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C

Christian Landles

university college london
H指数:23
被引数:4,417

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Cas9 nickase–mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington’s disease mouse model

Cas9 nuclease介导的CAG/CTG重复序列缩短与亨廷顿病小鼠模型表型改善相关

Science Translational Medicine
IF14.6
2026-10-210
PRE
Alvaro Murillo; Melanie Alpaugh; Ruban Rex Peter Durairaj; Emma L. Randall; Meghan Larin; Laura Heraty; Alys N. Aston; Alysha S. Taylor; Alex Mas Monteys; Nina Stöberl; Aeverie E. R. Heuchan; Pascale Aeschlimann; Kyle Fears; Christian Landles; Georgina F. Osborne; Antoine Mangin; Soumyasree Bhattacharyya; Emmanouil Metzakopian; Nicholas D. Allen; Jack Puymirat; Gillian P. Bates; Beverly L. Davidson; Francesca Cicchetti; Mariah J. Lelos; Vincent Dion
Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington’s disease pathogenesis in mice

通过RNAi阻断体细胞重复序列扩增和降低亨廷蛋白协同减轻亨廷顿病在小鼠中的病理发生

Science Translational Medicine
IF14.6
2026-08-120
PRE
Jillian Belgrad; Ashley Summers; Christian Landles; Jonathan R. Greene; Samuel Hildebrand; Emily Knox; Ellen Sapp; Nozomi Yamada; Raymond Furgal; Rachael Miller; Georgina F. Osborne; Kathryn Chase; Eric Luu; Jason Freedman; Brianna Bramato; Nicholas McHugh; Israel Nnah; Vicky Benoit; Daniel O’Reilly; Paul Greer; Gillian P. Bates; Thomas F. Vogt; Ramee Lee; David Howland; Marian DiFiglia; Neil Aronin; Anastasia Khvorova
Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7

人类特有序列特征通过剪接因子SRSF7促进HTT外显子1的毒性错位处理

Nature Communications
IF15.7
2026-07-310
OA
Camilla Maffezzini; Raffaele Iennaco; Andrea Scolz; Simone Maestri; Christian Landles; Georgina F. Osborne; Marta M. Bronzini; Camilla Trovesi; Thomas Carzaniga; Luca Casiraghi; Jimena Quiros Ramirez; Thomas F. Vogt; Dan P. Felsenfeld; Tommaso Bellini; Chiara Zuccato; Gillian P. Bates; Elena Cattaneo
Molecular features of a Huntington's disease knock-in minipig

亨廷顿病基因敲入小型猪的分子特征

Disease Models & Mechanisms
IF3.3
2026-05-010
PRE
Kolesnikova, Anastasiia; Sathasivam, Kirupa; Tusi, Solaleh Khoramian; Landles, Christian; Osborne, Georgina F.; Kovalenko, Marina; Gillis, Tammy; Kamenna, Eva; Sekac, David; Nguyen, Duong The; Valekova, Ivona; Juhas, Stefan; Juhasova, Jana; Levinska, Bozena; Baxa, Monika; Motlik, Jan; Klima, Jiri; Howland, David; Wheeler, Vanessa C.; Bates, Gillian P.; Ellederova, Zdenka
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

TBK1在亨廷顿病模型中磷酸化突变亨廷顿蛋白并抑制其聚集和毒性

EMBO JOURNAL
IF8.3
2020-08-0527
OAAI
Hegde, Ramanath Narayana; Chiki, Anass; Petricca, Lara; Martufi, Paola; Arbez, Nicolas; Mouchiroud, Laurent; Auwerx, Johan; Landles, Christian; Bates, Gillian P.; Singh-Bains, Malvindar K.; Dragunow, Mike; Curtis, Maurice A.; Faull, Richard L. M.; Ross, Christopher A.; Caricasole, Andrea; Lashuel, Hilal A.
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model
BRAIN COMMUNICATIONS
IF4.5
2020-08-0331
OAAI
Landles, Christian; Milton, Rebecca E.; Ali, Nadira; Flomen, Rachel; Flower, Michael; Schindler, Franziska; Gomez-Paredes, Casandra; Bondulich, Marie K.; Osborne, Georgina F.; Goodwin, Daniel; Salsbury, Grace; Benn, Caroline L.; Sathasivam, Kirupa; Smith, Edward J.; Tabrizi, Sarah J.; Wanker, Erich E.; Bates, Gillian P.

研究方向

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G
Gillian P. Bates
H 指数:90论文数:370被引数:4.2万
G
Georgina F Osborne
H 指数:15论文数:38被引数:1,089
K
Kirupa Sathasivam
H 指数:26论文数:93被引数:7,980
S
Sarah J. Tabrizi
H 指数:100论文数:728被引数:3.7万
D
David Howland
H 指数:38论文数:128被引数:6,932
E
Edward J. Smith
H 指数:23论文数:97被引数:2,061
R
Rebecca Milton
H 指数:5论文数:18被引数:199
N
Nadira Ali
H 指数:13论文数:29被引数:1,118
R
Richard L. M. Faull
H 指数:104论文数:556被引数:4.0万
A
Andreas Neueder
H 指数:22论文数:79被引数:1,967