Philip J. Brooks

national institutes of health (nih) - usa

H指数:43

被引数:6,642

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2024-11-040

PRE

The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2024-02-065

PRE

Collaborative research efforts drive therapeutic advancements for free sialic acid storage disorder (FSASD)

MOLECULAR GENETICS AND METABOLISM

IF3.5

2024-02-010

PRE

Targeting shared molecular etiologies to accelerate drug development for rare diseases

针对共同的分子病因，加速罕见疾病的药物开发

EMBO MOLECULAR MEDICINE

IF8.3

2023-06-2710

OAAI

The past, present, and future of modeling Cockayne Syndrome - A commentary on Rat Model of Cockayne Syndrome Neurological Disease

Cockayne综合征模型的过去，现在和未来-Cockayne综合征神经疾病大鼠模型的评论

DNA REPAIR

IF2.7

2020-04-013

PREAI

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead (vol 47, pg 1206, 2019)

治疗罕见病: 治疗方式，进展和未来的挑战 (第47卷，1206页，2019)

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2020-01-080

OAAI

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

罕见病的治疗: 治疗方式、进展与挑战

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2019-12-13212

OAAI

Genome editing to 're-write' wrongs

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2018-06-228

PREAI

The cyclopurine deoxynucleosides: DNA repair, biological effects, mechanistic insights, and unanswered questions

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2017-06-0142

PREAI

Timeless insights into prevention of acetaldehyde genotoxicity?

CELL CYCLE

IF3.4

2017-01-314

OAAI

Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

氧化环嘌呤DNA损伤的RNA聚合酶II旁路机制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-01-2045

OAAI

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-09-2383

OAAI

Expanding rare disease drug trials based on shared molecular etiology

NATURE BIOTECHNOLOGY

IF41.7

2014-06-0917

OAAI

Blinded by the UV light: How the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease

DNA REPAIR

IF2.7

2013-08-0166

OAAI

Insight into mechanisms of 3′-5′ exonuclease activity and removal of bulky 8,5′-cyclopurine adducts by apurinic/apyrimidinic endonucleases

洞察3 ′-5 ′ 核酸外切酶活性和通过脱嘌呤/脱嘧啶核酸内切酶去除庞大的8,5 ′-环嘌呤加合物的机制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-07-2942

OAAI

Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA

细胞和组织DNA中Tet诱导的5-甲基胞嘧啶氧化产物的定量评估

NUCLEIC ACIDS RESEARCH

IF13.1

2013-05-08134

OAAI

Effects of 5′,8-Cyclodeoxyadenosine Triphosphates on DNA Synthesis

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-11-1617

PREAI

A quantitative assay for assessing the effects of DNA lesions on transcription

NATURE CHEMICAL BIOLOGY

IF13.7

2012-08-1987

Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion

NUCLEIC ACIDS RESEARCH

IF13.1

2012-05-1139

OAAI

Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice

着色性干皮病A组基因 (Xpa) 缺陷小鼠的精子发生受损和自发肿瘤发生升高

DNA REPAIR

IF2.7

2008-12-0122

OAAI

Philip J. Brooks

个人简介

教育背景

工作经历

荣誉奖项

研究方向