André G. Tempone - Publications, H-index & Citations

André G. Tempone

pathophysiology laboratory

38H指数

157论文数

3.9K被引数

收录论文 40

发表时间

Computational and experimental studies to discover a promising lead compound, chemically related to natural acetylene acetogenins from Porcelia macrocarpa, against amastigotes of Leishmania (L.) infantum 计算和实验研究以发现一种有前景的先导化合物，该化合物与Porcelia macrocarpa天然乙炔乙酰基乙烷类化合物化学相关，可对抗利什曼原虫（L.）infantum的鞭毛体。

Journal of Computer-Aided Molecular Design

IF3.1

2025-10-04

PREAI

João Pedro P. Encide; Ivanildo A. de Brito; Maiara Amaral; Andre G. Tempone; João Henrique G. Lago; Kathia M. Honorio

Multitarget anti-parasitic activities of isoquinoline alkaloids isolated from Hippeastrum aulicum (Amaryllidaceae)

PHYTOMEDICINE

IF8.3

2024-06-01

PREAI

Bessa, Carliani Dal Piero Betzel; Feu, Amanda Eiriz; de Menezes, Renata Priscila Barros; Scotti, Marcus Tullius; Lima, Julia Maria Godoi; Lima, Marta Lopes; Tempone, Andre Gustavo; de Andrade, Jean Paulo; Bastida, Jaume; Borges, Warley de Souza

Evaluation of Anti-Trypanosoma cruzi Activity of Chemical Constituents from Baccharis sphenophylla Isolated Using High-Performance Countercurrent Chromatography

MOLECULES

IF4.6

2023-12-30

OAAI

Silva, Matheus L.; Sales, Felipe S.; Levatti, Erica V. C.; Antar, Guilherme M.; Tempone, Andre G.; Lago, Joao Henrique G.; Jerz, Gerold

Effect of partial O-methylation in dehydrodieugenol on its antitrypanosomal activity-correlation with the toxicity using cell membrane models

BIOPHYSICAL CHEMISTRY

IF2.2

2023-05-01

PREAI

Goncalves, Giulia Elisa G.; Oliveira, Samuel; Gomes, Kaio de Souza; Costa-Silva, Thais Alves; Tempone, Andre Gustavo; Lago, Joao Henrique Ghilardi; Caseli, Luciano

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2022-04-01

OAAI

Varela, Marina T.; Amaral, Maiara; Romanelli, Maiara M.; Levatti, Erica V. de Castro; Tempone, Andre G.; Fernandes, Joao Paulo S.

Evaluation of antileishmanial potential of the antidepressant escitalopram in Leishmania infantum

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2022-02-01

PREAI

Lima, Marta Lopes; Amaral, Maiara; Treiger Borborema, Samanta Etel; Tempone, Andre Gustavo

Antileishmanial Effects of Acetylene Acetogenins from Seeds of Porcelia macrocarpa (Warm.) RE Fries (Annonaceae) and Semisynthetic Derivatives

MOLECULES

IF4.6

2022-01-28

OAAI

Brito, Ivanildo A.; Thevenard, Fernanda; Costa-Silva, Thais A.; Oliveira, Samuel S.; Cunha, Rodrigo L. O. R.; de Oliveira, Emerson A.; Sartorelli, Patricia; Guadagnin, Rafael C.; Romanelli, Maiara M.; Tempone, Andre G.; Lago, Joao Henrique G.

Ent-kaurane diterpenes isolated from n-hexane extract of Baccharis sphenophylla by bioactivity-guided fractionation target the acidocalcisomes in Trypanosoma cruzi

PHYTOMEDICINE

IF8.3

2021-12-01

PREAI

da Costa-Silva, Thais A.; Silva, Matheus L.; Antar, Guilherme M.; Tempone, Andre G.; Lago, Joao Henrique G.

Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A 改善激发天然产物的药物相似性-通过licarin A的半合成和简化类似物评估对克氏锥虫的抗寄生虫活性

SCIENTIFIC REPORTS

IF3.9

2020-03-25

OAAI

Morais, Thiago R.; Alves Conserva, Geanne A.; Varela, Marina T.; Costa-Silva, Thais A.; Thevenard, Fernanda; Ponci, Vitor; Fortuna, Ana; Falcao, Amilcar C.; Tempone, Andre G.; Fernandes, Joao Paulo S.; Lago, Joao Henrique G.

Electrospray mass-spectrometry guided target isolation of neolignans from Nectandra leucantha (Lauraceae) by high performance- and spiral-coil countercurrent chromatography

JOURNAL OF CHROMATOGRAPHY A

IF4

2019-12-01

PREAI

Grecco, Simone dos Santos; Letsyo, Emmanuel; Tempone, Andre Gustavo; Ghilardi Lago, Joao Henrique; Jerz, Gerold

Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2019-08-01

OAAI

Ferreira, Daiane D.; Sousa, Fernanda S.; Costa-Silva, Thais A.; Reimao, Juliana Q.; Torrecilhas, Ana C.; Johns, Deidre M.; Sear, Claire E.; Honorio, Kathia M.; Lago, Joao Henrique G.; Anderson, Edward A.; Tempone, Andre G.

Antitrypanosomal Activity of Acetogenins Isolated from the Seeds of Porcelia macrocarpa Is Associated with Alterations in Both Plasma Membrane Electric Potential and Mitochondrial Membrane Potential

JOURNAL OF NATURAL PRODUCTS

IF3.6

2019-05-02

PREAI

Oliveira, Emerson A.; Brito, Ivanildo A.; Lima, Marta L.; Romanelli, Maiara; Moreira-Filho, Jose T.; Neves, Bruno J.; Andrade, Carolina H.; Sartorelli, Patricia; Tempone, Andre G.; Costa-Silva, Thais A.; Lago, Joao Henrique G.

A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division

SCIENTIFIC REPORTS

IF3.9

2019-04-16

OAAI

Amaral, Maiara; de Sousa, Fernanda S.; Silva, Thais A. Costa; Junior, Andres Jimenez G.; Taniwaki, Noemi N.; Johns, Deid Re M.; Lago, Joao Henrique G.; Anderson, Edward A.; Tempone, Andre G.

Butenolides from Nectandra oppositifolia (Lauraceae) displayed anti-Trypanosoma cruzi activity via deregulation of mitochondria

PHYTOMEDICINE

IF8.3

2019-02-01

PREAI

Alves Conserva, Geanne A.; da Costa-Silva, Thais A.; Amaral, Maiara; Antar, Guilherme M.; Neves, Bruno J.; Andrade, Carolina H.; Tempone, Andre G.; Lago, Joao Henrique G.

Molecular Basis of the Leishmanicidal Activity of the Antidepressant Sertraline as a Drug Repurposing Candidate

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-12-01

OAAI

Lima, Marta L.; Abengozar, Maria A.; Nacher-Vazquez, Montserrat; Martinez-Alcazar, Maria P.; Barbas, Coral; Tempone, Andre G.; Lopez-Gonzalvez, Angeles; Rivas, Luis

Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2018-09-01

PREAI

Varela, Marina T.; Romaneli, Maiara M.; Lima, Marta L.; Borborema, Samanta E. T.; Tempone, Andre G.; Fernandes, Joao P. S.

Pharmacokinetic of meglumine antimoniate encapsulated in phosphatidylserine-liposomes in mice model: A candidate formulation for visceral leishmaniasis

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2018-07-01

PREAI

Treiger Borborema, Samanta Etel; Osso Junior, Joao Alberto; Tempone, Andre Gustavo; de Andrade Junior, Heitor Franco; do Nascimento, Nanci

Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-10-01

OAAI

Tempone, Andre Gustavo; Ferreira, Daiane Dias; Lima, Marta Lopes; Costa Silva, Thais Alves; Borborema, Samanta E. T.; Reimao, Juliana Quero; Galuppo, Mariana K.; Guerra, Juliana Mariotti; Russell, Angelie J.; Wynne, Graham M.; Lai, Roy Y. L.; Cadelis, Melissa M.; Copp, Brent R.

New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2017-05-03

PREAI

Varela, Marina T.; Lima, Marta L.; Galuppo, Mariana K.; Tempone, Andre G.; de Oliveira, Alberto; Lago, Joao Henrique G.; Fernandes, Joao Paulo S.

Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones

MOLECULES

IF4.6

2017-04-25

OAAI

Wulsten, Imke E.; Costa-Silva, Thais A.; Mesquita, Juliana T.; Lima, Marta L.; Galuppo, Mariana K.; Taniwaki, Noemi N.; Borborema, Samanta E. T.; Da Costa, Fernando B.; Schmidt, Thomas J.; Tempone, Andre G.

研究方向