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P

Patrick A. Mayes

incyte research institute
H指数:21
被引数:3,869

个人简介

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荣誉奖项

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Discovery of a Selective and Potent Inhibitor of Cyclin-Dependent Kinase 12/13 Employing a Noncovalent Mechanism

使用非共价机制发现细胞周期蛋白依赖性激酶12/13的选择性和有效抑制剂

ACS Medicinal Chemistry Letters
IF4
2026-02-050
PRE
Robert A. Swyka; Evan D. Styduhar; Anlai Wang; Xin Li; Ke Zhang; Michael R. Witten; Peng Zhao; Michael Z. Liang; Onur Atasoylu; Peng He; Ryan Soderquist; Mike Hansbury; Lu Huo; Haiying Chen; Derek Zimmer; Wenliang Zhang; Kathy Wang; Alla Volgina; Leslie B. Epling; Erin Crowgey; Ekta Kumari; Angela Abdollahi; Guofeng Zhang; Mark Rupar; Michael Schaffer; Patrick A. Mayes; Sunkyu Kim; Oleg Vechorkin; Xiaozhao Wang
INCA33890, a novel PD-1xTGF.R2 bispecific antibody conditionally antagonizes TGFβ signaling in primary immune cells co- expressing PD-
CANCER RESEARCH
IF16.6
2023-04-041
PRE
Wang, Liang-Chuan S.; Klooster, Rinse; Kulkarni, Ashwini; de Vinuesa, Amaya Garcia; Soloviev, Maxim; Hendriks, Linda J. A.; Huo, Lu; Weber, Michael; Mondal, Arpita; Zhao, Yonghong; Harvey, Shane; He, Xin; Chang, Hong; Horsey, April; Volgina, Alla; Zhang, Yue; Pandey, Veethika; Yang, Yan-Ou; Rios-Doria, Jonathan; Eruslanov, Evgeniy; Powell, Daniel J.; Albelda, Steven M.; de Kruif, John; Nastri, Horacio; Geuijen, Cecile; Mayes, Patrick A.
A human CD137xPD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

人CD137xPD-L1双特异性抗体通过上下文依赖性T细胞共刺激和检查点阻断促进抗肿瘤免疫

NATURE COMMUNICATIONS
IF15.7
2021-07-2174
OAAI
Geuijen, Cecile; Tacken, Paul; Wang, Liang-Chuan; Klooster, Rinse; van Loo, Pieter Fokko; Zhou, Jing; Mondal, Arpita; Liu, Yao-bin; Kramer, Arjen; Condamine, Thomas; Volgina, Alla; Hendriks, Linda J. A.; van der Maaden, Hans; Rovers, Eric; Engels, Steef; Fransen, Floris; den Blanken-Smit, Renate; Zondag-van der Zande, Vanessa; Basmeleh, Abdul; Bartelink, Willem; Kulkarni, Ashwini; Marissen, Wilfred; Huang, Cheng-Yen; Hall, Leslie; Harvey, Shane; Kim, Soyeon; Martinez, Marina; O'Brien, Shaun; Moon, Edmund; Albelda, Steven; Kanellopoulou, Chrysi; Stewart, Shaun; Nastri, Horacio; Bakker, Alexander B. H.; Scherle, Peggy; Logtenberg, Ton; Hollis, Gregory; de Kruif, John; Huber, Reid; Mayes, Patrick A.; Throsby, Mark
Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune-mediated Antitumor Responses In Vivo
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-07-1271
OAAI
de Oca, Rocio Montes; Alavi, Alireza S.; Vitali, Nick; Bhattacharya, Sabyasachi; Blackwell, Christina; Patel, Krupa; Seestaller-Wehr, Laura; Kaczynski, Heather; Shi, Hong; Dobrzynski, Eric; Obert, Leslie; Tsvetkov, Lyuben; Cooper, David C.; Jackson, Heather; Bojczuk, Paul; Forveille, Sabrina; Kepp, Oliver; Sauvat, Allan; Kroemer, Guido; Creighton-Gutteridge, Mark; Yang, Jingsong; Hopson, Chris; Yanamandra, Niranjan; Shelton, Christopher; Mayes, Patrick; Opalinska, Joanna; Barnette, Mary; Srinivasan, Roopa; Smothers, James; Hoos, Axel
MCLA-145 IS A BISPECIFIC IGG1 ANTIBODY THAT INHIBITS PD-1/PD-L1 SIGNALING WHILE SIMULTANEOUSLY ACTIVATING CD137 SIGNALING ON T CELLS
JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2020-11-090
OAAI
Tacken, Paul; Wang, Liang-chuan; Klooster, Rinse; Van Loo, Pieter Fokko; Zhou, Jing; Mondal, Arpita; Liu, Yao-Bin; Kramer, Arjen; Condamine, Thomas; Volgina, Alla; Hendriks, Linda; van der Maaden, Hans; Rovers, Eric; Engels, Steef; Fransen, Floris; den Blanken-Smit, Renate; Zondag-van der Zande, Vanessa; Basmeleh, Abdul; Bartelink, Willem; Kulkarni, Ashwini; Marissen, Wilfred; Huang, Cheng-Yen; Hall, Leslie; Harvey, Shane; Kanellopoulou, Chrysi; Stewart, Shaun; Nastri, Horacio; Bakker, Lex; Logtenberg, Ton; Plyte, Simon; Mayes, Patrick; Throsby, Mark; Geuijen, Cecile
INDUCE-1: a phase I open-label study of GSK3359609, an ICOS agonist antibody, administered alone and in combination with pembrolizumab in patients with selected, advanced solid tumors
CANCER RESEARCH
IF16.6
2017-07-017
PRE
Angevin, Eric; Bauer, Todd M.; Ellis, Catherine E.; Gan, Hui; Hall, Rigel; Hansen, Aaron; Hoos, Axel; Jewell, Roxanne C.; Katz, Jessica; Martin-Liberal, Juan; Maio, Michele; Mayes, Patrick A.; Mazumdar, Jolly; Millward, Michael; Rischin, Danny; Schellens, Jan H.; Yadavilli, Sapna; Zhou, Helen
Novel anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity via enhanced effector function and direct tumor cell killing
CANCER RESEARCH
IF16.6
2014-10-010
PRE
Tai, Yu-Tzu; Acharya, Chirag; Zhong, Mike Y.; Cea, Michele; Cagnetta, Antonia; Mayes, Patrick A.; Craigen, Jenny; Gliddon, Louise; Smothers, James; Christie, Amanda L.; Kung, Andrew L.; Richardson, Paul; Munshi, Nikhil C.; Anderson, Kenneth C.

研究方向

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W
Wafik S. El‐Deiry
H 指数:120论文数:1,507被引数:8.7万
D
David T. Dicker
H 指数:47论文数:360被引数:6,614
J
John M. Maris
H 指数:115论文数:1,353被引数:5.3万
A
Axel Hoos
H 指数:67论文数:318被引数:4.2万
Gen Sheng Wu 封面图
Gen Sheng Wu
H 指数:53论文数:123被引数:1.5万
N
Nathan G. Dolloff
H 指数:23论文数:138被引数:1,894
J
Joshua E. Allen
H 指数:41论文数:564被引数:5,176
G
Gabriel Krigsfeld
H 指数:15论文数:40被引数:926
S
Sharon J. Diskin
H 指数:46论文数:335被引数:1.0万
S
Sapna Yadavilli
H 指数:10论文数:136被引数:840