Gillian P. Bates - Publications, H-index & Citations

Gillian P. Bates

Charles University Prague

90H指数

368论文数

4.2W被引数

收录论文 168

发表时间

Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7 人类特有序列特征通过剪接因子SRSF7促进HTT外显子1的毒性错位处理

Nature Communications

IF15.7

2026-07-31

OAAI

Camilla Maffezzini; Raffaele Iennaco; Andrea Scolz; Simone Maestri; Christian Landles; Georgina F. Osborne; Marta M. Bronzini; Camilla Trovesi; Thomas Carzaniga; Luca Casiraghi; Jimena Quiros Ramirez; Thomas F. Vogt; Dan P. Felsenfeld; Tommaso Bellini; Chiara Zuccato; Gillian P. Bates; Elena Cattaneo

Molecular features of a Huntington's disease knock-in minipig 亨廷顿病基因敲入小型猪的分子特征

Disease Models & Mechanisms

IF3.3

2026-05-01

PREAI

Kolesnikova, Anastasiia; Sathasivam, Kirupa; Tusi, Solaleh Khoramian; Landles, Christian; Osborne, Georgina F.; Kovalenko, Marina; Gillis, Tammy; Kamenna, Eva; Sekac, David; Nguyen, Duong The; Valekova, Ivona; Juhas, Stefan; Juhasova, Jana; Levinska, Bozena; Baxa, Monika; Motlik, Jan; Klima, Jiri; Howland, David; Wheeler, Vanessa C.; Bates, Gillian P.; Ellederova, Zdenka

Lowering the HTT1a transcript as an effective therapy for Huntington’s disease in a knockin mouse model 降低HTT1a转录本作为亨廷顿病在敲入小鼠模型中的有效疗法

Science Translational Medicine

IF14.6

2026-03-18

PREAI

Aikaterini Smaragdi Papadopoulou; Julia Alterman; Christian Landles; Edward J. Smith; Faith Conroy; Jemima Phillips; Maria Canibano-Pico; Iulia M. Nita; Georgina F. Osborne; Arzo Iqbal; Sarah G. Aldous; Marie K. Bondulich; Casandra Gomez-Paredes; Kirupa Sathasivam; Daniel O’Reilly; Dimas Echeverria; Konstantin Bobkov; Jonathan R. Greene; Neil Aronin; Anastasia Khvorova; Gillian P. Bates

Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington’s disease mice 选择性靶向突变亨廷顿内含子1可改善反义寡核苷酸在亨廷顿病小鼠中的修复效果

Science Translational Medicine

IF14.6

2026-03-18

PREAI

Robert M. Bragg; Christian Landles; Edward J. Smith; Georgina F. Osborne; Ella W. Mathews; Jeffrey P. Cantle; Gillian P. Bates; Jeffrey B. Carroll

The HTT1a protein initiates HTT aggregation in a knock-in mouse model of Huntington’s disease

Brain

IF11.7

2026-02-02

OAAI

Aikaterini Smaragdi Papadopoulou; Christian Landles; Edward J Smith; Marie K Bondulich; Annett Boeddrich; Maria Canibano-Pico; Emily C E Danby; Franziska Hoschek; Arzo Iqbal; Samuel T Jones; Nancy Neuendorf; Iulia M Nita; Georgina F Osborne; Jemima Phillips; Maximilian Wagner; Erich E Wanker; Jonathan R Greene; Andreas Neueder; Gillian P Bates; null

Somatic CAG-repeat expansion drives neuronal loss in Huntington's disease 体细胞CAG-重复扩展导致亨廷顿病中的神经元丢失

NEURON

IF15

2025-02-01

PREAI

Bates, Gillian P.

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays 突变的亨廷顿蛋白随着CAG重复序列的扩增而减少: 对治疗和生物测定的影响

BRAIN COMMUNICATIONS

IF4.5

2024-11-15

OAAI

Landles, Christian; Osborne, Georgina F.; Phillips, Jemima; Canibano-Pico, Maria; Nita, Iulia M.; Ali, Nadira; Bobkov, Konstantin; Greene, Jonathan R.; Sathasivam, Kirupa; Bates, Gillian P.

m6A modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts 突变亨廷顿RNA的m6A修饰促进致病性亨廷顿转录本的生物合成

EMBO REPORTS

IF6.2

2024-10-11

PREAI

Pupak, Anika; Rodriguez-Navarro, Irene; Sathasivam, Kirupa; Singh, Ankita; Essmann, Amelie; del Toro, Daniel; Gines, Silvia; Mouro Pinto, Ricardo; Bates, Gillian P.; Vang orom, Ulf Andersson; Marti, Eulalia; Brito, Veronica

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models

BRAIN

IF11.7

2024-08-18

OAAI

Sogorb-Gonzalez, Marina; Landles, Christian; Caron, Nicholas S.; Stam, Anouk; Osborne, Georgina; Hayden, Michael R.; Howland, David; van Deventer, Sander; Bates, Gillian P.; Valles, Astrid; Evers, Melvin

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

MOLECULAR MEDICINE

IF6.4

2024-04-10

OAAI

Hoschek, Franziska; Natan, Julia; Wagner, Maximilian; Sathasivam, Kirupa; Abdelmoez, Alshaimaa; von Einem, Bjoern; Bates, Gillian P.; Landwehrmeyer, G. Bernhard; Neueder, Andreas

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

MOLECULAR MEDICINE

IF6.4

2024-03-08

OAAI

Hoschek, Franziska; Natan, Julia; Wagner, Maximilian; Sathasivam, Kirupa; Abdelmoez, Alshaimaa; von Einem, Bjoern; Bates, Gillian P.; Landwehrmeyer, G. Bernhard; Neueder, Andreas

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease 针对亨廷顿氏病体细胞不稳定性的治疗剂的CAG重复阈值

BRAIN

IF11.7

2024-02-22

OAAI

Aldous, Sarah G.; Smith, Edward J.; Landles, Christian; Osborne, Georgina F.; Canibano-Pico, Maria; Nita, Iulia M.; Phillips, Jemima; Zhang, Yongwei; Jin, Bo; Hirst, Marissa B.; Benn, Caroline L.; Bond, Brian C.; Edelmann, Winfried; Greene, Jonathan R.; Bates, Gillian P.

Translatable plasma and CSF biomarkers for use in mouse models of Huntington's disease

BRAIN COMMUNICATIONS

IF4.5

2024-02-07

OAAI

Bondulich, Marie K.; Phillips, Jemima; Canibano-Pico, Maria; Nita, Iulia M.; Byrne, Lauren M.; Wild, Edward J.; Bates, Gillian P.

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches

BRAIN COMMUNICATIONS

IF4.5

2023-01-20

OAAI

Smith, Edward J.; Sathasivam, Kirupa; Landles, Christian; Osborne, Georgina F.; Mason, Michael A.; Gomez-Paredes, Casandra; Taxy, Bridget A.; Milton, Rebecca E.; Ast, Anne; Schindler, Franziska; Zhang, Chuangchuang; Duan, Wenzhen; Wanker, Erich E.; Bates, Gillian P.

NOVEL BIOASSAYS TO DETECT SOLUBLE AND AGGREGATED ISOFORMS OF THE HUNTINGTIN PROTEIN ON THREE TECHNOLOGY PLATFORMS

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2022-09-12

PREAI

Landles, Christian; Osborne, Georgina F.; Milton, Rebecca E.; Jean, Alexandre; McLarnon, Stuart; Zhang, Chuangchuang; Duan, Wenzhen; Bates, Gillian P.

FAN1 CONTROLS CAG REPEAT EXPANSION IN HUNTINGTON'S DISEASE BY DUAL FUNCTIONS, MLH1 RETENTION AND NUCLEASE ACTIVITY

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2022-09-12

PREAI

Goold, Robert; Hamilton, Joseph; Menneteau, Thomas; Flower, Michael; Bunting, Emma; Aldous, Sarah; Porro, Antonio; Vicente, Jose; Allen, Nicholas; Wilkinson, Hilary; Bates, Gillian; Sartori, Alessandro; Thalassinos, Konstantinos; Balmus, Gabriel; Tabrizi, Sarah

THE TEMPORAL AND SPATIAL APPEARANCE OF HTT AGGREGATION IN THE BRAINS OF ZQ175 MICE

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2022-09-12

PREAI

Smith, Edward J.; Sathasivam, Kirupa; Landles, Christian; Osborne, Georgina F.; Gomez-Paredes, Casandra; Bates, Gillian P.

ANALYSIS OF BLOOD AND CSF BIOMARKERS IN MOUSE MODELS OF HUNTINGTON'S DISEASE

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2022-09-12

PREAI

Bondulich, Marie K.; Byrne, Lauren M.; Iqbal, Arzo; Nita, Iulia M.; Canibano-Pico, Maria; Phillips, Jemima M.; Wild, Edward; Bates, Gillian P.

ALTERNATIVE PROCESSING OF HUMAN HTT MRNA IN YAC128 MICE: IMPLICATIONS FOR HUNTINGTON'S DISEASE THERAPEUTICS

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2022-09-12

PREAI

Fienko, Sandra; Landles, Christian; Sathasivam, Kirupa; Gomez-Paredes, Casandra; McAteer, Sean; Milton, Rebecca; Osborne, Georgina F.; Jones, Samuel T.; Phillips, Jemima M.; Kordasiewicz, Holly B.; Bates, Gillian P.

ANALYSIS OF A HUNTINGTON'S DISEASE KNOCK-IN MOUSE MODEL DESIGNED TO PREVENT THE GENERATION OF THE EXON 1 HTT PROTEIN

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2022-09-12

PREAI

Papadopulou, Aikaterini-Smaragdi; Landles, Christian; Smith, Edward; Bondulich, Marie; Iqbal, Arzo; Osborne, Georgina F.; Howland, David; Neueder, Andreas; Bates, Gillian P.

研究方向