefan L.; Lamb, Michelle L.; Lane, Jordan; Moore, Rachel; Puri, Taranee; Quinn, Taylor R.; Reddy, Iswarya; Robb, Graeme R.; Robbins, Kevin J.; Rodrigo, Miguel Gancedo; Schimpl, Marianne; Singh, Baljinder; Singh, Meha; Tang, Haoran; Thomson, Clare; Walsh, Jarrod J.; Ware, Jamie; Watson, Iain D. G.; Ye, Min-Wei; Wrigley, Gail L.; Zhang, Andrew X.; Zhang, Yun; Grimster, Neil P.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

AZD4747的发现，这是一种有效且选择性的突变体GTPase KRASG12C抑制剂，具有明显的中枢神经系统穿透性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-0311
PRE
Kettle, Jason G.; Bagal, Sharan K.; Barratt, Derek; Bodnarchuk, Michael S.; Boyd, Scott; Braybrooke, Erin; Breed, Jason; Cassar, Doyle J.; Cosulich, Sabina; Davies, Michael; Davies, Nichola L.; Deng, Chao; Eatherton, Andrew; Evans, Laura; Feron, Lyman J.; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Gonzalez, Miguel A. Cortes; Guerot, Carine; Haider, Afreen; Harlfinger, Stephanie; Howells, Rachel; Jackson, Anne; Johnstrom, Peter; Kemmitt, Paul D.; Koers, Alex; Kondrashov, Mikhail; Lamont, Gillian M.; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Mylrea, Megan; Nash, Samuel; Niedbala, Michael J.; Peter, Alison; Phillips, Christopher; Pike, Kurt; Raubo, Piotr; Robb, Graeme R.; Ross, Sarah; Sanders, Matthew G.; Schou, Magnus; Simpson, Iain; Steward, Oliver
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors

嘧啶并吡啶酮系列IRAK4抑制剂的鉴定和优化

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2022-06-012
PRE
Cumming, Iain A.; Degorce, Sebastien L.; Aagaard, Anna; Braybrooke, Erin L.; Davies, Nichola L.; Diene, Coura R.; Eatherton, Andrew J.; Felstead, Hannah R.; Groombridge, Sam D.; Lenz, Eva M.; Li, Yunxia; Nai, Youfeng; Pearson, Stuart; Robb, Graeme R.; Scott, James S.; Steward, Oliver R.; Wu, Chengyan; Xue, Yafeng; Zhang, Lanping; Zhang, Yanxiu
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C

突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-2637
PRE
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-04-2628
OAAI
De Fusco, Claudia; Schimpl, Marianne; Borjesson, Ulf; Cheung, Tony; Collie, Iain; Evans, Laura; Narasimhan, Priyanka; Stubbs, Christopher; Vazquez-Chantada, Mercedes; Wagner, David J.; Grondine, Michael; Sanders, Matthew G.; Tentarelli, Sharon; Underwood, Elizabeth; Argyrou, Argyrides; Smith, James M.; Lynch, James T.; Chiarparin, Elisabetta; Robb, Graeme; Bagal, Sharan K.; Scott, James S.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2020-12-014
PREAI
Degorce, Sebastien L.; Aagaard, Anna; Anjum, Rana; Cumming, Iain A.; Diene, Coura R.; Fallan, Charlene; Johnson, Tony; Leuchowius, Karl-Johan; Orton, Alexandra L.; Pearson, Stuart; Robb, Graeme R.; Rosen, Alan; Scarfe, Graeme B.; Scott, James S.; Smith, James M.; Steward, Oliver R.; Terstiege, Ina; Tucker, Michael J.; Turner, Paul; Wilkinson, Stephen D.; Wrigley, Gail L.; Xue, Yafeng
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-0560
PREAI
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
ACS CHEMICAL BIOLOGY
IF3.8
2018-10-17120
OAAI
McCoull, William; Cheung, Tony; Anderson, Erica; Barton, Peter; Burgess, Jonathan; Byth, Kate; Cao, Qing; Castald, M. Paola; Chen, Huawei; Chiarparin, Elisabetta; Carbajo, Rodrigo J.; Code, Erin; Cowan, Suzanna; Davey, Paul R.; Ferguson, Andrew D.; Fillery, Shaun; Fuller, Nathan O.; Gao, Ning; Hargreaves, David; Howard, Martin R.; Hu, Jun; Kawatkar, Aarti; Kemmitt, Paul D.; Leo, Elisabetta; Molina, Daniel M.; O'Conne', Nichole; Petteruti, Philip; Rasmusson, Timothy; Raubo, Piotr; Rawlins, Philip B.; Ricchiuto, Piero; Robb, Graeme R.; Schenone, Monica; Waring, Michael J.; Zinda, Michael; Fawell, Stephen; Wilson, David M.

研究方向

暂未获取到该数据
P
Piotr Raubo
H 指数:23论文数:85被引数:1,357
J
James S. Scott
H 指数:51论文数:350被引数:8,539
P
Paul D. Kemmitt
H 指数:20论文数:94被引数:1,881
R
Rodrigo J. Carbajo
H 指数:30论文数:108被引数:2,576
W
William McCoull
H 指数:24论文数:87被引数:2,114
B
Bernard Barlaam
H 指数:24论文数:100被引数:1,909
N
Nichola L. Davies
H 指数:16论文数:29被引数:1,201
E
Elisabetta Chiarparin
H 指数:32论文数:97被引数:3,107
M
Michael J. Waring
H 指数:65论文数:406被引数:1.9万
K
Kurt G. Pike
H 指数:24论文数:94被引数:2,075