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K

Kurt G. Pike

AstraZeneca
H指数:24
被引数:2,060

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Achieving human brain exposure with the oral ataxia-telangiectasia mutated kinase inhibitor AZD1390, a substrate of aldehyde oxidase

通过口服A-T突变酶抑制剂AZD1390（醛氧化酶底物）实现人脑暴露。

Drug Metabolism and Disposition
IF4
2025-06-030
PRE
Nicola Colclough; Alexandra L. Orton; Scott Martin; Martin Wild; Venkatesh Pilla Reddy; Eva Lenz; Roshini Markandu; Joanne Wilson; Chunling Fan; Julian Potter; David Dai; Christina Chan; Jennie Roberts; Aixiang Xue; Petar Pop-Damkov; Andy Sykes; Barry Jones; Thomas A. Hunt; Kurt G. Pike; Dermot F. McGinnity
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-02-024
PRE
Pike, Kurt G.; Hunt, Thomas A.; Barlaam, Bernard; Benstead, David; Cadogan, Elaine; Chen, Kan; Cook, Calum R.; Colclough, Nicola; Deng, Chao; Durant, Stephen T.; Eatherton, Andrew; Goldberg, Kristin; Johnstro''m, Peter; Liu, Libin; Liu, Zhaoqun; Nissink, J. Willem M.; Pang, Chengling; Pass, Martin; Robb, Graeme R.; Roberts, Caroline; Schou, Magnus; Steward, Oliver; Sykes, Andy; Yan, Yumei; Zhai, Baochang; Zheng, Li
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

AZD4747的发现，这是一种有效且选择性的突变体GTPase KRASG12C抑制剂，具有明显的中枢神经系统穿透性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-0311
PRE
Kettle, Jason G.; Bagal, Sharan K.; Barratt, Derek; Bodnarchuk, Michael S.; Boyd, Scott; Braybrooke, Erin; Breed, Jason; Cassar, Doyle J.; Cosulich, Sabina; Davies, Michael; Davies, Nichola L.; Deng, Chao; Eatherton, Andrew; Evans, Laura; Feron, Lyman J.; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Gonzalez, Miguel A. Cortes; Guerot, Carine; Haider, Afreen; Harlfinger, Stephanie; Howells, Rachel; Jackson, Anne; Johnstrom, Peter; Kemmitt, Paul D.; Koers, Alex; Kondrashov, Mikhail; Lamont, Gillian M.; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Mylrea, Megan; Nash, Samuel; Niedbala, Michael J.; Peter, Alison; Phillips, Christopher; Pike, Kurt; Raubo, Piotr; Robb, Graeme R.; Ross, Sarah; Sanders, Matthew G.; Schou, Magnus; Simpson, Iain; Steward, Oliver
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-11-2223
PREAI
Bagal, Sharan K.; Gregson, Clare; O' Donovan, Daniel H.; Pike, Kurt G.; Bloecher, Andrew; Barton, Peter; Borodovsky, Alexandra; Code, Erin; Fillery, Shaun M.; Hsu, Jessie Hao-Ru; Kawatkar, Sameer P.; Li, Chengzhi; Longmire, David; Nai, Youfeng; Nash, Samuel C.; Pike, Andrew; Robinson, James; Read, Jon A.; Rawlins, Phillip B.; Shen, Minhui; Tang, Jia; Wang, Peng; Woods, Haley; Williamson, Beth
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-10-1415
PREAI
Barlaam, Bernard; De Savi, Chris; Dishington, Allan; Drew, Lisa; Ferguson, Andrew D.; Ferguson, Douglas; Gu, Chungang; Hande, Sudhir; Hassall, Lorraine; Hawkins, Janet; Hird, Alexander W.; Holmes, Jane; Lamb, Michelle L.; Lister, Andrew S.; McGuire, Thomas M.; Moore, Jane E.; O'Connell, Nichole; Patel, Anil; Pike, Kurt G.; Sarkar, Ujjal; Shao, Wenlin; Stead, Darren; Varnes, Jeffrey G.; Vasbinder, Melissa M.; Wang, Lei; Wu, Liangwei; Xue, Lin; Yang, Bin; Yao, Tieguang
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-12-1165
PREAI
Barlaam, Bernard; Casella, Robert; Cidado, Justin; Cook, Calum; De Savi, Chris; Dishington, Allan; Donald, Craig S.; Drew, Lisa; Ferguson, Andrew D.; Ferguson, Douglas; Glossop, Steve; Grebe, Tyler; Gu, Chungang; Hande, Sudhir; Hawkins, Janet; Hird, Alexander W.; Holmes, Jane; Horstick, James; Jiang, Yun; Lamb, Michelle L.; McGuire, Thomas M.; Moore, Jane E.; O'Connell, Nichole; Pike, Andy; Pike, Kurt G.; Proia, Theresa; Roberts, Bryan; San Martin, Maryann; Sarkar, Ujjal; Shao, Wenlin; Stead, Darren; Sumner, Neil; Thakur, Kumar; Vasbinder, Melissa M.; Varnes, Jeffrey G.; Wang, Jianyan; Wang, Lei; Wu, Dedong; Wu, Liangwei; Yang, Bin; Yao, Tieguang
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
MOLECULAR CANCER THERAPEUTICS
IF5.5
2020-01-03123
OAAI
Riches, Lucy C.; Trinidad, Antonio G.; Hughes, Gareth; Jones, Gemma N.; Hughes, Adina M.; Thomason, Andrew G.; Gavine, Paul; Cui, Andy; Ling, Stephanie; Stott, Jonathan; Clark, Roger; Peel, Samantha; Gill, Pendeep; Goodwin, Louise M.; Smith, Aaron; Pike, Kurt G.; Barlaam, Bernard; Pass, Martin; O'Connor, Mark J.; Smith, Graeme; Cadogan, Elaine B.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-07-3154
OAAI
Karlin, Jeremy; Allen, Jasmine; Ahmad, Syed F.; Hughes, Gareth; Sheridan, Victoria; Odedra, Rajesh; Farrington, Paul; Cadogan, Elaine B.; Riches, Lucy C.; Garcia-Trinidad, Antonio; Thomason, Andrew G.; Patel, Bhavika; Vincent, Jennifer; Lau, Alan; Pike, Kurt G.; Hunt, Thomas A.; Sule, Amrita; Valerie, Nicholas C. K.; Biddlestone-Thorpe, Laura; Kahn, Jenna; Beckta, Jason M.; Mukhopadhyay, Nitai; Barlaam, Bernard; Degorce, Sebastien L.; Kettle, Jason; Colclough, Nicola; Wilson, Joanne; Smith, Aaron; Barrett, Ian P.; Zheng, Li; Zhang, Tianwei; Wang, Yingchun; Chen, Kan; Pass, Martin; Durant, Stephen T.; Valerie, Kristoffer
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2018-07-1326
OAAI
Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Colclough, Nicola; Dishington, Allan; Durant, Stephen; Goldberg, Kristin; Hassall, Lorraine A.; Hughes, Gareth D.; MacFaul, Philip A.; McGuire, Thomas M.; Pass, Martin; Patel, Anil; Pearson, Stuart; Petersen, Jens; Pike, Kurt G.; Robb, Graeme; Stratton, Natalie; Xin, Guohong; Zhai, Baochang
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
SCIENCE ADVANCES
IF12.5
2018-06-01221
OAAI
Durant, Stephen T.; Zheng, Li; Wang, Yingchun; Chen, Kan; Zhang, Lingli; Zhang, Tianwei; Yang, Zhenfan; Riches, Lucy; Trinidad, Antonio G.; Fok, Jacqueline H. L.; Hunt, Tom; Pike, Kurt G.; Wilson, Joanne; Smith, Aaron; Colclough, Nicola; Reddy, Venkatesh Pilla; Sykes, Andrew; Janefeldt, Annika; Johnstrom, Peter; Varnas, Katarina; Takano, Akihiro; Ling, Stephanie; Orme, Jonathan; Stott, Jonathan; Roberts, Caroline; Barrett, Ian; Jones, Gemma; Roudier, Martine; Pierce, Andrew; Allen, Jasmine; Kahn, Jenna; Sule, Amrita; Karlin, Jeremy; Cronin, Anna; Chapman, Melissa; Valerie, Kristoffer; Illingworth, Ruth; Pass, Martin
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-04-23101
OAAI
Pike, Kurt G.; Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Chen, Yingxue; Colclough, Nicola; Davies, Nichola L.; de-Almeida, Camila; Degorce, Sebastien L.; Didelot, Myriam; Dishington, Allan; Ducray, Richard; Durant, Stephen T.; Hassall, Lorraine A.; Holmes, Jane; Hughes, Gareth D.; MacFaul, Philip A.; Mulholland, Keith R.; McGuire, Thomas M.; Ouvry, Gilles; Pass, Martin; Robb, Graeme; Stratton, Natalie; Wang, Zhenhua; Wilson, Joanne; Zhai, Baochang; Zhao, Kang; Al-Huniti, Nidal
AZD1390, a potent and selective orally bioavailable blood-brain barrier-penetrant ATM inhibitor, radiosensitizes and improves survival of orthotopic glioma and metastatic brain tumor models
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-01-013
PRE
Durant, Steve T.; Pike, Kurt G.; Colclough, Nicola; Riches, Lucy; Garcia-Trinidad, Antonio; Hunt, Thomas; Ling, Stephanie; Stott, Jonathan; Barrett, Ian; Zheng, Li; Wang, Yingchun; Chen, Kan; Zhang, Tianwei; Reddy, Venkatesh Pilla; Sykes, Andrew; Johnstrom, Peter; Jones, Gemma; Pierce, Andrew; Karlin, Jeremy; Kahn, Jenna; Allen, Jasmine; Valerie, Kristoffer; Illingworth, Ruth; Pass, Martin
Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML
SCIENCE SIGNALING
IF6.6
2016-09-1357
OAAI
Morgado-Palacin, Isabel; Day, Amanda; Murga, Matilde; Lafarga, Vanesa; Elena Anton, Marta; Tubbs, Anthony; Chen, Hua-Tang; Ergen, Aysegul V.; Anderson, Rhonda; Bhandoola, Avinash; Pike, Kurt G.; Barlaam, Bernard; Cadogan, Elaine; Wang, Xi; Pierce, Andrew J.; Hubbard, Chad; Armstrong, Scott A.; Nussenzweig, Andre; Fernandez-Capetillo, Oscar

研究方向

暂未获取到该数据
B
Bernard Barlaam
H 指数:24论文数:100被引数:1,893
M
Martin Pass
H 指数:26论文数:189被引数:4,233
E
Elaine Cadogan
H 指数:26论文数:128被引数:2,860
N
Nicola Colclough
H 指数:24论文数:123被引数:3,013
S
Stephen T. Durant
H 指数:25论文数:109被引数:3,313
A
Allan Dishington
H 指数:14论文数:54被引数:663
K
Kristoffer Valerie
H 指数:67论文数:271被引数:1.3万
G
Graeme R. Robb
H 指数:25论文数:70被引数:2,043
J
Jeremy Karlin
H 指数:8论文数:40被引数:508
J
Joanne Wilson
H 指数:25论文数:203被引数:3,200