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hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation hiPSC神经元重现了易感于神经退行性疾病相关聚集的亚型特异性细胞固有特性。 Weidling, I; Preiss, CN; Chancellor, SE; Srivastava, G; Gibilisco, L; Lin, G; Brennan, MS; Lee, J; Roth, LM; Morozova, O; Nam, KN; Patel, NR; Liu, Q; Thomas, JK; Reinhardt, P; Wilkens, R; Ehrnhoefer, DE; Striebinger, A; Barghorn, S; Xanthopoulos, C; Weil, MT; Biesinger, S; Cik, M; Romanul, N; Yanamandra, K; Welker, AM; Wu, J; Gasparini, L; Stöhr, J; Langlois, X; Manos, JD 分享 收藏
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau 沿阿尔茨海默病时空进展的脑髓细胞转录组景观揭示了对a β 和tau的不同顺序反应 Wachter, Astrid; Woodbury, Maya E.; Lombardo, Sylvia; Abdourahman, Aicha; Wuest, Carolin; Mcglame, Emily; Pastika, Timothy; Tamm, Joseph; Romanul, Nandini; Yanamandra, Kiran; Bennett, Rachel; Lin, Gen; Kwon, Taekyung; Liao, Fan; Klein, Corinna; Grinberg, Yelena; Jaisa-aad, Methasit; Li, Huan; Frosch, Matthew. P.; Kummer, Markus P.; Das, Sudeshna; Dellovade, Tammy; Karran, Eric H.; Langlois, Xavier; Ried, Janina S.; Serrano-Pozo, Alberto; Talanian, Robert V.; Biber, Knut; Hyman, Bradley T. 分享 收藏
Common mouse models of tauopathy reflect early but not late human disease Wenger, Kathrin; Viode, Arthur; Schlaffner, Christoph N.; van Zalm, Patrick; Cheng, Long; Dellovade, Tammy; Langlois, Xavier; Bannon, Anthony; Chang, Rui; Connors, Theresa R.; Oakley, Derek; Renard, Bernhard; Rappsilber, Juri; Hyman, Bradley; Steen, Hanno; Steen, Judith A. 分享 收藏
Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease Deleye, Steven; Waldron, Ann-Marie; Verhaeghe, Jeroen; Bottelbergs, Astrid; Wyffels, Leonie; Van Broeck, Bianca; Langlois, Xavier; Schmidt, Mark; Stroobants, Sigrid; Staelens, Steven 分享 收藏
Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging 用于Tau成像的新型PET示踪剂18F-JNJ64349311的临床前评估 Declercq, Lieven; Rombouts, Frederik; Koole, Michel; Fierens, Katleen; Marien, Jonas; Langlois, Xavier; Andres, Jose Ignacio; Schmidt, Mark; Macdonald, Gregor; Moechars, Diederik; Vanduffel, Wim; Tousseyn, Thomas; Vandenberghe, Rik; Laere, Koen Van; Verbruggen, Alfons; Bormans, Guy 分享 收藏
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease Rombouts, Frederik J. R.; Andres, Jose-Ignacio; Ariza, Manuela; Manuel Alonso, Jose; Austin, Nigel; Bottelbergs, Astrid; Chen, Lu; Chupakhin, Vladimir; Cleiren, Erna; Fierens, Katleen; Fontana, Alberto; Langlois, Xavier; Leenaerts, Joseph E.; Marien, Jonas; Lamenca, Carolina Martinez; Salter, Rhys; Schmidt, Mark E.; Te Riele, Paula; Wintmolders, Cindy; Trabanco, Andres A.; Zhang, Wei; Macdonald, Gregor; Moechars, Dieder 分享 收藏
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What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2 Leurquin-Sterk, Gil; Celen, Sofie; Van Laere, Koen; Koole, Michel; Bormans, Guy; Langlois, Xavier; Van Hecken, Anne; Riele, Paula te; Alcazar, Jesus; Verbruggen, Alfons; de Hoon, Jan; Andres, Jose-Ignacio; Schmidt, Mark E. 分享 收藏
Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates Ory, Dieter; Celen, Sofie; Gijsbers, Rik; Van Den Haute, Chris; Postnov, Andrey; Koole, Michel; Vandeputte, Caroline; Andres, Jose-Ignacio; Alcazar, Jesus; De Angelis, Med; Langlois, Xavier; Bhattacharya, Anindya; Schmidt, Mark; Letavic, Michael A.; Vanduffel, Wim; Van Laere, Koen; Verbruggen, Alfons; Debyser, Zeger; Bormans, Guy 分享 收藏
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Preclinical Comparison of the Amyloid-β Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis (vol 17, pg 688, 2015) Waldron, Ann-Marie; Verhaeghe, Jeroen; Wyffels, Leonie; Schmidt, Mark; Langlois, Xavier; Van Der Linden, Annemie; Stroobants, Sigrid; Staelens, Steven 分享 收藏
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia Conde-Ceide, Susana; Martinez-Viturro, Carlos M.; Alcazar, Jesus; Garcia-Barrantes, Pedro M.; Lavreysen, Hilde; Mackie, Claire; Vinson, Paige N.; Rook, Jerri M.; Bridges, Thomas M.; Daniels, J. Scott; Megens, Anton; Langlois, Xavier; Drinkenburg, Wilhelmus H.; Ahnaou, Abdellah; Niswender, Colleen M.; Jones, Carrie K.; Macdonald, Gregor J.; Steckler, Thomas; Conn, P. Jeffrey; Stauffer, Shaun R.; Manuel Bartolome-Nebreda, Jose; Lindsley, Craig W. 分享 收藏
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Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors Rombouts, Frederik J. R.; Tresadern, Gary; Buijnsters, Peter; Langlois, Xavier; Tovar, Fulgencio; Steinbrecher, Thomas B.; Vanhoof, Greet; Somers, Marijke; Andres, Jose-Ignacio; Trabanco, Andres A. 分享 收藏
Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia Manuel Bartolome-Nebreda, Jose; Alonso de Diego, Sergio A.; Artola, Marta; Delgado, Francisca; Delgado, Oscar; Luz Martin-Martin, Maria; Martinez-Viturro, Carlos M.; Angel Pena, Miguel; Min Tong, Han; Van Gool, Michiel; Manuel Alonso, Jose; Fontana, Alberto; Macdonald, Gregor J.; Megens, Anton; Langlois, Xavier; Somers, Marijke; Vanhoof, Greet; Conde-Ceide, Susana 分享 收藏
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JNJ-40255293, a Novel Adenosine A2A/A1 Antagonist with Efficacy in Preclinical Models of Parkinson's Disease Atack, John R.; Shook, Brian C.; Rassnick, Stefanie; Jackson, Paul F.; Rhodes, Kenneth; Drinkenburg, Wilhelmus H.; Ahnaou, Abdallah; te Riele, Paula; Langlois, Xavier; Hrupka, Brian; De Haes, Patrick; Hendrickx, Herman; Aerts, Nancy; Hens, Koen; Wellens, Annemie; Vermeire, Jef; Megens, Anton A. H. P. 分享 收藏
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