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R

Rachel Howells

chemistry, oncology r&d, astrazeneca, cambridge cb2 0aa, u.k.
H指数:14
被引数:913

个人简介

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荣誉奖项

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Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors

合成化学使一系列作为HPK1抑制剂的吡唑的发现和开发成为可能

RSC Med. Chem.
IF3.6
2025-08-140
PRE
Anthony J. Metrano; Lucas A. Morrill; Gayathri Bommakanti; Robert Casella; Steve Cook; Randolph A. Escobar; Kathryn A. Giblin; Eric Gosselin; Tyler Grebe; Niresh Hariparsad; Rachel Howells; Gillian M. Lamont; Deanna A. Mele; Alexander Pflug; Theresa A. Proia; Hadi Rezaei; Magdalena Richter; Ryan Richards; Maryann San Martin; Marianne Schimpl; Alwin G. Schuller; Li Sha; James E. Sheppeck, II; Kun Song; Haoran Tang; David J. Wagner; Jianyan Wang; Allan Wu; Dedong Wu; Ye Wu; Kevin Xu; Minwei Ye; Jason D. Shields; Neil P. Grimster
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor

吡嗪羧酰胺AZ3246的发现与优化：一种选择性HPK1抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-02-102
PRE
Shields, Jason D.; Baker, David; Balazs, Amber Y. S.; Bommakanti, Gayathri; Casella, Robert; Cao, Shenggen; Cook, Steve; Escobar, Randolph A.; Fawell, Stephen; Gibbons, Francis D.; Giblin, Kathryn A.; Goldberg, Frederick W.; Gosselin, Eric; Grebe, Tyler; Hariparsad, Niresh; Hatoum-Mokdad, Holia; Howells, Rachel; Hughes, Samantha J.; Jackson, Anne; Reddy, Iswarya Karapa; Kettle, Jason G.; Lamont, Gillian M.; Lamont, Scott; Li, Min; Lill, Sten O. Nilsson; Mele, Deanna A.; Metrano, Anthony J.; Mfuh, Adelphe M.; Morrill, Lucas A.; Peng, Bo; Pflug, Alexander; Proia, Theresa A.; Rezaei, Hadi; Richards, Ryan; Richter, Magdalena; Robbins, Kevin J.; San Martin, Maryann; Schimpl, Marianne; Schuller, Alwin G.; Sha, Li; Shen, Minhui; Sheppeck, James E.; Singh, Meha; Stokes, Stephen; Song, Kun; Sun, Yuanyuan; Tang, Haoran; Wagner, David J.; Wang, Jianyan; Wang, Yanjun; Wilson, David M.; Wu, Allan; Wu, Chengyan; Wu, Dedong; Wu, Ye; Xu, Kevin; Yang, Yue; Yao, Tieguang; Ye, Minwei; Zhang, Andrew X.; Zhang, Hui; Zhai, Xiang; Zhou, Yanxiao; Ziegler, Robert E.; Grimster, Neil P.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

AZD4747的发现，这是一种有效且选择性的突变体GTPase KRASG12C抑制剂，具有明显的中枢神经系统穿透性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-0311
PRE
Kettle, Jason G.; Bagal, Sharan K.; Barratt, Derek; Bodnarchuk, Michael S.; Boyd, Scott; Braybrooke, Erin; Breed, Jason; Cassar, Doyle J.; Cosulich, Sabina; Davies, Michael; Davies, Nichola L.; Deng, Chao; Eatherton, Andrew; Evans, Laura; Feron, Lyman J.; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Gonzalez, Miguel A. Cortes; Guerot, Carine; Haider, Afreen; Harlfinger, Stephanie; Howells, Rachel; Jackson, Anne; Johnstrom, Peter; Kemmitt, Paul D.; Koers, Alex; Kondrashov, Mikhail; Lamont, Gillian M.; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Mylrea, Megan; Nash, Samuel; Niedbala, Michael J.; Peter, Alison; Phillips, Christopher; Pike, Kurt; Raubo, Piotr; Robb, Graeme R.; Ross, Sarah; Sanders, Matthew G.; Schou, Magnus; Simpson, Iain; Steward, Oliver
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C

突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-2637
PRE
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-0560
PREAI
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-11-1150
PREAI
Ward, Richard A.; Anderton, Mark J.; Bethel, Paul; Breed, Jason; Cook, Calum; Davies, Emma J.; Dobson, Andrew; Dong, Zhiqiang; Fairley, Gary; Farrington, Paul; Feron, Lyman; Flemington, Vikki; Gibbons, Francis D.; Graham, Mark A.; Greenwood, Ryan; Hanson, Lyndsey; Hopcroft, Philip; Howells, Rachel; Hudson, Julian; James, Michael; Jones, Clifford D.; Jones, Christopher R.; Li, Yongchao; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; McCabe, James; McGuire, Thomas; Rawlins, Philip; Roberts, Karen; Sandin, Linda; Simpson, Iain; Swallow, Steve; Tang, Jia; Tomkinson, Gary; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang
Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome

AZD8421的发现：一种对其他CDK家族成员及人激酶组具有选择性的强效CDK2抑制剂

Journal of Medicinal Chemistry
IF6.8
0
PRE
Avipsa Ghosh; Afshan Ahmed; Konstantina Amoiradaki; Amber Y. S. Balazs; Bernard Barlaam; Michael Steven Bodnarchuk; Gavin W. Collie; Ian L. Dale; Christopher R. Denz; Lisa Drew; Scott D. Edmondson; Jun Fan; Stephen Fawell; Frederick W. Goldberg; Ariamala Gopalsamy; Michael Grondine; Grace Guo; Sudhir M. Hande; Holia Hatoum-Mokdad; Alexander W. Hird; Rachel Howells; Jessie Hao-Ru Hsu; Jessica Hudson; Anne Jackson; Michelle L. Lamb; Gillian M. Lamont; Scott Lamont; Phillip A. Lichtor; Lisa McWilliams; David Milne; Scott N. Mlynarski; Priyanka Narasimhan; Matthew F. Peters; Alexander Pflug; Hannah Kate Pollard; Meile Qin; Corinne Reimer; Kevin J. Robbins; James Robinson; Li Sha; Hongyao She; James E. Sheppeck II; Baljinder Singh; Kun Song; Qibin Su; Reem Telmesani; Scott Throner; Christina Vasalou; Lei Wang; Yanjun Wang; David M. Wilson; Poppy Winlow; Wenzhan Yang; Tieguang Yao; Yun Zhang; Zirong Zhang; Diana Zindel; Jeffrey W. Johannes

研究方向

暂未获取到该数据
G
Gillian M. Lamont
H 指数:16论文数:58被引数:1,630
F
Frederick W. Goldberg
H 指数:20论文数:71被引数:1,714
S
Scott G. Lamont
H 指数:19论文数:69被引数:1,704
M
Michael S. Bodnarchuk
H 指数:16论文数:40被引数:1,018
J
J. Breed
H 指数:40论文数:108被引数:4,792
J
Jason G. Kettle
H 指数:31论文数:163被引数:3,398
L
Lyman J. Feron
H 指数:12论文数:40被引数:1,051
A
Anne Jackson
H 指数:7论文数:15被引数:305
C
Christopher Phillips
H 指数:66论文数:317被引数:1.3万
L
Libin Liu
H 指数:26论文数:85被引数:3,432