Jonathan D. Powell - Publications, H-index & Citations

Jonathan D. Powell

johns hopkins

72H指数

320论文数

2.5W被引数

收录论文 122

发表时间

Retraction Note: Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer 撤稿说明：经过重新设计的BCG过量表达环二腺苷酸，增强了训练性免疫，并显示出对膀胱癌的改进效果。

Nature Communications

IF15.7

2026-03-23

OAAI

Alok Kumar Singh; Monali Praharaj; Kara A. Lombardo; Takahiro Yoshida; Andres Matoso; Alex S. Baras; Liang Zhao; Geetha Srikrishna; Joy Huang; Pankaj Prasad; Jonathan D. Powell; Max Kates; David McConkey; Drew M. Pardoll; William R. Bishai; Trinity J. Bivalacqua

Systematic metabolite screening identifies functional regulators of the adenosine A2A receptor 系统性代谢物筛选鉴定出腺苷A2A受体的功能调节剂

Communications Chemistry

IF6.2

2025-12-09

OAAI

Prashant Rao; Manoj Rathinaswamy; Michelle Chan; Andrea Guzmán Paredes; Chirag Patel; Bernd J. Wranik; Jonathan Powell; Dan Eaton; Jared Rutter; Kevin G. Hicks; Amirhossein Mafi; Qi Hao

More TOR: The expanding role of mTOR in regulating immune responses 更多TOR：mTOR在调节免疫反应中不断扩展的作用

Immunity

IF26.3

2025-06-30

PREAI

Chirag H. Patel; Jonathan D. Powell

SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation

JOURNAL OF IMMUNOLOGY

IF3.4

2023-11-10

PREAI

Helms, Rachel S.; Marin-Gonzalez, Alberto; Patel, Chirag H.; Sun, Im-Hong; Wen, Jiayu; Leone, Robert D.; Duvall, Bridget; Gao, Run-Duo; Ha, Taekjip; Tsukamoto, Takashi; Slusher, Barbara S.; Pomerantz, Joel L.; Powell, Jonathan D.

TSC2 S1365A mutation potently regulates CD8+T cell function and differentiation and improves adoptive cellular cancer therapy

JCI INSIGHT

IF6.1

2023-11-08

OAAI

Patel, Chirag H.; Yi, Dong; Koleini, Navid; Wang, Xiaoxu; Dunkerly-Eyring, Brittany L.; Wen, Jiayu; Ranek, Mark J.; Bartle, Laura M.; Henderson, Daniel B.; Sagert, Jason; Kass, David A.; Powell, Jonathan D.

Sirolimus-eluting airway stent reduces profibrotic Th17 cells and inhibits laryngotracheal stenosis

JCI INSIGHT

IF6.1

2023-06-08

OAAI

Motz, Kevin M.; Lina, Ioan A.; Samad, Idris; Murphy, Michael K.; Duvvuri, Madhavi; Davis, Ruth J.; Gelbard, Alexander; Chung, Liam; Chan-Li, Yee; Collins, Samuel; Powell, Jonathan D.; Elisseeff, Jennifer H.; Horton, Maureen R.; Hillel, Alexander T.

Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers

CANCER RESEARCH

IF16.6

2023-06-02

PREAI

Praharaj, Monali; Shen, Fan; Lee, Alex J.; Zhao, Liang; Nirschl, Thomas R.; Wang, Xiaoxu; Theodros, Debebe; Singh, Alok K.; Williams, Raekwon A.; Sena, Laura A.; Thompson, Elizabeth A.; Tam, Ada; Yegnasubramanian, Srinivasan; Pearce, Edward J.; Leone, Robert D.; Alt, Jesse; Rais, Rana; Slusher, Barbara S.; Pardoll, Drew M.; Powell, Jonathan D.; Zarif, Jelani C.

First-in-human phase 1 studies of PTPN2/1 inhibitors ABBV-CLS-484 and ABBV-CLS-579 in locally advanced or metastatic tumors

CANCER RESEARCH

IF16.6

2023-04-14

PREAI

LoRusso, Patricia M.; Aller, Emiliano Calvo; Yamamoto, Noboru; Lin, Chia-Chi; Beck, Thaddeus; Sommerhalder, David; Oh, Do-Youn; Powderly, John D.; Golan, Talia; Abraham, Linu Sara; Hayflick, Joel S.; Uziel, Tamar; Brunsdon, Priya; Munasinghe, Wijith; Paddock, Marcia; Hartman, Cathleen Brdlik; Powell, Jonathan; Medeiros, Bruno; Neagu, Martha R.; Carneiro, Benedito A.

Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages (TAMs) to drive tumor immunity in urologic cancers

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Praharaj, Monali; Shen, Fan; Lee, Alex J.; Zhao, Liang; Nirschl, Thomas; Wang, Xiaoxu; Theodros, Debebe; Singh, Alok K.; Williams, Raekwon A.; Sena, Laura A.; Thompson, Elizabeth A.; Tam, Ada; Yegnasubramanian, Srinivasan; Pearce, Edward J.; Leone, Robert D.; Alt, Jesse; Rais, Rana; Slusher, Barbara S.; Pardoll, Andrew M.; Powell, Jonathan D.; Zarif, Jelani C.

GOT1 regulates CD8+effector and memory T cell generation

CELL REPORTS

IF6.9

2023-01-01

OAAI

Xu, Wei; Patel, Chirag H.; Zhao, Liang; Sun, Im-Hong; Oh, Min-Hee; Sun, Im-Meng; Helms, Rachel S.; Wen, Jiayu; Powell, Jonathan D.

Cutting Edge: mTORC2 Regulates CD8+Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase

JOURNAL OF IMMUNOLOGY

IF3.4

2022-12-15

OAAI

Patel, Chirag H.; Heikamp, Emily B.; Xu, Wei; Sun, Im-Hong; Oh, Min-Hee; Sun, Im-Meng; Wen, Jiayu; Tam, Ada J.; Blosser, Richard L.; Powell, Jonathan D.

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug 肿瘤靶向代谢抑制剂前药DRP-104的发现

SCIENCE ADVANCES

IF12.5

2022-11-16

OAAI

Rais, Rana; Lemberg, Kathryn M.; Tenora, Lukas; Arwood, Matthew L.; Pal, Arindom; Alt, Jesse; Wu, Ying; Lam, Jenny; Aguilar, Joanna Marie H.; Zhao, Liang; Peters, Diane E.; Tallon, Carolyn; Pandey, Rajeev; Thomas, Ajit G.; Dash, Ranjeet P.; Seiwert, Tanguy; Majer, Pavel; Leone, Robert D.; Powell, Jonathan D.; Slusher, Barbara S.

Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge

SCIENCE IMMUNOLOGY

IF16.3

2022-05-27

OAAI

Claiborne, Michael D.; Sengupta, Srona; Zhao, Liang; Arwood, Matthew L.; Sun, Im-Meng; Wen, Jiayu; Thompson, Elizabeth A.; Mitchell-Flack, Marisa; Laiho, Marikki; Powell, Jonathan D.

Enhanced T cell effector function upon differentiation of CD8+ and CD4+ T cells in the presence of BioE-1197 through potential off target ARK family inhibition

JOURNAL OF IMMUNOLOGY

IF3.4

2022-05-01

PREAI

Helms, Rachel Shannon; Patel, Chirag H.; Leone, Robert D.; Duvall, Bridget; Gao, Run-Duo; Tsukamoto, Takashi; Slusher, Barbara S.; Pomerantz, Joel L.; Powell, Jonathan D.

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

COMMUNICATIONS BIOLOGY

IF5.1

2022-03-18

OAAI

Ordonez, Alvaro A.; Bullen, C. Korin; Villabona-Rueda, Andres F.; Thompson, Elizabeth A.; Turner, Mitchell L.; Merino, Vanessa F.; Yan, Yu; Kim, John; Davis, Stephanie L.; Komm, Oliver; Powell, Jonathan D.; D'Alessio, Franco R.; Yolken, Robert H.; Jain, Sanjay K.; Jones-Brando, Lorraine

Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer

NATURE COMMUNICATIONS

IF15.7

2022-02-15

OAAI

Singh, Alok Kumar; Praharaj, Monali; Lombardo, Kara A.; Yoshida, Takahiro; Matoso, Andres; Baras, Alex S.; Zhao, Liang; Srikrishna, Geetha; Huang, Joy; Prasad, Pankaj; Powell, Jonathan D.; Kates, Max; McConkey, David; Pardoll, Drew M.; Bishai, William R.; Bivalacqua, Trinity J.

mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism

JOURNAL OF IMMUNOLOGY

IF3.4

2021-08-01

OAAI

Collins, Samuel L.; Oh, Min-Hee; Sun, Im-Hong; Chan-Li, Yee; Zhao, Liang; Powell, Jonathan D.; Horton, Maureen R.

Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2021-05-17

OAAI

Dykema, Arbor G.; Zhang, Boyang; Woldemeskel, Bezawit A.; Garliss, Caroline C.; Cheung, Laurene S.; Choudhury, Dilshad; Zhang, Jiajia; Aparicio, Luis; Bom, Sadhana; Rashid, Rufiaat; Caushi, Justina X.; Hsiue, Emily Han-Chung; Cascino, Katherine; Thompson, Elizabeth A.; Kwaa, Abena K.; Singh, Dipika; Thapa, Sampriti; Ordonez, Alvaro A.; Pekosz, Andrew; D'Alessio, Franco R.; Powell, Jonathan D.; Yegnasubramanian, Srinivasan; Zhou, Shibin; Pardoll, Drew M.; Ji, Hongkai; Cox, Andrea L.; Blankson, Joel N.; Smith, Kellie N.

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance 抗原驱动的EGR2表达是耗尽CD8 T细胞稳定性和维持所必需的

NATURE COMMUNICATIONS

IF15.7

2021-05-13

OAAI

Wagle, Mayura, V; Vervoort, Stephin J.; Kelly, Madison J.; Van der Byl, Willem; Peters, Timothy J.; Martin, Ben P.; Martelotto, Luciano G.; Nuessing, Simone; Ramsbottom, Kelly M.; Torpy, James R.; Knight, Deborah; Reading, Sinead; Thia, Kevin; Miosge, Lisa A.; Howard, Debbie R.; Gloury, Renee; Gabriel, Sarah S.; Utzschneider, Daniel T.; Oliaro, Jane; Powell, Jonathan D.; Luciani, Fabio; Trapani, Joseph A.; Johnstone, Ricky W.; Kallies, Axel; Goodnow, Christopher C.; Parish, Ian A.

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

CELL REPORTS

IF6.9

2021-03-01

OAAI

Thompson, Elizabeth A.; Cascino, Katherine; Ordonez, Alvaro A.; Zhou, Weiqiang; Vaghasia, Ajay; Hamacher-Brady, Anne; Brady, Nathan R.; Sun, Im-Hong; Wang, Rulin; Rosenberg, Avi Z.; Delannoy, Michael; Rothman, Richard; Fenstermacher, Katherine; Sauer, Lauren; Shaw-Saliba, Kathyrn; Bloch, Evan M.; Redd, Andrew D.; Tobian, Aaron A. R.; Horton, Maureen; Smith, Kellie; Pekosz, Andrew; D'Alessio, Franco R.; Yegnasubramanian, Srinivasan; Ji, Hongkai; Cox, Andrea L.; Powell, Jonathan D.

研究方向