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Gen Sheng Wu 封面图

Gen Sheng Wu

Barbara Ann Karmanos Cancer InstituteProfessor with Tenure
H指数:53
被引数:1.5万

个人简介

Research focuses on understanding cell signaling deregulation in human cancer and targeting pathways to improve therapies for breast, lung, and ovarian cancers. Current projects include developing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-based cancer therapy, elucidating the role of mitogen-activated protein kinase (MAPK) phosphatases, studying autophagy regulation, and investigating PD-L1 expression. Notable achievements include the discovery of the TRAIL death receptor DR5 and the co-discovery of the anticancer agent ONC201/dordaviprone (Modeyso™). ONC201 was approved by the FDA in August 2025 for the treatment of recurrent H3K27M-mutant diffuse midline glioma. Techniques used include cell and molecular biology, tumor mouse models, bioinformatics, RNA-seq, and immune assays.

教育背景

  • 1992.12

    Peking Union Medical College Ph.D.

工作经历

  • 2015.01 – 至今

    Department of Oncology and Department of Pathology, Wayne State University School of Medicine

    Professor with Tenure

  • 2011.01 – 2015.12

    Department of Oncology, Wayne State University School of Medicine

    Associate Professor with tenure

  • 2005.01 – 2015.12

    Karmanos Cancer Institute and Department of Pathology, Wayne State University School of Medicine

    Associate Professor with tenure

  • 2004.01 – 至今

    Cancer Biology Program, Wayne State University

    Graduate Faculty Member

  • 1999.01 – 2005.12

    Karmanos Cancer Institute and Department of Pathology, Wayne State University School of Medicine

    Assistant Professor

  • 1999.01 – 至今

    Karmanos Cancer Institute

    Member

  • 1995.01 – 1999.12

    Howard Hughes Medical Institute at University of Pennsylvania

    Post-Doc

  • 1993.01 – 1995.12

    University of Pittsburgh School of Medicine

    Post-Doc

荣誉奖项

  1. Penn State Hershey Innovators Award｜US
  2. Karmanos Cancer Center Director's Award（2007）｜Karmanos Cancer Institute

研究方向

cell signaling deregulationcancer therapy targetingautophagy regulationPD-L1 expressionTRAIL-based therapyMAPK phosphatases
W
Wafik S. El‐Deiry
H 指数:120论文数:1,507被引数:8.7万
J
Junying Zhou
H 指数:36论文数:164被引数:5,742
J
Jun-Ying Zhou
H 指数:11论文数:20被引数:954
J
Jing Xu
H 指数:28论文数:95被引数:2,757
J
Julio Pimentel
H 指数:7论文数:19被引数:199
D
David T. Dicker
H 指数:47论文数:360被引数:6,595
G
Gabriel Krigsfeld
H 指数:15论文数:40被引数:923
P
Patrick A. Mayes
H 指数:21论文数:187被引数:3,858
M
Malathy P.V. Shekhar
H 指数:29论文数:90被引数:2,820
W
Wanchun Wang
H 指数:34论文数:243被引数:3,685