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Melina Mottin

Universidade Federal de Goiás
H指数:17
被引数:974

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Targeting HsDHODH: Shape and machine-learning guided discovery and structural validation of SARS-CoV-2 antivirals

靶向HsDHODH：基于形状和机器学习的SARS-CoV-2抗病毒药物的发现与结构验证

European Journal of Medicinal Chemistry
IF5.9
2026-07-010
PRE
Cruz, Luiza Vieira; Silva-Mendonca, Sabrina; da Purificacao, Aline Dias; Mottin, Melina; Arbelaez, Miguel; Freitas, Caroline S.; Fintelman-Rodrigues, Natalia; Mattos, Mayara; Froes, Thamires Quadros; Jurisch, Christopher D.; Seanego, Donald; Boyle, Grant A.; Campos, Fernanda de Franca Genuino Ramos; Souza, Thiago Moreno L.; Gessner, Richard K.; Chibale, Kelly; Nonato, Maria Cristina; Andrade, Carolina Horta
Front Cover: Structure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits (ChemMedChem 7/2026)

封面：基于结构与配体的新型类糜蛋白酶非肽类拟物先导物的发现 (ChemMedChem 7/2026)

ChemMedChem
IF3.4
2026-04-180
OAAI
Sabrina Silva-Mendonça; Donald Seanego; Christopher Jurisch; Melina Mottin; Flávia Nader Motta; Beatriz S. A. Rodrigues; Gilberto S. M. Junior; Alexandra Maria dos Santos Carvalho; Fábio Muniz de Oliveira; Sunniva Sigurdardóttir; Per Sunnerhagen; Izabela Marques Dourado Bastos; Richard Gessner; Kelly Chibale; Carolina Horta Andrade
Structure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits

基于结构和配体的新型类胰凝乳蛋白酶样蛋白酶非肽类拟物活性分子发现

ChemMedChem
IF3.4
2026-04-090
OA
Sabrina Silva-Mendonça; Donald Seanego; Christopher Jurisch; Melina Mottin; Flávia Nader Motta; Beatriz S. A. Rodrigues; Gilberto S. M. Junior; Alexandra Maria dos Santos Carvalho; Fábio Muniz de Oliveira; Sunniva Sigurdardóttir; Per Sunnerhagen; Izabela Marques Dourado Bastos; Richard Gessner; Kelly Chibale; Carolina Horta Andrade
Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study

新型乌米芬韦衍生物对SARS-CoV-2的增强抗病毒活性：国际协作研究启示

ACS Omega
IF4.3
2026-04-060
OA
Melina Mottin; Christopher D. Jurisch; Sabrina Silva-Mendonça; Donald Seanego; Paulo R. P. da Silva Ramos; Caroline S. Freitas; Mayara Mattos; Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Florence Guivel-Benhassine; Timothée Bruel; Liezl Krugmann; Ana C. Puhl; Fabio Urbina; Thomas R. Lane; Eric M. Merten; Kenneth H. Pearce; Alexander Lepioshkin; Artem Poromov; Natalia Monakhova; Olivier Schwartz; Kelly Chibale; Thiago M. L. Souza; Sean Ekins; Vadim Makarov; Richard K. Gessner; Carolina H. Andrade
INTEGRATIVE BEHAVIOR ANALYSIS, OXIDATIVE STRESS MARKERS DETERMINATION AND MOLECULAR DOCKING TO INVESTIGATE PROCONVULSANT ACTION OF BETALACTAMIC CARBAPENEMS

整合行为分析、氧化应激标志物测定及分子对接研究β-内酰胺类碳青霉烯类的致惊厥作用

NeuroToxicology
IF3.9
2025-08-080
PRE
Klistenes Alves de Lima; Alana Gomes de Souza; Adriano José Maia Chaves Filho; João Victor Souza Oliveira; Michele Albuquerque Jales de Carvalho; Melina Mottin; Camila Nayane de Carvalho Lima; Antonio Eufrásio Vieira-Neto; Iardja Stéfane Lopes Sales; Francisco Josimar Girão Júnior; Carolina Horta Andrade; Marta Maria de França Fonteles
Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation

SARS-CoV-2 PLpro的非共价抑制剂的发现: 整合虚拟筛选，合成和实验验证

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-12-020
OAAI
Sousa, Bruna K. P.; Mottin, Melina; Seanego, Donald; Jurisch, Christopher D.; Rodrigues, Beatriz S. A.; da Silva, Veronica L. S.; Andrade, Milene Aparecida; Morais Jr, Gilberto S.; Boerin, Diogo F.; Froes, Thamires Q.; Motta, Flavia Nader; Nonato, M. Cristina; Bastos, Izabela D. M.; Chibale, Kelly; Gessner, Richard K.; Andrade, Carolina Horta
Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2023-11-150
OA
Tomaz, Kaira C. P.; Tavella, Tatyana A.; Borba, Joyce V. B.; Salazar-Alvarez, Luis C.; Levandoski, Joao E.; Mottin, Melina; Sousa, Bruna K. P.; Moreira-Filho, Jose T.; Almeida, Vitor M.; Clementino, Leandro C.; Bourgard, Catarina; Massirer, Katlin B.; Counago, Rafael M.; Andrade, Carolina H.; Sunnerhagen, Per; Bilsland, Elizabeth; Cassiano, Gustavo C.; Costa, Fabio T. M.
Identification of novel Zika virus NS3 protease inhibitors with different inhibition modes by integrative experimental and computational approaches
BIOCHIMIE
IF3
2023-09-012
OAAI
Andrade, Milene Aparecida; Mottin, Melina; Sousa, Bruna K. de P.; Barbosa, Joao Alexandre Ribeiro Goncalves; dos Santos Azevedo, Clenia; Silva, Camila Lasse; de Andrade, Marina Goncalves; Motta, Flavia Nader; Maulay-Bailly, Christine; Amand, Severine; de Santana, Jaime Martins; Andrade, Carolina Horta; Grellier, Philippe; Bastos, Izabela M. D.
Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches
PHARMACEUTICALS
IF4.8
2022-11-3010
OAAI
Ramos, Paulo Ricardo Pimenta da Silva; Mottin, Melina; Lima, Caroline Sprengel; Assis, Leticia R.; de Oliveira, Ketllyn Zagato; Mesquita, Nathalya Cristina de Moraes Roso; Cassani, Natasha Marques; Santos, Igor Andrade; Borba, Joyce Villa Verde Bastos; Fiaia Costa, Vinicius Alexandre; Neves, Bruno Junior; Guido, Rafael Victorio Carvalho; Oliva, Glaucius; Jardim, Ana Carolina Gomes; Regasini, Luis Octavio; Andrade, Carolina Horta
Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika
JOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
2022-10-148
OA
Mottin, Melina; Sousa, Bruna Katiele de Paula; Mesquita, Nathalya Cristina de Moraes Roso; de Oliveira, Ketllyn Irene Zagato; Noske, Gabriela Dias; Sartori, Geraldo Rodrigues; Albuquerque, Aline de Oliveira; Urbina, Fabio; Puhl, Ana C.; Moreira-Filho, Jose Teofilo; Souza, Guilherme E.; Guido, Rafael V. C.; Muratov, Eugene; Neves, Bruno Junior; Silva, Joao Herminio Martins; Clark, Alex E.; Siqueira-Neto, Jair L.; Perryman, Alexander L.; Oliva, Glaucius; Ekins, Sean; Andrade, Carolina Horta
Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors
ACS OMEGA
IF4.3
2022-08-086
OA
Puhl, Ana C.; Mottin, Melina; Sacramento, Carolina Q. .; Tavella, Tatyana Almeida; Dias, Gabriel Goncalves; Fintelman-Rodrigues, Natalia; Temerozo, Jairo R. .; Dias, Suelen S. G.; Ramos, Paulo Ricardo Pimenta da Silva; Merten, Eric M.; Pearce, Kenneth H.; Costa, Fabio Trindade Maranha; Premkumar, Lakshmanane; Souza, Thiago Moreno L.; Andrade, Carolina Horta; Ekins, Sean
Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate
SCIENTIFIC REPORTS
IF3.9
2022-06-228
OAAI
Freire, Marjorie C. L. C.; Basso, Luis G. M.; Mendes, Luis F. S.; Mesquita, Nathalya C. M. R.; Mottin, Melina; Fernandes, Rafaela S.; Policastro, Lucca R.; Godoy, Andre S.; Santos, Igor A.; Ruiz, Uriel E. A.; Caruso, Icaro P.; Sousa, Bruna K. P.; Jardim, Ana C. G.; Almeida, Fabio C. L.; Gil, Laura H. V. G.; Andrade, Carolina H.; Oliva, Glaucius
Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
IF3.1
2022-06-0415
PRE
de Souza, Alana Gomes; Lopes, Iardja Stefane; Filho, Adriano Jose Maia Chaves; Cavalcante, Talita Matias Barbosa; Oliveira, Joao Victor Souza; de Carvalho, Michele Albuquerque Jales; de Lima, Klistenes Alves; Juca, Paloma Marinho; Mendonca, Sabrina Silva; Mottin, Melina; Andrade, Carolina Horta; de Sousa, Francisca Clea Florenco; Macedo, Danielle S.; de Franca Fonteles, Marta Maria
Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?
EUROPEAN NEUROPSYCHOPHARMACOLOGY
IF6.7
2021-01-0116
PREAI
Maia Chaves Filho, Adriano Jose; Cunha, Natassia Lopes; Rodrigues, Patricia de Araujo; de Souza, Alana Gomes; Soares, Michele Verde-Ramo; Juca, Paloma Marinho; de Queiroz, Tatiana; da Silva Clemente, Dino Cesar; Mottin, Melina; Andrade, Carolina Horta; Peixoto, Christina Alves; Macedo, Danielle S.
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax (vol 64, e02041-19, 2020)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2020-10-201
OAAI
Ferreira, Leticia Tiburcio; Rodrigues, Juliana; Cassiano, Gustavo Capatti; Tavella, Tatyana Almeida; Peralis Tomaz, Kaira Cristina; Baia-da-Silva, Djane Clarys; Souza, Macejane Ferreira; do Nascimento Lima, Marilia Nunes; Mottin, Melina; Almeida, Ludimila Dias; Calit, Juliana; Silva de Barros Puca, Maria Carolina; Melo, Gisely Cardoso; Bargieri, Daniel Youssef; Pinto Lopes, Stefanie Costa; Guimaraes Lacerda, Marcus Vinicius; Bilsland, Elizabeth; Sunnerhagen, Per; Neves, Bruno Junior; Andrade, Carolina Horta; Lemos Cravo, Pedro Vitor; Maranhao Costa, Fabio Trindade

研究方向

暂未获取到该数据
C
Carolina Horta Andrade
H 指数:39论文数:280被引数:6,264
S
Sean Ekins
H 指数:83论文数:711被引数:2.2万
B
Bruno J. Neves
H 指数:23论文数:142被引数:2,671
F
Fábio Trindade Maranhão Costa
H 指数:45论文数:206被引数:6,472
S
Sabrina Silva Mendonça
H 指数:6论文数:15被引数:108
P
Per Sunnerhagen
H 指数:34论文数:180被引数:4,625
D
Donald Seanego
H 指数:1论文数:5被引数:22
A
Adriano José Maia Chaves Filho
H 指数:22论文数:67被引数:1,523
D
Danielle S. Macêdo
H 指数:47论文数:311被引数:7,162
G
Glaucius Oliva
H 指数:48论文数:485被引数:9,293