logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
J

John R. Engen

Northeastern University

64H指数
302论文数
1.7W被引数
收录论文 129
发表时间
logo
Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveal that the Oncogenic Y220C Variant is a Loss-of-Function Mutation for Zn2+-Binding at Physiological Temperature热力学分析揭示野生型与Y220C TP53 DBDs，表明在生理温度下致癌性Y220C变异体是锌离子结合功能的失活突变
errBiochemistry
IF3
err2026-09-15
err0
PREAI
errJacob I. Stuckey; Valerie Vivat; Bradley M. Dickson; Jeremy W. Setser; Yong Li; Claudia M. Cremers; Jonathan E. Wilson; Daniele Peterle; John R. Engen; Thomas E. Wales; Rainer Wilcken; Erin B. Rohan; Gregg Chenail; James E. Audia; Robert J. Sims III
err分享
err收藏
Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications镁作为KRAS的构象门控开关：结构动力学与治疗意义
errProtein Science
IF5.2
err2026-06-18
err0
errOAAI
errBindu Y. Srinivasu; Tanvi S. Damerla; Alexander Stec; Zhiwei Zhou; John R. Engen; Kenneth D. Westover; Thomas E. Wales
err分享
err收藏
Correction: Dynamic conformational equilibria in the active states of KRAS and NRAS更正：KRAS和NRAS活性状态中的动态构象平衡
errrsc chem. biol.
IF0
err2026-05-06
err0
errOAAI
errEnrico Rennella; Chrystèle Henry; Callum J. Dickson; Florian Georgescauld; Thomas E. Wales; Dirk Erdmann; Simona Cotesta; Michel Maira; Richard Sedrani; Saskia M. Brachmann; Nils Ostermann; John R. Engen; Lewis E. Kay; Kim S. Beyer; Rainer Wilcken; Wolfgang Jahnke
err分享
err收藏
Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level利用氢/氘交换质谱分析核糖体-新生链复合物，以在肽水平上研究蛋白质生物合成
errNature Protocols
IF16
err2026-01-12
err0
PREAI
errAlžběta Roeselová; Aleksandra Pajak; Thomas E. Wales; Grant A. Pellowe; Svend Kjær; John R. Engen; David Balchin
err分享
err收藏
Inhibition of oligomeric BAX by an anti-apoptotic dimer抗凋亡二聚体对寡聚BAX的抑制
errCell
IF42.5
err2025-11-21
err0
PREAI
errCatherine E. Newman; Micah A. Gygi; Haleh Alimohamadi; Thomas M. DeAngelo; Christina M. Camara; Julian Mintseris; Ezra Yu; Edward P. Harvey; Zachary J. Hauseman; Lixin Fan; Yun-Xing Wang; Elizabeth W.-C. Luo; Marina Godes; Jacob Gehtman; Ann M. Cathcart; Steven P. Gygi; John R. Engen; Gregory H. Bird; Gerard C.L. Wong; Thomas E. Wales
err分享
err收藏
Rigorous Analysis of Multimodal HDX-MS Spectra多模态hdx-ms光谱的严格分析
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2025-01-21
err0
PREAI
errTuttle, Lisa M.; James, Ellie I.; Georgescauld, Florian; Wales, Thomas E.; Weis, David D.; Engen, John R.; Nath, Abhinav; Klevit, Rachel E.; Guttman, Miklos
err分享
err收藏
Dynamic conformational equilibria in the active states of KRAS and NRASKRAS和NRAS活性状态下的动态构象平衡
errRSC CHEMICAL BIOLOGY
IF3.1
err2025-01-01
err0
errOAAI
errRennella, Enrico; Henry, Chrystele; Dickson, Callum J.; Georgescauld, Florian; Wales, Thomas E.; Erdmann, Dirk; Cotesta, Simona; Maira, Michel; Sedrani, Richard; Brachmann, Saskia M.; Ostermann, Nils; Engen, John R.; Kay, Lewis E.; Beyer, Kim S.; Wilcken, Rainer; Jahnke, Wolfgang
err分享
err收藏
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, HckSH3-binding变构调节剂稳定AML相关Src家族激酶Hck的整体构象
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-01-01
err0
errOAAI
errSelzer, Ari M.; Gerlach, Gabriella; Gonzalez-Areizaga, Giancarlo; Wales, Thomas E.; Cui, Stephanie Y.; Iyer, Prema; Engen, John R.; Camacho, Carlos; Ishima, Rieko; Smithgall, Thomas E.
err分享
err收藏
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia临床批准的BTK抑制剂对慢性淋巴细胞白血病全长BTK构象的影响及BTK耐药突变的发展分析
errELIFE
IF0
err2024-12-27
err1
errOAAI
errJoseph, Raji E.; Wales, Thomas E.; Jayne, Sandrine; Britton, Robert G.; Fulton, D. Bruce; Engen, John R.; Dyer, Martin J. S.; Andreotti, Amy H.
err分享
err收藏
Resolving chaperone-assisted protein folding on the ribosome at the peptide level在肽水平上解析核糖体上的伴侣蛋白辅助蛋白折叠
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-07-10
err0
errOAAI
errWales, Thomas E.; Pajak, Aleksandra; Roeselova, Alzbeta; Shivakumaraswamy, Santosh; Howell, Steven; Kjaer, Svend; Hartl, F. Ulrich; Engen, John R.; Balchin, David
err分享
err收藏
The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interactionIRS-1 PIR结构域中的丝氨酸磷酸化消除了IRS-1和IR相互作用
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-04-16
err1
PREAI
errWoo, Ju Rang; Bae, Seung-Hyun; Wales, Thomas E.; Engen, John R.; Lee, Jongsoon; Jang, Hyonchol; Park, Sangyoun
err分享
err收藏
Covalent inhibition of pro-apoptotic BAX
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-01-17
err4
PREAI
errMchenry, Matthew W.; Shi, Peiwen; Camara, Christina M.; Cohen, Daniel T.; Rettenmaier, T. Justin; Adhikary, Utsarga; Gygi, Micah A.; Yang, Ka; Gygi, Steven P.; Wales, Thomas E.; Engen, John R.; Wells, James A.; Walensky, Loren D.
err分享
err收藏
Native Capillary Electrophoresis-Mass Spectrometry of Near 1 MDa Non-Covalent GroEL/GroES/Substrate Protein Complexes近1 MDa非共价GroEL/GroES/底物蛋白质复合物的天然毛细管电泳-质谱分析
errADVANCED SCIENCE
IF14.1
err2024-01-08
err3
errOAAI
errMarie, Anne-Lise; Georgescauld, Florian; Johnson, Kendall R.; Ray, Somak; Engen, John R.; Ivanov, Alexander R.
err分享
err收藏
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory statesBTK PHTH结构域的构象异质性驱动多个调控状态
errELIFE
IF0
err2024-01-08
err3
errOAAI
errLin, David Yin-wei; Kueffer, Lauren E.; Juneja, Puneet; Wales, Thomas E.; Engen, John R.; Andreotti, Amy H.
err分享
err收藏
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90aIrisin通过其整合素受体在涉及细胞外Hsp90a的两步过程中发挥作用
errMOLECULAR CELL
IF16.6
err2023-06-01
err19
errOAAI
errMu, A.; Wales, Thomas E.; Zhou, Haixia; Draga-Coleta, Sorin-Valeriu; Gorgulla, Christoph; Blackmore, Katherine A.; Mittenbuhler, Melanie J.; Kim, Caroline R.; Bogoslavski, Dina; Zhang, Qiuyang; Wang, Zi-Fu; Jedrychowski, Mark P.; Seo, Hyuk-Soo; Song, Kijun; Xu, Andrew Z.; Sebastian, Luke; Gygi, Steven P.; Arthanari, Haribabu; Dhe-Paganon, Sirano; Griffin, Patrick R.; Engen, John R.; Spiegelman, Bruce M.
err分享
err收藏
Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains
errAMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
IF7.4
err2023-05-22
err2
errOAAI
errKlimtchuk, Elena S.; Peterle, Daniele; Bullitt, Esther; Connors, Lawreen H.; Engen, John R.; Gursky, Olga
err分享
err收藏
Structural mechanism of a drug-binding process involving a large conformational change of the protein target涉及蛋白质靶标大构象变化的药物结合过程的结构机制
errNATURE COMMUNICATIONS
IF15.7
err2023-04-05
err39
errOAAI
errAyaz, Pelin; Lyczek, Agatha; Paung, YiTing; Mingione, Victoria R.; Iacob, Roxana E.; de Waal, Parker W.; Engen, John R.; Seeliger, Markus A.; Shan, Yibing; Shaw, David E.
err分享
err收藏
Small Molecule Allosteric Modulators of the AML-associated Src-family Kinase, Hck
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-01-01
err0
PREAI
errSelzer, Ari; Gonzalez-Areizaga, Giancarlo; Wales, Thomas; Ishima, Rieko; Engen, John; Smithgall, Thomas
err分享
err收藏
Increase the flow rate and improve hydrogen deuterium exchange mass spectrometry增加流速并改进氢氘交换质谱
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2023-01-01
err3
errOAAI
errPeterle, Daniele; DePice, David; Wales, Thomas E.; Engen, John R.
err分享
err收藏
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-09-01
err12
errOAAI
errSu, Yang; Iacob, Roxana E.; Li, Jing; Engen, John R.; Springer, Timothy A.
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
M
Matthew Meyerson
H 指数: 223 · 论文数: 1.9K
S
Steven P. Gygi
H 指数: 195 · 论文数: 1.0K
B
Bruce M. Spiegelman
H 指数: 186 · 论文数: 471
T
Timothy A. Springer
H 指数: 165 · 论文数: 734
P
Pasi A. Jänne
H 指数: 163 · 论文数: 2.3K
查看更多