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S

Sean Ekins

collaborations pharmaceuticals, inc.

83H指数
710论文数
2.3W被引数
收录论文 269
发表时间
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Efficacy; Structure–Activity Relationship; and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials疗效；构效关系；以及新一代基于吖啶/吖啶酮的抗疟药作用机制研究
errACS Infectious Diseases
IF3.8
err2026-05-25
err0
errOAAI
errSarah El Chamy Maluf; Giovana Rossi Mendes; Igor M. R. Moura; Guilherme Eduardo de Souza; Talita Alvarenga Valdes; Vinícius Bonatto; Gabriela Silva Oliveira; Anna Caroline Campos Aguiar; Marcos L. Gazarini; Ana C. Puhl; Natalia Monakhova; Alexander Lepioshkin; Vadim Makarov; Thomas R. Lane; Renuka Raman; Guilherme A. S. Campolina; Camila S. Barbosa; Amália dos Santos Ferreira; Carolina B. G. Teles; Dhelio B. Pereira; Roberto Rudge de Moraes Barros; Ernest Diez Benavente; Sean Ekins; Rafael Victorio Carvalho Guido
err分享
err收藏
Repurposing Clinical Candidates for Nipah and Hendra Viruses将临床候选药物用于尼帕病毒和亨德拉病毒
errACS Infectious Diseases
IF3.8
err2026-04-29
err0
PREAI
errThomas R. Lane; Olivier Escaffre; Lihong Zhang; Jennifer K. Smith; Terry L. Juelich; Alexander N. Freiberg; Sean Ekins
err分享
err收藏
MegaTrans® – Machine Learning Models for Drug Transporters Corresponding to the FDA GuidanceMegaTrans® – 与FDA指南对应的药物转运蛋白机器学习模型
errDrug Metabolism and Disposition
IF4
err2026-04-06
err0
PREAI
errPatricia A. Vignaux; Melanie Tojong; Alexander Kyu; Lucy J. Martinez; Guerrero, Joshua S. Harris; Thomas R. Lane; Stephen H. Wright; Nathan J. Cherrington; Sean Ekins
err分享
err收藏
Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study新型乌米芬韦衍生物对SARS-CoV-2的增强抗病毒活性：国际协作研究启示
errACS Omega
IF4.3
err2026-04-06
err0
errOAAI
errMelina Mottin; Christopher D. Jurisch; Sabrina Silva-Mendonça; Donald Seanego; Paulo R. P. da Silva Ramos; Caroline S. Freitas; Mayara Mattos; Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Florence Guivel-Benhassine; Timothée Bruel; Liezl Krugmann; Ana C. Puhl; Fabio Urbina; Thomas R. Lane; Eric M. Merten; Kenneth H. Pearce; Alexander Lepioshkin; Artem Poromov; Natalia Monakhova; Olivier Schwartz; Kelly Chibale; Thiago M. L. Souza; Sean Ekins; Vadim Makarov; Richard K. Gessner; Carolina H. Andrade
err分享
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Palmitoyl-protein thioesterase-1 in health and disease棕榈酰化蛋白硫酯酶-1在健康与疾病中
errTrends in Pharmacological Sciences
IF19.9
err2026-02-25
err0
PREAI
errMorgan Barnes; Renuka Raman; Sean Ekins
err分享
err收藏
Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates人类CYP2C9对有机磷农药和神经毒剂替代品的代谢
errJournal of Xenobiotics 2026, Vol. 16, Page 1
IF4.4
err2025-12-19
err0
errOAAI
errPratik Shriwas; Abigail M. Noonchester; Andre Revnew; Thomas R. Lane; Christopher M. Hadad; Sean Ekins; Craig A. McElroy
err分享
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Inhibition of equilibrative nucleoside transporters 1 and 2 by proteolysis-targeting chimeras (PROTACs)通过蛋白酶体靶向嵌合体(PROTACs)对平衡核苷转运蛋白1和2的抑制
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-12-01
err0
PREAI
errVignaux, Patricia A.; Guerrero, Lucy J. Martinez; Raman, Renuka; Lane, Thomas R.; Perez, Javier; Farrera, Dominique O.; Wright, Stephen H.; Cherrington, Nathan J.; Ekins, Sean
err分享
err收藏
Machine learning modeling of zebrafish toxicity endpoints after exposure to PROTACs斑马鱼暴露于PROTACs后的毒性终点机器学习建模
errTOXICOLOGICAL SCIENCES
IF4.1
err2025-12-01
err0
PREAI
errYogodzinski, Christopher; Harris, Joshua S.; Lane, Thomas R.; Barnes, Morgan; Vignaux, Patricia A.; Raman, Renuka; Truong, Lisa; Tanguy, Robyn L.; Kullman, Seth W.; Ekins, Sean
err分享
err收藏
Resilient pathways for drug discovery in challenging times在挑战时期用于药物发现的韧性路径
errTrends in Pharmacological Sciences
IF19.9
err2025-11-26
err0
PREAI
errSean Ekins; Barbara S. Slusher
err分享
err收藏
ToxPoint: The case for Equilibrative Nucleoside Transporters in current regulatory guidanceToxPoint：平衡核苷转运蛋白在现行监管指南中的案例
errTOXICOLOGICAL SCIENCES
IF4.1
err2025-10-01
err0
PREAI
errMartinez-Guerrero, Lucy; Tang, Xinyi; Ekins, Sean; Wright, Stephen H.; Cherrington, Nathan J.
err分享
err收藏
Applicability Domain Expansion Studies for Machine Learning Models Reveal New Inhibitors of CYP2B6机器学习模型的适用域扩展研究揭示了新的CYP2B6抑制剂
errDrug Metabolism and Disposition
IF4
err2025-09-09
err0
PREAI
errPatricia Vignaux; Joshua S. Harris; Fabio Urbina; Sean Ekins
err分享
err收藏
MegaEye: Applying multiple machine learning approaches to identify oral compounds with ocular bioactivityMegaEye：应用多种机器学习方法识别具有眼生物活性的口服化合物
errARTIFICIAL INTELLIGENCE IN THE LIFE SCIENCES
IF5.4
err2025-09-01
err0
errOAAI
errUrbina, Fabio; Greenwald, Scott H.; Vignaux, Patricia A.; Lane, Thomas R.; Harris, Joshua S.; Attar, Mayssa; Luhrs, Keith; Ekins, Sean
err分享
err收藏
DDI-CYP: Metabolism Ensemble Models for Drug-Drug Interaction PredictionsDDI-CYP：用于药物相互作用预测的代谢集成模型
errDrug Metabolism and Disposition
IF4
err2025-07-29
err0
PREAI
errJason T. Wong; Joshua S. Harris; Thomas R. Lane; Fabio Urbina; Sean Ekins
err分享
err收藏
Repurposing nicardipine leads to improved development in a young patient with Pitt–Hopkins syndrome利多卡因的再利用导致一名患有皮特-霍普金斯综合征的年轻患者发育改善
errFrontiers in Pharmacology
IF4.8
err2025-07-28
err0
errOAAI
errMarta Agnes Somorai; Sean Ekins; Claudia Rupprecht; Clara Lettl; Volker Mall
err分享
err收藏
Experimental and Computational Approaches for Evaluating Molecule Interactions with Equilibrative Nucleoside Transporters 1 and 2实验和计算方法在评价分子与易化核苷转运蛋白1和2相互作用中的应用
errpharmacology and experimental therapeutics
IF0
err2025-07-15
err0
PREAI
errLucy J. Martinez-Guerrero; Patricia A. Vignaux; Dominique O. Farrera; Joshua S. Harris; Renuka Raman; Thomas R. Lane; Stephen H. Wright; Sean Ekins; Nathan J. Cherrington
err分享
err收藏
Adverse Outcome Pathway and Machine Learning to Predict Drug Induced Seizure Liability不良结局路径与机器学习在预测药物诱导癫痫易感性中的应用
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2025-05-14
err0
PREAI
errLane, TR; Snyder, SH; Harris, JS; Urbina, F; Ekins, S
err分享
err收藏
Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPspFluor50的开发与表征：一种基于荧光底物的动力学测定系统，用于高通量抑制筛选及六种人CYP酶的时间依赖性抑制和抑制类型的表征
errMOLECULES
IF4.6
err2025-05-02
err0
errOAAI
errShriwas, Pratik; Revnew, Andre; Roo, Sarah; Bender, Alex; Miller, Kevin; Hadad, Christopher M.; Lane, Thomas R.; Ekins, Sean; McElroy, Craig A.
err分享
err收藏
Cryo-EM Structure of HIV-1 Reverse Transcriptase with N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine: A New HIV-1 Non-nucleoside InhibitorHIV-1逆转录酶与N-苯基-1-(苯磺酰基)-1H-1,2,4-三唑-3-胺的冷冻电镜结构：一种新的HIV-1非核苷类抑制剂
errACS INFECTIOUS DISEASES
IF3.8
err2025-04-30
err0
PREAI
errYoung, MA; Lane, TR; Raman, R; Nelson, JAE; Riabova, O; Kazakova, E; Monakhova, N; Tsedilin, A; Rees, SD; Quinnell, D; Makarov, V; Chang, GF; Ekins, S
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Mycobacterium tuberculosis Sulfate Ester Dioxygenase Rv3406 Is Able to Inactivate the RCB18350 Compound结核分枝杆菌硫酯双加氧酶Rv3406能够使RCB18350化合物失活
errACS INFECTIOUS DISEASES
IF3.8
err2025-03-20
err0
errOAAI
errRecchia, D; Stelitano, G; Egorova, A; Biffignandi, GB; Savková, K; Kafková, R; Huszár, S; Cerrato, AM; Slayden, RA; Cummings, JE; Whittel, N; Bauman, AA; Robertson, GT; Rank, L; Urbina, F; Lane, TR; Ekins, S; Riabova, O; Kazakova, E; Mikusová, K; Sassera, D; Degiacomi, G; Chiarelli, LR; Makarov, V; Pasca, MR
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Metabolic Characterization of Sarin, Cyclosarin, and Novichoks (A-230, A-232) in Human Liver Microsomes
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2025-01-15
err0
PREAI
errLane, Thomas R.; Koebel, David D.; Lucas, Eric A.; Cleary, Sean; Moyer, Robert; Ekins, Sean
err分享
err收藏

研究方向

暂无研究方向
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