未登录 Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1) Gilmore, John L.; Sheppeck, James E., II; Watterson, Scott H.; Hague, Lauren; Mukhopadhyay, Parag; Tebben, Andrew J.; Galena, Michael A.; Shen, Ding Ren; Yarde, Melissa; Cvijic, Mary Ellen; Borowski, Virna; Gillooly, Kathleen; Taylor, Tracy; McIntyre, Kim W.; Warrack, Bethanne; Levesque, Paul C.; Li, Julia P.; Cornelius, Georgia; D'Arienzo, Celia; Marino, Anthony; Balimane, Praveen; Salter-Cid, Luisa; Barrish, Joel C.; Pitts, William J.; Carter, Percy H.; Xie, Jenny; Dyckman, Alaric J. 分享 收藏
An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist Hou, Xiaoping; Zhu, Juliang; Chen, Bang-Chi; Watterson, Scott H.; Pitts, William J.; Dyckman, Alaric J.; Carter, Percy H.; Mathur, Arvind; Zhang, Huiping 分享 收藏
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series Watterson, Scott H.; Guo, Junqing; Spergel, SteiTe H.; Langevine, Charles M.; Moquin, Robert V.; Shen, Ding Ren; Yarde, Melissa; Cvijic, Mary Ellen; Banas, Dana; Liu, Richard; Suchard, Suzanne J.; Gillooly, Kathleen; Taylor, Tracy; Rex-Rabe, Sandra; Shuster, David J.; McIntyre, Kim W.; Cornelius, Georgia; D'Arienzo, Celia; Marino, Anthony; Balimane, Praveen; Warrack, Bethanne; Salter-Cid, Luisa; McKinnon, Murray; Barrish, Joel C.; Carter, Percy H.; Pitts, William J.; Xie, Jenny; Dyckman, Alaric J. 分享 收藏
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors Hart, Amy C.; Schroeder, Gretchen M.; Wan, Honghe; Grebinski, James; Inghrim, Jennifer; Kempson, James; Guo, Junqing; Pitts, William J.; Tokarski, John S.; Sack, John S.; Khan, Javed A.; Lippy, Jonathan; Lorenz, Matthew V.; You, Dan; McDevitt, Theresa; Vuppugalla, Ragini; Zhang, Yueping; Lombardo, Louis J.; Trainor, George L.; Purandare, Ashok V. 分享 收藏
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain T淋巴细胞中酪氨酸激酶2介导的信号转导被其假激酶结构域的药理稳定所阻断 Tokarski, John S.; Zupa-Fernandez, Adriana; Tredup, Jeffrey A.; Pike, Kristen; Chang, ChiehYing; Xie, Dianlin; Cheng, Lihong; Pedicord, Donna; Muckelbauer, Jodi; Johnson, Stephen R.; Wu, Sophie; Edavettal, Suzanne C.; Hong, Yang; Witmer, Mark R.; Elkin, Lisa L.; Blat, Yuval; Pitts, William J.; Weinstein, David S.; Burke, James R. 分享 收藏
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Periodic, Partial Inhibition of IκB Kinase β-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis Gillooly, Kathleen M.; Pattoli, Mark A.; Taylor, Tracy L.; Chen, Laishun; Cheng, Lihong; Gregor, Kurt R.; Whitney, Gena S.; Susulic, Vojkan; Watterson, Scott H.; Kempson, James; Pitts, William J.; Booth-Lute, Hollie; Yang, Guchen; Davies, Paul; Kukral, Daniel W.; Strnad, Joann; McIntyre, Kim W.; Darienzo, Celia J.; Salter-Cid, Luisa; Yang, Zheng; Wang-Iverson, David B.; Burke, James R. 分享 收藏
Novel Tricyclic Inhibitors of IκB Kinase Kempson, James; Spergel, Steven H.; Guo, Junqing; Quesnelle, Claude; Gill, Patrice; Belanger, Dominique; Dyckman, Alaric J.; Li, Tianle; Watterson, Scott H.; Langevine, Charles M.; Das, Jagabandhu; Moquin, Robert V.; Furch, Joseph A.; Marinier, Anne; Dodier, Marco; Martel, Alain; Nirschl, David; Van Kirk, Katy; Burke, James R.; Pattoli, Mark A.; Gillooly, Kathleen; McIntyre, Kim W.; Chen, Laishun; Yang, Zheng; Marathe, Punit H.; Wang-Iverson, David; Dodd, John H.; McKinnon, Murray; Barrish, Joel C.; Pitts, William J. 分享 收藏
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A modified approach to 2-(N-aryl)-1,3-oxazoles:: Application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues Dhar, TGM; Guo, JQ; Shen, ZQ; Pitts, WJ; Gu, HH; Chen, BC; Zhao, RL; Bednarz, MS; Iwanowicz, EJ 分享 收藏
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Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]-amino]-5-oxazolyl]phenyl]-N-methyl-4-morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity Dhar, TGM; Shen, ZQ; Guo, JQ; Liu, CJ; Watterson, SH; Gu, HH; Pitts, WJ; Fleener, CA; Rouleau, KA; Sherbina, NZ; McIntyre, KW; Witmer, MR; Tredup, JA; Chen, BC; Zhao, RL; Bednarz, MS; Cheney, DL; MacMaster, JF; Miller, LM; Berry, KK; Harper, TW; Barrish, JC; Hollenbaugh, DL; Iwanowicz, EJ 分享 收藏
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Isoxazolines as potent antagonists of the integrin αvβ3 Pitts, WJ; Wityak, J; Smallheer, JM; Tobin, AE; Jetter, JW; Buynitsky, JS; Harlow, PP; Solomon, KA; Corjay, MH; Mousa, SA; Wexler, RR; Jadhav, PK 分享 收藏
Identification of a novel inhibitor of mitogen-activated protein kinase kinase 一种新型丝裂原活化蛋白激酶激酶抑制剂的鉴定 Favata, MF; Horiuchi, KY; Manos, EJ; Daulerio, AJ; Stradley, DA; Feeser, WS; Van Dyk, DE; Pitts, WJ; Earl, RA; Hobbs, F; Copeland, RA; Magolda, RL; Scherle, PA; Trzaskos, JM 分享 收藏
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