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A

Andrew J. Souers

AbbVie
H指数:42
被引数:9,936

个人简介

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教育背景

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工作经历

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荣誉奖项

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Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

内在凋亡机制的综合分子和功能表征可确定神经胶质瘤的治疗脆弱性

NATURE COMMUNICATIONS
IF15.7
2024-11-210
OAAI
Fernandez, Elizabeth G.; Mai, Wilson X.; Song, Kai; Bayley, Nicholas A.; Kim, Jiyoon; Zhu, Henan; Pioso, Marissa; Young, Pauline; Andrasz, Cassidy L.; Cadet, Dimitri; Liau, Linda M.; Li, Gang; Yong, William H.; Rodriguez, Fausto J.; Dixon, Scott J.; Souers, Andrew J.; Li, Jingyi Jessica; Graeber, Thomas G.; Cloughesy, Timothy F.; Nathanson, David A.
BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors
SCIENCE ADVANCES
IF12.5
2024-10-041
OAAI
Judd, Andrew S.; Bawa, Bhupinder; Buck, Wayne R.; Tao, Zhi-Fu; Li, Yingchun; Mitten, Michael J.; Bruncko, Milan; Catron, Nathaniel; Doherty, George; Durbin, Kenneth R.; Enright, Brian; Frey, Robin; Haasch, Deanna; Haman, Sandra; Haight, Anthony R.; Henriques, Tracy A.; Holms, James; Izeradjene, Kamel; Judge, Russell A.; Jenkins, Gary J.; Kunzer, Aaron; Leverson, Joel D.; Martin, Ruth L.; Mitra, Diya; Mittelstadt, Scott; Nelson, Lorne; Nimmer, Paul; Palma, Joann; Peterson, Richard; Phillips, Darren C.; Ralston, Sherry L.; Rosenberg, Saul H.; Shen, Xiaoqiang; Song, Xiaohong; Vaidya, Kedar R.; Wang, Xilu; Wang, Jin; Xiao, Yu; Zhang, Haichao; Zhang, Xinxin; Blomme, Eric A.; Boghaert, Erwin R.; Kalvass, John C.; Phillips, Andrew; Souers, Andrew J.
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
COMMUNICATIONS MEDICINE
IF6.3
2023-10-2520
OAAI
Yuda, Junichiro; Will, Christine; Phillips, Darren C.; Abraham, Linu; Alvey, Cory; Avigdor, Abraham; Buck, Wayne; Besenhofer, Lauren; Boghaert, Erwin; Cheng, Dong; Cojocari, Dan; Doyle, Kelly; Hansen, T. Matthew; Huang, Kevin; Johnson, Eric F.; Judd, Andrew S.; Judge, Russell A.; Kalvass, John C.; Kunzer, Aaron; Lam, Lloyd T.; Li, Rachel; Martin, Ruth L.; Mastracchio, Anthony; Mitten, Mike; Petrich, Adam; Wang, Jin; Ward, James E.; Zhang, Haichao; Wang, Xilu; Wolff, Johannes E.; Bell-McGuinn, Katherine M.; Souers, Andrew J.
Identification of recurrent genomic alterations in the apoptotic machinery in chronic lymphocytic leukemia patients treated with venetoclax monotherapy
AMERICAN JOURNAL OF HEMATOLOGY
IF9.9
2021-11-249
OA
Popovic, Relja; Dunbar, Fengjiao; Lu, Charles; Robinson, Kenneth; Quarless, Danjuma; Warder, Scott E.; Mukherjee, Nabanita; Pesko, John; Souers, Andrew J.; Waring, Jeffrey F.; Davids, Matthew S.; Tausch, Eugen; Stilgenbauer, Stephan; Ross, Jeremy A.; Leverson, Joel D.; Kim, Su Young; Chyla, Brenda J.
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2021-06-223
OAAI
Tong, Yunsong; Florjancic, Alan S.; Clark, Rick F.; Lai, Chunqiu; Mastracchio, Anthony; Zhu, Gui-dong; Smith, Morey L.; Kovar, Peter J.; Shaw, Bailin; Albert, Daniel H.; Qiu, Wei; Longenecker, Kenton L.; Liu, Xiaoqin; Olson, Amanda M.; Osterling, Donald J.; Tahir, Stephen K.; Phillips, Darren C.; Leverson, Joel D.; Souers, Andrew J.; Penning, Thomas D.
Expanding the Repertoire for Large Small Molecules: Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-03-3014
OA
Salem, Ahmed Hamed; Tao, Zhi-Fu; Bueno, Orlando F.; Chen, Jie; Chen, Shuang; Edalji, Rohinton; Elmore, Steven W.; Fournier, Keith M.; Harper, Kaid C.; Hong, Richard; Jenkins, Gary J.; Ji, Jianguo; Judge, Russell A.; Kalvass, John C.; Klix, Russell C.; Ku, Yi-Yin; Leverson, Joel D.; Marks, Richard A.; Marsh, Kennan C.; Menon, Rajeev M.; Park, Chang H.; Phillips, Darren C.; Pu, Yu-Ming; Rosenberg, Saul H.; Sanzgiri, Yeshwant D.; Sheikh, Ahmad Y.; Shi, Yi; Stolarik, Deanne; Suleiman, Ahmed A.; Wang, Xilu; Zhang, Geoff G. Z.; Catron, Nathaniel D.; Souers, Andrew J.

研究方向

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D
Darren C. Phillips
H 指数:26论文数:113被引数:6,458
L
Leverson, Joel D.
H 指数:0论文数:28被引数:9
A
Andrew S. Judd
H 指数:19论文数:58被引数:1,290
E
Erwin R. Boghaert
H 指数:36论文数:189被引数:8,046
W
Wayne J. Fairbrother
H 指数:61论文数:263被引数:1.8万
S
Stephen K. Tahir
H 指数:33论文数:122被引数:1.2万
S
Steven W. Elmore
H 指数:38论文数:199被引数:1.5万
P
Philip R. Kym
H 指数:42论文数:134被引数:5,740
M
Morey L. Smith
H 指数:25论文数:77被引数:6,587
Z
Zhi‐Fu Tao
H 指数:24论文数:77被引数:3,254