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S

Stephen Neidle

pharmacy

H指数:101

被引数:3.9万

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DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC

G-四链体配体QN-302的DNA损伤特性被DNA修复抑制剂奥拉帕利增强，而由分子解旋酶PhpC缓解

IF9.4

2026-04-110

OAAI

Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells

细胞适应性影响萘二亚胺G-四链体配体在ALT阳性骨肉瘤细胞中的生物活性

Cell Death & Disease

IF9.6

2025-08-010

OAAI

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers-Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence

ACS CHEMICAL BIOLOGY

IF3.8

2025-02-070

PRE

Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene

N-甲基中卟啉IX与SLC2A1基因启动子的杂合左手/右手G-四链体基序的相互作用

NUCLEIC ACIDS RESEARCH

IF13.1

2024-12-190

OAAI

A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs

IF4.6

2024-08-0110

OAAI

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation

NUCLEIC ACIDS RESEARCH

IF13.1

2024-07-110

OAAI

Early clinical experience with a novel first-in-class G-quadruplex experimental anti-cancer drug

CANCER RESEARCH

IF16.6

2024-04-051

PRE

The pan-quadruplex drug QN-302 selectively down-regulates key pathway targets in pancreatic cancer cells that are up- regulated in human pancreatic cancer

CANCER RESEARCH

IF16.6

2024-03-220

PRE

The pan-quadruplex drug QN-302 targets up-regulated genes in pancreatic cancer and in other cancer types and correlate with poor patient prognosis

CANCER RESEARCH

IF16.6

2024-03-220

PRE

Characterization of the biological effects of a quadruplex-interacting molecule in dedifferentiated liposarcoma cells

CANCER RESEARCH

IF16.6

2024-03-220

PRE

Structure-activity relationships for the pan-quadruplex experimental drug QN-302 and two analogs probed with comparative transcriptome profiling and molecular modeling

CANCER RESEARCH

IF16.6

2024-03-220

PRE

Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling

SCIENTIFIC REPORTS

IF3.9

2024-02-1119

OAAI

On Water Arrangements in Right- and Left-Handed DNA Structures

IF4.6

2024-01-194

OAAI

The pan-quadruplex experimental drug QN-302 in pancreatic ductal adenocarcinoma (PDAC): Potential biomarkers for clinical studies

CANCER RESEARCH

IF16.6

2024-01-160

PRE

Target genes in pancreatic cancer cells of the pan-quadruplex clinical candidate compound QN-302 revealed by comparative transcriptome profiling

CANCER RESEARCH

IF16.6

2024-01-160

PRE

On the origins of the conflict between Rosalind Franklin and Maurice Wilkins

NATURE REVIEWS CHEMISTRY

IF51.7

2023-10-120

PRE

A comparison of the activity of the quadruplex-targeting experimental drugs QN-302 and CX-5461 (pidnarulex) in wild-type and gemcitabine-resistant pancreatic cancer cell lines

CANCER RESEARCH

IF16.6

2023-04-041

PRE

Structure-based design rules for potent quadruplex-binding compounds based on the naphthalene diimide core

CANCER RESEARCH

IF16.6

2023-04-040

PRE

The potent quadruplex-binding compound QN302 shows anti-tumor activity as a monotherapy in an orthotopic in vivo model of pancreatic cancer

CANCER RESEARCH

IF16.6

2023-04-040

PRE

The potent quadruplex-binding compound QN-302 down-regulates the S100P gene in in vitro and in vivo models of pancreatic cancer: a potential therapeutic target and biomarker for PDAC

CANCER RESEARCH

IF16.6

2023-04-040

PRE